Abstract: A wearable monitoring device can include an electronics module containing a printed circuit board (PCB) to which one or more sensors are coupled. The one or more sensors can include one or more contacting sensors and/or one or more non-contacting sensors. In some cases, the wearable monitoring device can include an onboard power supply (e.g., a battery) and a wireless communication antenna. The PCB can be constructed to specifically include the one or more sensors on a first side facing the skin of the user when the wearable monitoring device is being worn, allowing one or more processors, memory, and other components to be included on the opposite side facing away from the user. Certain components, such as the power supply and wireless communication antenna, can be spaced apart from the PCB and located opposite the PCB from the one or more sensors.

Abstract: A glucose monitoring system can make use of electrocardiograph (ECG) data and bioimpedance data acquired from a wearable device. The ECG data and bioimpedance data can each be processed to obtain a glucose level. These values can be processed together to obtain an adapted glucose value. In some cases, photoplethysmography data can also be used to assist in processing of the ECG data. The various types of data can be acquired from sensors on a wearable device. The wearable device can be removably coupled to a user's skin, such as via an adhesive substrate. In some cases, the wearable device can include a reusable electronics module that couples to replaceable electrodes on a replaceable adhesive substrate.

Abstract: A system for acquiring electrocardiograph (ECG) and bioimpedance (BI) data is disclosed. The system (an ECG/BI measurement system) can use as few as one or two pairs of electrodes, permitting wearable devices employing the ECG/BI measurement system to be made into smaller, more comfortable, and more inconspicuous formats, as well as decreasing potential failure points in the measurement of electrical signals conducted between the system and the user. The system can measure both ECG and BI data using at least one shared pair of electrodes. In some cases, ECG and BI data are separately extracted from a measured signal across a shared pair of electrodes, while another pair of electrodes is being driven with a supply current. In other cases, internal switching can automatically switch a pair of electrodes between ECG-measuring circuitry and BI-measuring circuitry, such as based on a clock signal or other trigger.

Abstract: A multi-sensor auscultation device is disclosed that can be applied to or worn by a user to monitor multiple physiological systems of the user. The multi-sensor auscultation device can make use of two or more acoustic sensors, such as accelerometer contact microphones (ACMs), to collect acoustic data from multiple locations on the user's body. The multi-sensor auscultation device can include electrodes for detecting cardiac electrical activity and/or assessing the user's bioimpedance. The multi-sensor auscultation device can provide useful data associated with the user's cardiovascular system, respiratory system, and/or electrical characteristics. The multi-sensor auscultation device can be in the form of a reusable electronics module couplable to a disposable patch adhesive.

Abstract: A multi-sensor smart patch is disclosed that can be worn by a user to monitor multiple physiological systems of the user. The multi-sensor smart patch can make use of two or more acoustic sensors, such as accelerometer contact microphones (ACMs), to collect acoustic data from multiple locations on the user's body. The multi-sensor smart patch can include electrodes for detecting the heart's electrical activity and/or assessing the user's bioimpedance. The multi-sensor smart patch can provide useful data associated with the user's cardiovascular system, respiratory system, and electrical characteristics. The multi-sensor smart patch can be in the form of a reusable electronics module couplable to a disposable patch adhesive.

Abstract: A glucose monitoring system can make use of electrocardiograph (ECG) data and bioimpedance data acquired from a wearable device. The ECG data and bioimpedance data can each be processed to obtain a glucose level. These values can be processed together to obtain an adapted glucose value. In some cases, photoplethysmography data can also be used to assist in processing of the ECG data. The various types of data can be acquired from sensors on a wearable device. The wearable device can be removably coupled to a user's skin, such as via an adhesive substrate. In some cases, the wearable device can include a reusable electronics module that couples to replaceable electrodes on a replaceable adhesive substrate.

