Abstract: The invention relates to a multi-compartment syringe comprising an ampoule having a plunger, a sealing stopper and at least one separating stopper between the plunger and the sealing stopper, and a needle holder consisting of a collar, a neck for an injection needle, a shaft between the collar and the neck and a by-pass means in the inner wall of the shaft, the space in the shaft of the needle holder being at least slightly longer than the sealing stopper, the ampoule wall comprising a liquid by-pass means through which the liquid behind the separating stopper or stoppers can reach the substance in front of the separating stopper or front separating stopper and can mix with same or can dissolve it, the ampoule, before use of the syringe, comprising an empty space in front of the sealing stopper.