Patents by Inventor Joen Luirink

Joen Luirink has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DECORATED INCLUSION BODY AND USES THEREOF
    Publication number: 20220064691
    Abstract: The present disclosure relates in general to the field of inclusion bodies. Provided are inclusion bodies comprising a coupling peptide suitable for coupling to a partner peptide through the formation of a covalent isopeptide bond, as well as the use of different ligation systems for enabling efficient and stable decoration of inclusion bodies with, for example, biologically functional molecules to improve the use of inclusion bodies in biotechnology and biomedicine.
    Type: Application
    Filed: February 14, 2020
    Publication date: March 3, 2022
    Inventors: Joen LUIRINK, Wouter Simon Petrus Jong, Hendrik Bart VAN DEN BERG VAN SAPAROEA
  • Fusion polypeptides comprising one or more inclusion body tags, methods and uses
    Patent number: 11124555
    Abstract: A fusion polypeptide, comprising an inclusion body tag fused to at least one polypeptide of interest, is provided. The inclusion body tag comprises an inclusion body forming (IBF) amino acid sequence selected from X14X15AX17X18X19GLTVA GMLG and sequences having at least 71% identity thereto. Also provided are inclusion bodies comprising the fusion polypeptide, as well as nucleic acids, expression vectors, host cells and methods for its production.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: September 21, 2021
    Assignee: ABERA BIOSCIENCE AB
    Inventors: Wouter Simon Petrus Jong, Joen Luirink
  • Display of heterologous molecules on bacterial cells and membrane vesicles
    Patent number: 11059868
    Abstract: The present invention concerns Gram-negative bacterial cells or Outer Membrane Vesicles (OMVs) which display on their outer surface an autotransporter (AT) fusion protein covalently coupled via an isopeptide bond to a heterologous molecule. These bacterial cells and OMVs are suitable for use in vaccines or targeted drug delivery of antigens or therapeutic agents to specific cells or tissues.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: July 13, 2021
    Inventors: Hendrik Bart Van Den Berg Van Saparoea, Wouter Simon Petrus Jong, Joen Luirink
  • DISPLAY OF HETEROLOGOUS MOLECULES ON BACTERIAL CELLS AND MEMBRANE VESICLES
    Publication number: 20200377556
    Abstract: The present invention concerns Gram-negative bacterial cells or Outer Membrane Vesicles (OMVs) which display on their outer surface an autotransporter (AT) fusion protein covalently coupled via an isopeptide bond to a heterologous molecule. These bacterial cells and OMVs are suitable for use in vaccines or targeted drug delivery of antigens or therapeutic agents to specific cells or tissues.
    Type: Application
    Filed: October 25, 2018
    Publication date: December 3, 2020
    Applicant: ABERA BIOSCIENCE AB
    Inventors: Hendrik Bart Van Den Berg Van Saparoea, Wouter Simon Petrus Jong, Joen Luirink
  • NEW COMPOSITIONS, METHODS AND USES
    Publication number: 20190359671
    Abstract: A fusion polypeptide, comprising an inclusion body tag fused to at least one polypeptide of interest, is provided. The inclusion body tag comprises an inclusion body forming (IBF) amino acid sequence selected from X14X15AX17X18X19GLTVA GMLG and sequences having at least 71% identity thereto. Also provided are inclusion bodies comprising the fusion polypeptide, as well as nucleic acids, expression vectors, host cells and methods for its production.
    Type: Application
    Filed: January 29, 2018
    Publication date: November 28, 2019
    Inventors: Wouter Simon Petrus JONG, Joen LUIRINK
  • FUSION PROTEIN COMPRISING STREPTOCOCCAL ANTIGEN
    Publication number: 20170258885
    Abstract: The disclosure provides a fusion protein comprising at least one antigenic fragment of a protein from a bacterium from genus Streptococcus, as well as means for its expression. Outer membrane vesicles and vaccines comprising the fusion protein are also disclosed, as well as a method of vaccination using such vaccines.
    Type: Application
    Filed: March 13, 2017
    Publication date: September 14, 2017
    Inventors: Joen LUIRINK, Wouter Simon Petrus JONG, Marinus Isaäk DE JONGE, Kirsten KUIPERS
  • Fusion protein for secretory protein expression
    Patent number: 9322011
    Abstract: There is provided a fusion protein suitable for secretion of more than one polypeptide(s) of interest (POI) comprising a signal peptide, a POI, a passenger domain comprising a beta stem domain from an autotransporter protein, and a translocator domain from an autotransporter protein, wherein the beta stem-forming sequence of the passenger domain is essentially intact and the POI(s) is/are fused to the beta stem domain.
    Type: Grant
    Filed: September 28, 2011
    Date of Patent: April 26, 2016
    Assignee: ABERA BIOSCIENCE AB
    Inventors: Joen Luirink, Wouter S. P. Jong
  • FUSION PROTEIN FOR SECRETORY PROTEIN EXPRESSION
    Publication number: 20130344099
    Abstract: There is provided a fusion protein suitable for secretion of more than one polypeptide(s) of interest (POI) comprising a signal peptide, a POI, a passenger domain comprising a beta stem domain from an autotransporter protein, and a translocator domain from an autotransporter protein, wherein the beta stem-forming sequence of the passenger domain is essentially intact and the POI(s) is/are fused to the beta stem domain.
    Type: Application
    Filed: September 28, 2011
    Publication date: December 26, 2013
    Applicant: ABERA BIOSCIENCE AB
    Inventors: Joen Luirink, Wouter S. P. Jong