Patents by Inventor Joern VOIGT
Joern VOIGT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240118209Abstract: A method is proposed for detecting at least one fluorescence pattern on an immunofluorescence image of a biological cell substrate, comprising the following steps: incubating the cell substrate with a liquid patient sample, which potentially includes primary antibodies, and furthermore with secondary antibodies, which are marked using a fluorescence stain, irradiating the cell substrate using excitation radiation and capturing the immunofluorescence image, determining segmentation information comprising at least one first and one second segmentation area, wherein the segmentation areas each represent a respective cell substrate area, via segmentation of the immunofluorescence image using a first neural network, determining a boundary area, which represents a transition from the first cell substrate area towards the second cell substrate area in the fluorescence image, on the basis of the segmentation information, selecting multiple partial images from the immunofluorescence image along the boundary area, deteType: ApplicationFiled: September 29, 2023Publication date: April 11, 2024Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Jens Hocke, Jens Krauth, Stefan Gerlach, Christopher Krause, Melanie Hahn, Jörn Voigt, Enno SCHMIDT, Nina VAN BEEK
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Publication number: 20240119589Abstract: A method is proposed for detecting a presence of a fluorescence pattern on an immunofluorescence image of a biological cell substrate, comprising the following steps: incubating the cell substrate with a liquid patient sample, which potentially comprises primary antibodies, and furthermore with secondary antibodies, which are marked using a fluorescence stain, irradiating the cell substrate using excitation radiation and capturing the immunofluorescence image, determining respective items of location information, which indicate respective locations of respective relevant subsections of the cell substrate in the fluorescence image, and determining respective first partial confidence measures of respective presences of the fluorescence pattern on the respective subsections by means of a first neural network on the basis of the overall fluorescence image, extracting respective image subsections, which correspond to the respective subsections of the cell substrate, from the fluorescence image on the basis of theType: ApplicationFiled: September 22, 2023Publication date: April 11, 2024Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Jens KRAUTH, Jens HOCKE, Stefan GERLACH, Christopher KRAUSE, Melanie HAHN, Jörn VOIGT
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Patent number: 11854191Abstract: An image processing method is provided for displaying cells from a plurality of pathology images or overall images. A respective overall image represents a respective patient tissue sample or a respective patient cell sample.Type: GrantFiled: March 2, 2021Date of Patent: December 26, 2023Assignee: EUROIMMUN Medizinische Labordiagnostika AGInventors: Christian Marzahl, Stefan Gerlach, Joern Voigt, Christine Kroeger
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Publication number: 20230071078Abstract: There is proposed a method for detecting a presence of a fluorescence pattern type on an organ segment via immunofluorescence microscopy and digital image processing. The steps comprise: provision of the organ segment, incubation of the organ segment with a liquid patient sample, incubation of the organ segment with secondary antibodies which have been labelled with a fluorescent dye, acquisition of a fluorescence image of the organ segment in a colour channel corresponding to the fluorescent dye, and provision of the fluorescence image to a neural network. What takes place by means of the neural network is simultaneous determination of segmentation information through segmentation of the fluorescence image and, furthermore, of a measure of confidence indicating an actual presence of the fluorescence pattern type.Type: ApplicationFiled: August 25, 2022Publication date: March 9, 2023Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Stefan GERLACH, Jens KRAUTH, Christian MARZAHL, Christopher KRAUSE, Jens HOCKE, Maick DANCKWARDT, Melanie HAHN, Jörn VOIGT
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Patent number: 11549889Abstract: A method and a device are useful for detecting a binding of autoantibodies from a patient sample to double-stranded deoxyribonucleic acid (DNA) using Crithidia luciliae cells by fluorescence microscopy and by digital image processing.Type: GrantFiled: March 17, 2020Date of Patent: January 10, 2023Assignee: EUROIMMUN Medizinische Labordiagnostika AGInventors: Stefan Gerlach, Christian Marzahl, Maick Danckwardt, Joern Voigt
