Patents by Inventor Joelle Thonnard

Joelle Thonnard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds from
    Patent number: 7122197
    Abstract: The invention provides BASB020 polypeptides and polynucleotides encoding BASB020 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Grant
    Filed: May 7, 1999
    Date of Patent: October 17, 2006
    Assignee: SmithKline Beecham Biologicals S.A.
    Inventor: Joelle Thonnard
  • Vaccine composition
    Publication number: 20060216307
    Abstract: The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
    Type: Application
    Filed: June 9, 2006
    Publication date: September 28, 2006
    Inventors: Francois-Xavier Berthet, Wilfried Dalemans, Philippe Denoel, Guy Dequesne, Christiane Feron, Yves Lobet, Jan Poolman, Georges Thiry, Joelle Thonnard, Pierre Voet
  • Vaccine composition
    Publication number: 20060204520
    Abstract: The present invention relates to the field of novel, engineered Gram-negative bacterial strains that have improved outer-membrane vesicle shedding properties, and vaccine compositions comprising these bacteria or vesicles. The present invention provides a hyperblebbing Gram-negative bacterium which has been genetically modified by either or both processes selected from a group consisting of: down-regulation of expression of one or more tol genes; and mutation of one or more gene(s) encoding a protein comprising a peptidoglycan-associated site to attenuate the peptidoglycan-binding activity of the protein(s).
    Type: Application
    Filed: May 15, 2006
    Publication date: September 14, 2006
    Inventors: Francois-Xavier Berthet, Philippe Denoel, Cecile Neyt, Jan Poolman, Joelle Thonnard
  • Compounds from moraxella catarrhalis
    Publication number: 20060147462
    Abstract: This invention provides BASB020 polypeptides and polynucleotides encoding BASB020 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Application
    Filed: February 28, 2006
    Publication date: July 6, 2006
    Applicant: SmithKline Beecham Biologicals S.A.
    Inventor: Joelle Thonnard
  • Novel compounds
    Publication number: 20050118659
    Abstract: The invention provides BASB231 polypeptides and polynucleotides encoding BASB231 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Application
    Filed: December 30, 2002
    Publication date: June 2, 2005
    Inventors: Cindy Castado, Joelle Thonnard
  • Moraxella catarrhalis antigen, corresponding gene and uses thereof
    Publication number: 20040265278
    Abstract: The invention provides BASB109 polypeptides and polynucleotides encoding BASB109 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Application
    Filed: July 22, 2004
    Publication date: December 30, 2004
    Applicant: SmithKline Beecham
    Inventor: Joelle Thonnard
  • Novel compounds
    Publication number: 20040241638
    Abstract: The invention provides BASB226 and BASB227 polypeptides and polynucleotides encoding BASB226 and BASB227 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Application
    Filed: June 18, 2004
    Publication date: December 2, 2004
    Inventor: Joelle Thonnard
  • Novel compounds
    Publication number: 20040241687
    Abstract: The invention provides BASB230 polypeptides and polynucleotides encoding BASB230 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Application
    Filed: June 18, 2004
    Publication date: December 2, 2004
    Inventors: Joelle Thonnard, Cindy Castado
  • Moraxella catarrhalis antigen, corresponding gene and uses thereof
    Patent number: 6805868
    Abstract: The invention provides BASB109 polypeptides and polynucleotides encoding BASB109 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: October 19, 2004
    Assignee: GlaxoSmithKline Biologicals S.A.
    Inventor: Joelle Thonnard
  • Novel compounds
    Publication number: 20040171805
    Abstract: The invention provides BASB223 and BASB224 polypeptides and polynucleotides encoding BASB223 and BASB224 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Application
    Filed: April 2, 2004
    Publication date: September 2, 2004
    Inventor: Joelle Thonnard
  • BASB006 polypeptides from neisseria meningitidis and immunogenic compositions thereof
    Publication number: 20040137530
    Abstract: The invention provides BASB006 polypeptides and polynucleotides encoding BASB006 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Application
    Filed: December 19, 2003
    Publication date: July 15, 2004
    Applicant: Smithkline Beecham Biologicals S.A.
