Abstract: A transport and delivery system which may be used for injectable materials such as radioactive injectables. The system includes a base configured to hold a material transport device containing the injectable material, and a cover including a material delivery system and a material access device. The cover is configured to be mated over the base to result in alignment of the material access device with the material transport device to allow the material delivery system to deliver the injectable materials from within the material transport device to a patient. The cover may include a handle graspable within an adult hand to facilitate grasping/handling of the system. A priming cap may be provided to facilitate priming of the material delivery system and material access device to be substantially airless.

Abstract: This invention is a safe and effective method to treat chronic pain with the oral administration of procaine as a non-selective voltage sodium channel (VGSC) blocker. The dose of oral procaine has been estimated based upon the pharmacokinetics required to produce action potential inhibition in neurons of dorsal root ganglia. Intraneural ion trapping effects and low CSF pseudocholinesterase will increase the concentration of charged procaine within Nav 1.8 channels. The co-administration of benzodiazepines will increase the therapeutic ratio of procaine mitigating central nervous system toxicity. A dibucaine number is required prior to initiation of therapy. Side effects have hindered development of selective VGSC blockers. Modification of oral procaine administration with over 100 clinical practice years of known side effects may meet this unmet need.

Abstract: This document relates to an optical device that uses adaptive optics as part of an optical system. The adaptive optics can be used to correct light rays that correspond to a portion of an eye box based on information received from an eye-tracking unit, and can also correct for aberrations in the optics in the optical device. The adaptive optics include corrective elements that can be modified using modifying elements to correct the angle of light rays, such that rays associated with a specific pupil position and gaze direction of a user's eye can be made parallel and ensure a high quality image is viewed by the user.

Abstract: The present disclosure describes near-eye display systems including an array of projectors and a one-dimensional exit pupil expander. The array of projectors can be arranged along a first dimension and can output image light towards an input coupler within a waveguide that provides one-dimensional exit pupil expansion. In some implementations, arrays of monochromatic projectors are implemented and arranged in offset columns. The input coupler in-couples the image light from the array of projectors into a TIR path within the waveguide. Different optical elements, including diffractive and reflective optics, may be implemented as the input coupler. The image light travels within the waveguide until it interacts with an output coupler. Upon interaction with the output coupler, the image light is expanded in a second dimension transverse to the first dimension and is coupled out of the waveguide.

Abstract: A speaker can have a main body with a generally spheroidal shape, which can be supported standing on its end. The speaker can include a subwoofer that faces forward. A plurality of mid-range drivers can be distributed around the sub-woofer, facing generally forward and radially outward. A plurality of tweeters can be distributed around the sub-woofer, facing generally forward and generally outward. The outer housing portion of the speaker can be covered with a fabric material. A user interface ring 162 can be touch sensitive to receive input, and can have a plurality of lights that can be illuminated separately to convey information to the user.

Abstract: Parkinson's disease is characterized by degeneration of highly metabolic dopaminergic neurons which produce clinical signs to include tremor, rigidity, and glabellar reflex. There are few objective, inexpensive, sensitive, and specific tests for early diagnosis of Parkinson's disease. In this invention, patients who manifest early objective signs of possible Parkinson's disease are pretreated with a supplement to increase central nervous system NAD+, and then subsequently administered a sodium L-lactate infusion after which the signs of early Parkinson's disease are recorded. Remission of the early signs of Parkinson's disease is diagnostic for Parkinson's disease. A clinical trial is suggested.

Abstract: A device includes a frame configured to be supported in front of a user eye. The frame has a first side facing the user eye and a second side opposite the first side and facing an environment. A light emitting diode is supported by the frame to emit light. The light emitting diode is obscured by an opaque material from an observer in front of the user in the environment. A light deflector is supported by the frame to direct the emitted light from the light emitting diode towards the user eye.

Abstract: Examples are disclosed that relate to using an array of hot mirrors in an eye-imaging system. One example provides a head-mounted display system, comprising a frame, an eye-imaging camera supported on the frame, a switchable hot mirror array comprising a plurality of switchable hot mirrors configured to direct light reflecting from an eye toward the eye-imaging camera, and a controller configured to control switching of a reflectivity of each of the plurality of switchable hot mirrors.

Abstract: Aspects of the subject disclosure are directed towards safely projecting a diffracted light pattern, such as in an infrared laser-based projection/illumination system. Non-diffracted (zero-order) light is refracted once to diffuse (defocus) the non-diffracted light to an eye safe level. Diffracted (non-zero-order) light is aberrated twice, e.g., once as part of diffraction by a diffracting optical element encoded with a Fresnel lens (which does not aberrate the non-diffracted light), and another time to cancel out the other aberration; the two aberrations may occur in either order. Various alternatives include upstream and downstream positioning of the diffracting optical element relative to a refractive optical element, and/or refraction via positive and negative lenses.

Abstract: This invention describes the potential benefits of chronic oral administration of triethyl citrate (TEC) for the treatment of Alzheimer's disease and atherosclerosis. Evidence is presented that TEC crosses the blood brain barrier via passive diffusion, and the pharmacologic properties of TEC are distinct from administration of citrate salts. Further clinical trials in animal and human subjects is encouraged.

Abstract: An illumination system for non-emissive polarization-sensitive microdisplays such as LCoS is implemented in a waveguide that guides illumination light from an unpolarized source to the microdisplay while simultaneously recycling light of the wrong polarization for the microdisplay to improve illumination efficiency. Polarization recycling may be performed at one or more of an input coupler that in-couples illumination light to the waveguide, the waveguide itself, or an output coupler that out-couples the illumination light from the waveguide to the microdisplay.

Abstract: Examples are disclosed that relate to using an array of hot mirrors in an eye-imaging system. One example provides a head-mounted display system, comprising a frame, an eye-imaging camera supported on the frame, a switchable hot mirror array comprising a plurality of switchable hot mirrors configured to direct light reflecting from an eye toward the eye-imaging camera, and a controller configured to control switching of a reflectivity of each of the plurality of switchable hot mirrors.