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Publication number: 20220404283Abstract: A method for detecting at least one potential presence of at least one fluorescence pattern type on an organ section by means of immunofluorescence microscopy and by means of digital image processing is disclosed. An organ section is provided on a slide and the section is incubated with a liquid patient sample which potentially includes primary antibodies and with secondary antibodies which have been labelled with a fluorescent dye. A fluorescence image of the organ section is acquired. A determination is made, by segmentation of the fluorescence image by means of a first neural network, of a sub-area of the fluorescence image that is relevant to formation of the fluorescence pattern type. A determination is made, on the basis of the fluorescence image by means of a second neural network, of the measure of confidence that indicates an actual presence of the fluorescence pattern type.Type: ApplicationFiled: December 21, 2021Publication date: December 22, 2022Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Jens Krauth, Stefan Gerlach, Christian Marzahl, Christopher Krause, Jens Hocke, Melanie Hahn, Joern Voigt
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Publication number: 20220228989Abstract: A method and apparatus are provided for detecting respective potential presences of respective different cellular fluorescence pattern types on a biological cellular substrate including human epithelioma cells (HEp cells), wherein the fluorescence pattern types include different antinuclear antibody fluorescence pattern types. A method is also provided for detecting potential presences of different cellular fluorescence pattern types on a biological cellular substrate including human epithelioma cells by means of digital image processing, as well as a computing unit, a data network device, a computer program product and a data carrier signal therefor.Type: ApplicationFiled: January 19, 2022Publication date: July 21, 2022Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Christopher Krause, Jens Krauth, Stefan Gerlach, Christian Marzahl, Melanie Hahn, Joern Voigt
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Publication number: 20220196553Abstract: A method for detecting at least one potential presence of at least one fluorescence pattern type on an organ section by means of immunofluorescence microscopy and by means of digital image processing is disclosed. An organ section is provided on a slide and the section is incubated with a liquid patient sample which potentially includes primary antibodies and with secondary antibodies which have been labelled with a fluorescent dye. A fluorescence image of the organ section is acquired. A determination is made, by segmentation of the fluorescence image by means of a first neural network, of a sub-area of the fluorescence image that is relevant to formation of the fluorescence pattern type. A determination is made, on the basis of the fluorescence image by means of a second neural network, of the measure of confidence that indicates an actual presence of the fluorescence pattern type.Type: ApplicationFiled: December 21, 2021Publication date: June 23, 2022Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Jens Krauth, Stefan Gerlach, Christian Marzahl, Christopher Krause, Jens Hocke, Melanie Hahn, Joern Voigt
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Patent number: 11367187Abstract: A method is for detecting respective potential presence of respective different antinuclear antibody fluorescence pattern types on a biological cell substrate including human epithelioma cells, including: acquiring a first image which represents staining of the cell substrate by a first fluorescent dye, and acquiring a second image which represents staining of the cell substrate by a second fluorescent dye, detecting, on the basis of the first image, respective image segments which in each case represent at least one mitotic cell, selecting, on the basis of the detected image segments, subimages of the first image and subimages corresponding thereto of the second image and detecting, on the basis of the selected subimages of the first image and of the selected subimages of the second image, respective actual presence of respective cellular fluorescence pattern types by means of a convolutional neural network.Type: GrantFiled: July 2, 2020Date of Patent: June 21, 2022Assignee: EUROIMMUN Medizinische Labordiagnostika AGInventors: Jens Krauth, Christopher Krause, Joern Voigt, Melanie Hahn, Christian Marzahl, Stefan Gerlach
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Patent number: 11305289Abstract: A method is useful for automated detection of antibodies in a liquid biological sample with an antigen chip having antigen spots which are applied thereon and which have an identical, common dye. The antigen spots form respective antigen spot sets which form corresponding respective, regular antigen spot patterns. Furthermore, reference spots comprising the identical dye are applied, and form a reference spot set which forms a regular reference pattern. The reference pattern differs with respect to its regularity from the antigen spot patterns. Through a first image information item which represents a color of the reference spots and of the antigen spots due to the identical, first dye and through a second image information item which represents a potential color of the antigen spots due to a second dye after an incubation, binding of antibodies of the biological sample to respective antigen types is then determined by image processing.Type: GrantFiled: June 17, 2019Date of Patent: April 19, 2022Assignee: EUROIMMUN Medizinische Labordiagnostika AGInventors: Katja Morgenroth, Vanessa Viertel, Ulf Steller, Stefan Gerlach, Christian Marzahl, Jörn Voigt, Winfried Stöcker