    Inventor: Joelle Thonnard
  • Vaccine composition
    Publication number: 20040126389
    Abstract: The present invention relates to the field of vaccine formulation, particularly the field of novel adjuvant compositions comprising outer membrane vesicles (or blebs), and advantageous methods of detoxifying these compositions, and advantageous methods of use of such adjuvants.
    Type: Application
    Filed: September 15, 2003
    Publication date: July 1, 2004
    Inventors: Francois-Xavier Jacques Berthet, Wilfried L J Dalemans, Philippe Denoel, Guy Dequesne, Chriatiane Feron, Nathalie Garcon, Yves Lobet, Jan Poolman, Georges Thiry, Joelle Thonnard, Pierre Voet
  • Vaccine composition
    Publication number: 20040116665
    Abstract: The present invention relates to the field of novel, engineered Gram-negative bacterial strains that have improved outer-membrane vesicle shedding properties, and vaccine compositions comprising these bacteria or vesicles. The present invention provides a hyperbledding Gram-negative bacterium which has been genetically modified by either or both processes selected from a group of consisting of: down-regulation of expression of one or more tol genes; and mutation of one or more gene(s) encoding a protein comprising a peptidoglycan-associated site to attenuate the peptidoglycan-binding activity of the protein(s).
    Type: Application
    Filed: December 17, 2003
    Publication date: June 17, 2004
    Inventors: Francois-Xavier Jacques Berthet, Philippe Denoel, Cecile Anne Neyt, Jan Poolman, Joelle Thonnard
  • Novel compounds
    Publication number: 20040067238
    Abstract: The invention provides BASB206 polypeptides and polynucleotides encoding BASB206 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Application
    Filed: October 23, 2003
    Publication date: April 8, 2004
    Inventor: Joelle Thonnard
  • Novel compounds
    Publication number: 20040058863
    Abstract: The invention provides BASB203 polypeptides and polynucleotides encoding BASB203 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Application
    Filed: October 1, 2003
    Publication date: March 25, 2004
    Inventor: Joelle Thonnard
  • Novel compounds
    Publication number: 20040059090
    Abstract: The present invention provides the sequencing of the entire genome of Haemophilus influenzae Rd. SEQ ID NO: 1. The present invention further provides the sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use. In addition to the entire genomic sequence, the present invention identifies over 1700 protein encoding fragments of the genome and identifies, by position relative to a unique Not I restriction endonuclease site, any regulatory elements which modulate the expression of the protein encoding fragments of the Haemophilus genome.
    Type: Application
    Filed: October 24, 2003
    Publication date: March 25, 2004
    Inventor: Joelle Thonnard
  • Cloning of BASB023 antigen from Moraxella catarrhalis
    Patent number: 6706271
    Abstract: The invention provides BASB023 polypeptides encoding BASB023 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Grant
    Filed: May 14, 2001
    Date of Patent: March 16, 2004
    Assignee: SmithKline Beecham Biologicals s.a.
    Inventor: Joelle Thonnard
  • Novel compounds
    Publication number: 20040047875
    Abstract: The invention provides BASB201 polypeptides and polynucleotides encoding BASB201 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Application
    Filed: August 28, 2003
    Publication date: March 11, 2004
    Inventor: Joelle Thonnard
  • Novel compounds
    Publication number: 20040043456
    Abstract: The invention provides BASB209 polypeptides and polynucleotides encoding BASB209 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Application
    Filed: September 22, 2003
    Publication date: March 4, 2004
    Inventor: Joelle Thonnard
  • BASB006 polypeptides from Neisseria meningitidis and immunogenic compositions thereof
    Patent number: 6696062
    Abstract: Provided are BASB006 polypeptides from Neisseria meningitidis. Also provided are fusion proteins containing BASB006 polypeptides. The invention also relates to immunogenic compositions containing BASB006 polypeptides.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: February 24, 2004
    Assignee: SmithKline Beecham Biologicals s.a.
    Inventor: Joelle Thonnard