Patents by Inventor Johan Adriaan Marc Grooten
Johan Adriaan Marc Grooten has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9206213Abstract: A method of preparing a compound of formula (III): (M)x-(S)y-(M?)z??(III) wherein x is from 1 to 6, y is from 1 to 12, z is from 0 to 10, each M and each M? is independently a mycolic acid residue including a ?-hydroxy acid moiety and each S is a monosaccharide unit; the method comprising reacting one or more mycolic acids with one or more saccharide units wherein the hydroxyl group of each ?-hydroxy acid moiety is protected prior to reaction with the one or more saccharide units.Type: GrantFiled: December 9, 2013Date of Patent: December 8, 2015Assignee: Bangor UniversityInventors: Mark Stephen Baird, Juma'a Raheem Najeem Al Dulayymi, Johan Adriaan Marc Grooten, Seppe Vander Beken, Maximilliano Maza-Inglesias
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Patent number: 8889894Abstract: A compound of formula (I) for use in the treatment of a disease of the immune system; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R2, R3 and R4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkenylene, arylene, alkylarylene, cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester and thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C—OR5; wherein R5 is alkyl or haloalkyl, and A is O,Type: GrantFiled: April 22, 2009Date of Patent: November 18, 2014Assignees: Bangor University, Universiteit GentInventors: Mark Stephen Baird, Juma′ a Raheem Najeem Al-Dulayy-mi, Cornelias Theunissen, Gani Koza, Seppe Vander-Beken, Johan Adriaan Marc Grooten
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Publication number: 20140178434Abstract: A method of preparing a compound of formula (III): (M)x-(S)y-(M?)z??(III) wherein x is from 1 to 6, y is from 1 to 12, z is from 0 to 10, each M and each M? is independently a mycolic acid residue including a ?-hydroxy acid moiety and each S is a monosaccharide unit; the method comprising reacting one or more mycolic acids with one or more saccharide units wherein the hydroxyl group of each ?-hydroxy acid moiety is protected prior to reaction with the one or more saccharide units.Type: ApplicationFiled: December 9, 2013Publication date: June 26, 2014Applicant: Bangor UniversityInventors: Mark Stephen Baird, Juma'a Raheem Najeem Al Dulayymi, Johan Adriaan Marc Grooten, Seppe Vander Beken, Maximilliano Maza-Inglesias
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Patent number: 8728515Abstract: A compound of formula (I) for use as an adjuvant in vaccination; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R2, R3 and R4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, alkylarylene or cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester, thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C—OR5; wherein R5 is alkyl or haloalkyl, and A is S, O or NR6, wherein R6Type: GrantFiled: April 22, 2009Date of Patent: May 20, 2014Assignees: Bangor University, Universiteit GentInventors: Mark Stephen Baird, Juma' a Raheem Najeem Al-Dulayymi, Cornelia Theunissen, Gani Koza, Seppe Vander Beken, Johan Adriaan Marc Grooten
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Publication number: 20120045478Abstract: A method of preparing a compound of formula (III): wherein x is from 1 to 6, y is from 1 to 12, z is from 0 to 10, each M and each M? is independently a mycolic acid residue including a ?-hydroxy acid moiety and each S is a monosaccharide unit; the method comprising reacting one or more mycolic acids with one or more saccharide units wherein the hydroxyl group of each ?-hydroxy acid moiety is protected prior to reaction with the one or more saccharide units.Type: ApplicationFiled: January 29, 2010Publication date: February 23, 2012Applicant: BANGOR UNIVERSITYInventors: Mark Stephen Baird, Juma'a Raheem Najeem Al Dulayymi, Johan Adriaan Marc Grooten, Seppe Vander Beken, Maximilliano Maza-Inglesias
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Publication number: 20020182178Abstract: The invention relates to the use of IL-15 or active variants thereof and/or IL-15 activity enhancing compounds for the manufacture of a pharmaceutical composition for manipulating memory cells of the immune system, such as manipulating viability ad/or responsiveness of said memory cells. The IL-15 activity enhancing compound is for example lipopolysaccharide (LPS). The invention further relates to the use of IL-15 inhibiting or eliminating compounds for the manufacture of a pharmaceutical composition for manipulating memory cells of the immune system. Such inhibiting or eliminating compounds are for example anti-IL-15 antibodies, anti-IL-15R&agr; antibodies, fragments of these antibodies, e.g. the Fab or F(ab′)2 fragment, soluble IL-15R&agr;, fusion proteins consisting of soluble IL-15R&agr;, and Fc fragment, compounds, e.g. peptides, binding-and/or inhibiting functional IL-15 receptor, IL-15 antisense oligonucleotides.Type: ApplicationFiled: October 18, 2001Publication date: December 5, 2002Inventors: Johan Adriaan Marc Grooten, Hans Peter Raf Dooms, Walter Charles Fiers
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Patent number: 6344192Abstract: The invention relates to the use of IL-15 or active variants thereof and/or IL-15 activity enhancing compounds for the manufacture of a pharmaceutical composition for manipulating memory cells of the immune system, such as manipulating viability ad/or responsiveness of said memory cells. The IL-15 activity enhancing compound is for example lipopolysaccharidc (LPS). The invention further relates to the use of IL-15 inhibiting or eliminating compounds for the manufacture of a pharmaceutical composition for manipulating memory cells of the immune system. Such inhibiting or eliminating compounds are for example anti-IL-15 antibodies, anti-IL-15R&agr; antibodies, fragments of these antibodies, e.g. the Fab or F(ab′)2 fragment, soluble IL-15R&agr;, fusion proteins consisting of soluble IL-15R&agr;, and Fc fragment, compounds, e.g. peptides, binding and/or inhibiting functional IL-15 receptor, IL-15 antisense oligonucleotides.Type: GrantFiled: August 23, 1999Date of Patent: February 5, 2002Assignee: Vlaams Interuniversitair Instituut voor BiotechnologieInventors: Johan Adriaan Marc Grooten, Hans Peter Raf Dooms, Walter Charles Fiers