Patents by Inventor Joelle E. Gabay

Joelle E. Gabay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antimicrobial proteins, compositions containing same and uses thereof
    Patent number: 5654167
    Abstract: The present invention provides purified polypeptides useful as antimicrobial agents. These polypeptides comprise human polymorphonuclear leukocyte polypeptides having molecular weights of about 25,000 daltons, 29,000 daltons and 54,000 daltons. These polypeptides have respiratory burst-independent, antibacterial activity at a pH from about 5.0 to about 8.0, at calcium ion concentrations up to about 10 mM, and at sodium chloride concentrations up to about 0.3M.
    Type: Grant
    Filed: March 8, 1994
    Date of Patent: August 5, 1997
    Assignees: Cornell Research Foundation, Inc., Rockefeller University
    Inventors: Joelle E. Gabay, Carl F. Nathan
  • Antimicrobial proteins, compositions containing same and uses thereof
    Patent number: 5338724
    Abstract: The present invention provides a composition of matter useful as an antimicrobial agent. This composition of matter comprises at least two polypeptides selected from the group consisting of human polymorphonuclear leukocyte, polypeptides having on apparent molecular weights of about 3,500 daltons, about 13,000 daltons, about 18,000 daltons, about 29,000 daltons, and about 54,000 daltons. The composition of matter has respiratory burst-independent, antimicrobial activity for bacteria and fungi at a pH from about 5.0 to about 8.0 and at calcium ion concentrations up to about 10 mM, bactericidal activity at sodium chloride concentrations up to about 0.3M, and fungicidal activity at sodium chloride concentrations up to about 0.15M. Methods for preparing this composition of matter are also provided.Further provided are purified polypeptides useful as antimicrobial agents, and methods for producing these polypeptides.
    Type: Grant
    Filed: February 11, 1992
    Date of Patent: August 16, 1994
    Assignees: Cornell Research Foundation, Inc., Rockefeller University
    Inventors: Joelle E. Gabay, Carl E. Nathan
  • Antimicrobial proteins, compositions containing same and uses thereof
    Patent number: 5126257
    Abstract: The present invention provides a composition of matter useful as an antimicrobial agent. This composition of matter comprises an extract derived from human polymorphonuclear leukocytes, said extract including a polypeptide having an apparent molecular weight of about 13,000 daltons, a polypeptide having an apparent molecular weight of about 29,000 daltons and a polypeptide having an apparent molecular weight of about 54,000 daltons. The extract also has oxygen-independent, antimicrobial activity for bacteria and fungi at a pH from about 5.0 to about 8.0 and at calcium ion concentrations up to about 10 mM, bactericidal activity at sodium chloride concentrations up to about 0.3M, and fungicidal activity at sodium chloride concentrations up to about 0.15M. Methods for preparing this composition of matter are also provided. Further provided are purified polypeptides useful as antimicrobial agents, and methods for producing these polypeptides.
    Type: Grant
    Filed: October 6, 1987
    Date of Patent: June 30, 1992
    Assignees: Cornell Research Foundation, Rockefeller University
    Inventors: Joelle E. Gabay, Carl F. Nathan
  • Antimicrobial proteins, compositions containing same and uses thereof
    Patent number: 5087569
    Abstract: The present invention provides a composition of matter useful as an antimicrobial agent. This composition of matter comprises at least two polypeptides selected from the group consisting of human polymorphonuclear leukocyte, polypeptides having on apparent molecular weights of about 3,500 daltons, about 13,000 daltons, about 18,000 daltons, about 29,000 daltons, and about 54,000 daltons. The composition of matter has respiratory burst-independent, antimicrobial activity for bacteria and fungi at a pH from about 5.0 to about 8.0 and at calcium ion concentrations up to about 10 mM, bactericidal activity at sodium chloride concentrations up to about 0.3M, and fungicidal activity at sodium chloride concentrations up to about 0.15M. Methods for preparing this composition of matter are also provided. Further provided are purified polypeptides useful as antimicrobial agents, and methods for producing these polypeptides.
    Type: Grant
    Filed: November 25, 1987
    Date of Patent: February 11, 1992
    Assignee: Cornell Research Foundation, Inc. and The Rockefeller University
    Inventors: Joelle E. Gabay, Carl F. Nathan