Patents by Inventor Joerg Rieke-Zapp

Joerg Rieke-Zapp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9434696
    Abstract: The disclosure relates to a process for the preparation of the enantiomeric forms of 2,3-diaminopropionic acid derivatives of formula I, wherein R1, R2 and R3 are defined as in the disclosure, by racemate resolution. The separation of the racemate into its enantiomers takes place through formation of diastereomeric salts upon addition of an enantiomerically pure auxiliary, and subsequent separation by fractional crystallization.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: September 6, 2016
    Assignee: Sanofi
    Inventors: Claus-Dieter Graf, Joerg Rieke-Zapp
  • Publication number: 20150018554
    Abstract: The disclosure relates to a process for the preparation of the enantiomeric forms of 2,3-diaminopropionic acid derivatives of formula I, wherein R1, R2 and R3 are defined as in the disclosure, by racemate resolution. The separation of the racemate into its enantiomers takes place through formation of diastereomeric salts upon addition of an enantiomerically pure auxiliary, and subsequent separation by fractional crystallization.
    Type: Application
    Filed: September 30, 2014
    Publication date: January 15, 2015
    Inventors: Claus-Dieter GRAF, Joerg RIEKE-ZAPP
  • Patent number: 8877926
    Abstract: The disclosure relates to a process for the preparation of the enantiomeric forms of 2,3-diaminopropionic acid derivatives of formula I, wherein R1, R2 and R3 are defined as in the disclosure, by racemate resolution. The separation of the racemate into its enantiomers takes place through formation of diastereomeric salts upon addition of an enantiomerically pure auxiliary, and subsequent separation by fractional crystallization.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: November 4, 2014
    Assignee: Sanofi
    Inventors: Claus-Dieter Graf, Joerg Rieke-Zapp
  • Publication number: 20130172248
    Abstract: The invention relates to 3-[4-(phenylaminooxalylamino)phenyl]hex-4-ynoic acids, and to physiologically compatible salts thereof. The invention relates to compounds of the formula I in which R1, R2, R3 and R4 are each defined as specified, and to physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
    Type: Application
    Filed: January 4, 2013
    Publication date: July 4, 2013
    Inventors: Elisabeth DEFOSSA, Viktoria DIETRICH, Thomas KLABUNDE, Stefanie KEIL, Siegfried STENGELIN, Guido HASCHKE, Andreas HERLING, Johanna KUHLMANN-GOTTKE, Stefan BARTOSCHEK, Simon GESSLER, Angela DUDDA, Guenter BILLEN, Thomas OLPP, Joerg RIEKE-ZAPP
  • Patent number: 8283374
    Abstract: The present invention relates to processes for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl)acetylguanidine derivatives of the formula I via 3-hydroxy-2,3-dihydro-1H-isoindol-1-one derivatives or 3-(2-carbamoylphenyl)-acrylic ester derivatives as intermediates, to a process for optical resolution, and to intermediates of the process according to the invention.
    Type: Grant
    Filed: April 2, 2009
    Date of Patent: October 9, 2012
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Gerrit Schubert, Joerg Rieke-Zapp, Johannes Keil, Heinz-Werner Kleemann, Reda Hanna, Bao-Guo Huang, Xiao-Dong Wu, Yves Gouraud
  • Patent number: 8053590
    Abstract: The invention relates to a method for producing enantiomers form of 2,3-diaminopropionic acid derivatives of formula (I) by asymmetric hydrogenation from compounds of formula (II).
    Type: Grant
    Filed: April 6, 2009
    Date of Patent: November 8, 2011
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Joerg Rieke-Zapp, Guenter Billen
  • Publication number: 20100087414
    Abstract: The invention relates to a novel method for the synthesis of N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5 -difluorophenyl)methylsulfonamide.
    Type: Application
    Filed: December 11, 2009
    Publication date: April 8, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Philippe BOFFELLI, Michel DELTHIL, Luc GRONDARD, Maxime LAMPILAS, Joel MALPART, Stephane MUTTI, Lahlou NAIT-BOUDA, Joerg RIEKE-ZAPP
  • Patent number: 7687493
    Abstract: The present invention relates to a novel method for the preparation of azetidine derivatives such as N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-quinol-6-ylmethylsulfonamide and the dihydrochloride thereof and N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulfonamide.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: March 30, 2010
    Assignee: Aventis Pharma SA
    Inventors: Stephane Mutti, Michel Lavigne, Luc Grondard, Joel Malpart, Joerg Rieke-Zapp, Veronique Crocq-Stuerga
  • Publication number: 20090203918
    Abstract: The invention relates to a method for producing enantiomers form of 2,3-diaminopropionic acid derivatives of formula (I) by asymmetric hydrogenation from compounds of formula (II).
    Type: Application
    Filed: April 6, 2009
    Publication date: August 13, 2009
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Joerg RIEKE-ZAPP, Guenter BILLEN
  • Publication number: 20090203761
    Abstract: The present invention relates to processes for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl)acetylguanidine derivatives of the formula I via 3-hydroxy-2,3-dihydro-1H-isoindol-1-one derivatives or 3-(2-carbamoylphenyl)-acrylic ester derivatives as intermediates, to a process for optical resolution, and to intermediates of the process according to the invention.