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Publication number: 20220082567Abstract: There is proposed a method for detecting a binding of autoantibodies from a patient sample to double-stranded deoxyribonucleic acid using Crithidia luciliae cells by means of fluorescence microscopy, including the steps of: provision of a substrate which has multiple Crithidia luciliae cells, incubation of the substrate with the patient sample which potentially has the autoantibodies, incubation of the substrate with secondary antibodies which have each been labelled with a preferably green fluorescent dye, acquisition of a fluorescence image of the substrate, identification by means of a first pretrained convolutional neural network of respective sub-images in the one fluorescence image that each represent a Crithidia luciliae cell, furthermore respective processing of at least one subset of the respective sub-images by means of a second pretrained convolutional neural network for determining respective binding measures which indicate a respective extent of a binding of autoantibodies in a respective kinetopType: ApplicationFiled: September 17, 2021Publication date: March 17, 2022Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Stefan Gerlach, Jens Krauth, Christian Marzahl, Christopher Krause, Maick Danckwardt, Melanie Hahn, Jörn Voigt
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Publication number: 20210272279Abstract: An image processing method is provided for displaying cells from a plurality of pathology images or overall images. A respective overall image represents a respective patient tissue sample or a respective patient cell sample.Type: ApplicationFiled: March 2, 2021Publication date: September 2, 2021Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Christian Marzahl, Stefan Gerlach, Joern Voigt, Christine Kroeger
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Publication number: 20210245152Abstract: A method is useful for automated detection of antibodies in a liquid biological sample with an antigen chip having antigen spots which are applied thereon and which have an identical, common dye. The antigen spots form respective antigen spot sets which form corresponding respective, regular antigen spot patterns. Furthermore, reference spots comprising the identical dye are applied, and form a reference spot set which forms a regular reference pattern. The reference pattern differs with respect to its regularity from the antigen spot patterns. Through a first image information item which represents a color of the reference spots and of the antigen spots due to the identical, first dye and through a second image information item which represents a potential color of the antigen spots due to a second dye after an incubation, binding of antibodies of the biological sample to respective antigen types is then determined by image processing.Type: ApplicationFiled: June 17, 2019Publication date: August 12, 2021Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Katja Morgenroth, Vanessa Viertel, Ulf Steller, Stefan Gerlach, Christian Marzahl, Jörn Voigt, Winfried Stöcker
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Publication number: 20210019883Abstract: A method is for detecting respective potential presence of respective different antinuclear antibody fluorescence pattern types on a biological cell substrate including human epithelioma cells, including: acquiring a first image which represents staining of the cell substrate by a first fluorescent dye, and acquiring a second image which represents staining of the cell substrate by a second fluorescent dye, detecting, on the basis of the first image, respective image segments which in each case represent at least one mitotic cell, selecting, on the basis of the detected image segments, subimages of the first image and subimages corresponding thereto of the second image and detecting, on the basis of the selected subimages of the first image and of the selected subimages of the second image, respective actual presence of respective cellular fluorescence pattern types by means of a convolutional neural network.Type: ApplicationFiled: July 2, 2020Publication date: January 21, 2021Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Jens KRAUTH, Christopher Krause, Joern Voigt, Melanie Hahn, Christian Marzahl, Stefan Gerlach
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Publication number: 20200300764Abstract: A method and a device are useful for detecting a binding of autoantibodies from a patient sample to double-stranded deoxyribonucleic acid (DNA) using Crithidia luciliae cells by fluorescence microscopy and by digital image processing.Type: ApplicationFiled: March 17, 2020Publication date: September 24, 2020Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Stefan Gerlach, Christian Marzahl, Maick Danckwardt, Joern Voigt
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Publication number: 20200011862Abstract: An antigen chip is described, the latter comprising a plane substrate surface; and antigen spots, which are applied in a predetermined pattern on the substrate surface and which contain a first fluorescence dye. Further, an apparatus and a method for detecting antibodies in a sample are provided. Even further, the application relates to kit for use in a method for detecting antibodies in a sample.Type: ApplicationFiled: July 3, 2019Publication date: January 9, 2020Inventors: Katja MORGENROTH, Vanessa VIERTEL, Winfried STOECKER, Ulf STELLER, Stefan GERLACH, Christian MARZAHL, Joern VOIGT