Abstract: A system for acquiring electrocardiograph (ECG) and bioimpedance (BI) data is disclosed. The system (an ECG/BI measurement system) can use as few as one or two pairs of electrodes, permitting wearable devices employing the ECG/BI measurement system to be made into smaller, more comfortable, and more inconspicuous formats, as well as decreasing potential failure points in the measurement of electrical signals conducted between the system and the user. The system can measure both ECG and BI data using at least one shared pair of electrodes. In some cases, ECG and BI data are separately extracted from a measured signal across a shared pair of electrodes, while another pair of electrodes is being driven with a supply current. In other cases, internal switching can automatically switch a pair of electrodes between ECG-measuring circuitry and BI-measuring circuitry, such as based on a clock signal or other trigger.

Abstract: A system for diagnosing the possibility of disease in one of a first body part and a second substantially similar body part by impedance measurements is described. The system includes an impedance module for calculating impedances of corresponding segments of the first and second body parts from current and voltage signals. The measured impedances are corrected to account for the effect of stray impedances arising from non-body part sources.

Abstract: A system and method for measuring a voltage in a body part are described. The system includes a multiplexing unit, and N body leads for electrically connecting the multiplexing unit to the body part. The system also includes a controller switching unit for allowing a current to flow through the body part between two body leads, n1 and n2 of the N body leads, and a resultant voltage to be measured between two body leads, n3 and n4 of the N body leads, where n1?n2 and n3?n4, but where n1 n2 n3 and n4 need not otherwise be distinct.

Abstract: A system and method for diagnosing the possibility of disease in a body part is described. The system includes an electrode array containing a plurality of electrodes capable of being electrically coupled to the body part. A first measurement unit makes an electrode assessment measurement with the electrode array. An electrode assessment module determines whether the plurality of electrodes are suitably coupled to the body part based on the electrode assessment measurement. If there is suitable coupling, a second measurement unit makes a diagnosis measurement with the electrode array. An electrical property module obtains an electrical property of the body part, such as impedance, based on the diagnosis measurement. A diagnosis module diagnoses the possibility of disease based on the measured electrical property.

Abstract: A system for diagnosing the possibility of disease in one of a first body part and a second substantially similar body part by impedance measurements is described. The system includes an impedance module for calculating impedances of corresponding segments of the first and second body parts from current and voltage signals. The measured impedances are corrected to account for the effect of stray impedances arising from non-body part sources.

Abstract: A system and method for measuring a voltage in a body part are described. The system includes a multiplexing unit, and N body leads for electrically connecting the multiplexing unit to the body part. The system also includes a controller switching unit for allowing a current to flow through the body part between two body leads, n1 and n2 of the N body leads, and a resultant voltage to be measured between two body leads, n3 and n4 of the N body leads, where n1≠n2 and n3≠n4, but where n1 n2 n3 and n4 need not otherwise be distinct.

Abstract: A breast electrode array and method of analysis for detecting and diagnosing diseases. In particular, the electrode array has a body, a plurality of flexible arms extending from the body, and a plurality of outer electrodes provided by the plurality of flexible arms, and a plurality of inner electrodes provided on at least one of the flexible arms and positioned partway between the body and the outer electrodes, and the outer electrodes and the inner electrodes are arranged on the arms to obtain impedance measurements between respective electrodes. Diagnostic methods based on homologous electrical difference analysis are also provided, utilizing the different topologies created by the inner and outer electrodes when taking impedance measurements.

Abstract: An impedance module for calculating the impedance of a body part creates stimulus currents for injection into the body part and receives resulting voltages generated by the body part The impedance module includes a current generator for generating the stimulus currents, the stimulus currents including a current signal and a complementary current signal thereby forming a differential current signal. The impedance module also includes voltage processing circuitry for pre-processing the received voltages and amplifying the received voltages to generate a measured voltage signal; processing circuitry for creating a current control voltage signal for controlling parameters related to the stimulus currents, and for calculating an impedance value based on the stimulus current and the measured voltage signal, and interface circuitry for interconnecting the components of the impedance module.