    Type: Application
    Filed: April 2, 2009
    Publication date: August 13, 2009
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Gerrit SCHUBERT, Joerg RIEKE-ZAPP, Johannes KEIL, Heinz-Werner KLEEMANN, Reda HANNA, Bao-Guo HUANG, Xiao-Dong WU, Yves GOURAUD
  • Patent number: 7531569
    Abstract: A method and apparatus for preventing board warpage during the application and curing or drying of liquid epoxies, or the like, on printed circuit boards using a clamping fixture assembly, which includes at least one clamping fixture support and at least one clamping fixture overlay. If desired, a plurality of printed circuit boards may be processed using an appropriate clamping fixture assembly. Furthermore, the clamping fixture may be constructed so a slight bow or curvature thereof can counter either a convex or concave bow or curvature of the printed circuit board. In the method, at least one printed circuit board is mounted to a clamping fixture support whereby a clamping fixture overlay is placed on top of the first printed circuit board.
    Type: Grant
    Filed: December 1, 2004
    Date of Patent: May 12, 2009
    Assignee: sanofi-aventis Deutschland GmbH
    Inventors: Gerrit Schubert, Joerg Rieke-Zapp, Johannes Keil, Heinz-Werner Kleemann, Reda Hanna, Bao-Guo Huang, Xiao-Dong Wu, Yves Gouraud
  • Patent number: 7514578
    Abstract: The invention relates to a method for producing enantiomeris form of 2, 3-diaminopropionic acid derivatives of formula (I) by asymetric hydrogenation from compounds of formula (II).
    Type: Grant
    Filed: January 10, 2007
    Date of Patent: April 7, 2009
    Assignee: sanofi-aventis Deutschland GmbH
    Inventors: Joerg Rieke-Zapp, Guenter Billen
  • Publication number: 20080312205
    Abstract: The invention relates to a novel method for the synthesis of N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulfonamide.
    Type: Application
    Filed: August 20, 2008
    Publication date: December 18, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Philippe BOFFELLI, Michel DELTHIL, Luc GRONDARD, Maxime LAMPILAS, Joel MALPART, Stephane MUTTI, Lahlou NAIT-BOUDA, Joerg RIEKE-ZAPP
  • Patent number: 7429668
    Abstract: The invention relates to a novel method for the synthesis of N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulfonamide.
    Type: Grant
    Filed: March 28, 2007
    Date of Patent: September 30, 2008
    Assignee: Sanofi-Aventis
    Inventors: Philippe Boffelli, Michel Delthil, Luc Grondard, Maxime Lampilas, Joel Malpart, Stephane Mutti, Lahlou Nait-Bouda, Joerg Rieke-Zapp
  • Publication number: 20070270463
    Abstract: The present invention relates to a novel method for the preparation of azetidine derivatives such as N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-quinol-6-ylmethylsulfonamide and the dihydrochloride thereof and N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulfonamide.
    Type: Application
    Filed: March 22, 2007
    Publication date: November 22, 2007
    Applicant: SANOFI-AVENTIS
    Inventors: Stephane Mutti, Michel Lavigne, Luc Grondard, Joel Malpart, Joerg Rieke-Zapp, Veronique Crocq-Stuerga
  • Publication number: 20070244084
    Abstract: The invention relates to a novel method for the synthesis of N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulfonamide.
    Type: Application
    Filed: March 28, 2007
    Publication date: October 18, 2007
    Applicant: AVENTIS PHARMA SA
    Inventors: Philippe Boffelli, Michel Delthil, Luc Grondard, Maxime Lampilas, Joel Malpart, Stephane Mutti, Lahlou Nait-Bouda, Joerg Rieke-Zapp
  • Publication number: 20070238778
    Abstract: The invention relates to a method for producing enantiomeris form of 2,3-diaminopropionic acid derivatives of formula (I) by asymetric hydrogenation from compounds of formula (II).
    Type: Application
    Filed: January 10, 2007
    Publication date: October 11, 2007
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Joerg Rieke-Zapp, Guenter Billen
  • Patent number: 7223796
    Abstract: The invention relates to acyl-4-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives. The invention particularly relates to compounds of formula I, in which the radicals have the given meanings described herein, and to their physiologically tolerated salts and processes for preparing them. The compounds are, for example, suitable for use as antidiabetics.
    Type: Grant
    Filed: April 10, 2003
    Date of Patent: May 29, 2007
    Assignee: Sanofi-aventis Deutschland GmbH
    Inventors: Elisabeth Defossa, Dieter Kadereit, Karl Schoenafinger, Thomas Klabunde, Hans-Joerg Burger, Andreas Herling, Karl-Ulrich Wendt, Erich Von Roedern, Alfons Enhsen, Joerg Rieke-Zapp
  • Publication number: 20050124681
    Abstract: A method and apparatus for preventing board warpage during the application and curing or drying of liquid epoxies, or the like, on printed circuit boards using a clamping fixture assembly, which includes at least one clamping fixture support and at least one clamping fixture overlay. If desired, a plurality of printed circuit boards may be processed using an appropriate clamping fixture assembly. Furthermore, the clamping fixture may be constructed so a slight bow or curvature thereof can counter either a convex or concave bow or curvature of the printed circuit board. In the method, at least one printed circuit board is mounted to a clamping fixture support whereby a clamping fixture overlay is placed on top of the first printed circuit board.
    Type: Application
    Filed: December 1, 2004
    Publication date: June 9, 2005
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Gerrit Schubert, Joerg Rieke-Zapp, Johannes Keil, Heinz-Werner Kleemann, Reda Hanna, Bao-Guo Huang, Xiao-Dong Wu, Yves Gouraud
  • Publication number: 20040077716
    Abstract: The invention relates to acyl-4-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives.
    Type: Application
    Filed: April 10, 2003
    Publication date: April 22, 2004
    Inventors: Elisabeth Defossa, Dieter Kadereit, Karl Schoenafinger, Thomas Klabunde, Hans-Joerg Burger, Andreas Herling, Karl-Ulrich Wendt, Erich Von Roedern, Alfons Enhsen, Joerg Rieke-Zapp