Abstract: The present invention relates to compositions in the form of a clear solution comprising ciclosporin with low residual water content and 1-perfluorobutyl-pentane. The compositions may be used for topical administration to the eye.

Abstract: A method for ensuring the quality of a multi-component mixture in a system for rock reinforcement is described herein. The system comprises a first and a second channel for a respective first and second component intended for injection in a rock hole. The respective channel comprises a pump and a container intended for the respective component. The method comprises the steps of pumping of the respective component from the respective container through the respective channel and continuously comparing the flow of the first component in the first channel with the flow of the second component in the second channel. The method further comprises the step of controlling the pumps individually, based on the comparison of the flows, in such a way that a deviation from a pre-defined volume ratio between the first component and the second component in the mixture is below a pre-defined first threshold.

Abstract: The present invention relates to compositions in the form of a clear solution comprising ciclosporin with low residual water content and 1-perfluorobutyl-pentane. The compositions may be used for topical administration to the eye.

Abstract: An oil-in-water emulsion composition contains a) at least one liquid continuous aqueous phase (X) containing alcohol in water; b) at least one dispersed fatty phase (Y), of at least one oil; c) stabilizing particles (Z), being selected from solid particles and soft-gel particles. The oil-in-water emulsion composition is useful as a topical sanitizing composition.

Abstract: The invention discloses a method for preparation of polyoxyethylene 1,4-sorbitan fatty acid ester, such as Polysorbate 80, by a reaction of polyoxyethylene 1,4-sorbitan with a fatty acid chloride, and polyoxyethylene 1,4-sorbitan fatty acid esters obtainable by this method.

Abstract: A method for ensuring the quality of a multi-component mixture in a system for rock reinforcement is described herein. The system comprises a first and a second channel for a respective first and second component intended for injection in a rock hole. The respective channel comprises a pump and a container intended for the respective component. The method comprises the steps of pumping of the respective component from the respective container through the respective channel and continuously comparing the flow of the first component in the first channel with the flow of the second component in the second channel. The method further comprises the step of controlling the pumps individually, based on the comparison of the flows, in such a way that a deviation from a pre-defined volume ratio between the first component and the second component in the mixture is below a pre-defined first threshold.

Abstract: The present invention relates to compositions in the form of a clear solution comprising ciclosporin with low residual water content and 1-perfluorobutyl-pentane. The compositions may be used for topical administration to the eye.

Abstract: The present invention relates to compositions in the form of a clear solution comprising ciclosporin with low residual water content and 1-perfluorobutylpentane. The compositions may be used for topical administration to the eye.

Abstract: The present invention relates to compositions in the form of a clear solution comprising ciclosporin with low residual water content and 1-perfluorobutylpentane. The compositions may be used for topical administration to the eye.

Abstract: The present invention relates to a microemulsion comprising: 1-98 wt % of at least one polar lipid selected from polyglycerol fatty acid esters; 1-98 wt % of at least one emollient, not being a polyglycerolfatty acid ester; 0.1-3 wt % of at least one polar solvent; and 0-10 wt % of a surfactant, not being a polyglycerol fatty acid ester. The present invention further relates to said microemulsion for use as a medicament, and for use in the treatment and prevention of dry mucosa or prevention of airborne particles reaching topical mucosal membranes of a mammal. The present invention also relates to a liquid composition comprising said microemulsion, and an applicator device comprising said microemulsion.

Abstract: Single phase pharmaceutical compositions for topical application, in addition to kits and methods of use and administration are provided. The compositions comprise a biologically active agent; a delivery vehicle comprising at least a non-polymeric crystallization inhibitor and a film-former; and a volatile solvent; wherein the biologically active agent is present in the composition in a subsaturated state, the biologically active agent is present in the delivery vehicle in a supersaturated state, and the crystallization inhibitor is capable of delaying crystallization of the biologically active agent in the delivery vehicle. Biologically active agents include terbinafine and acyclovir. Treatments for onychomycosis and Varicella zoster infection, HSV-I infection or HSV-2 infection are provided.

Abstract: A topical composition comprising a dihydropyridine calcium antagonist, a stiffening agent and a release modifier. The stiffening agent comprises a fatty alcohol, a fatty acid sorbitane ester, or a fatty acid glycerol ester, having a hydrocarbon chain containing 12 to 22 carbon atoms and having a melting point of about 45 to 750° C. The release modifier comprises a fatty alcohol, a fatty alcohol glycol ether, a fatty acid alkyl ester, a fatty acid glycerol ester, or a fatty acid sorbitane ester, having a hydrocarbon chain containing 12 to 18 carbon atoms and having a melting point of about ?10 to 400° C. Use of such a composition for the treatment and/or prophylaxis of a dermal or mucosal disorder, preferably an anorectal disorder associated with high anal pressure or anal sphincter spasm.

Abstract: A topical composition comprising a dihydropyridine calcium antagonist, a stiffening agent and a release modifier. The stiffening agent comprises a fatty alcohol, a fatty acid sorbitane ester, or a fatty acid glycerol ester, having a hydrocarbon chain containing 12 to 22 carbon atoms and having a melting point of about 45 to 750° C. The release modifier comprises a fatty alcohol, a fatty alcohol glycol ether, a fatty acid alkyl ester, a fatty acid glycerol ester, or a fatty acid sorbitane ester, having a hydrocarbon chain containing 12 to 18 carbon atoms and having a melting point of about ?10 to 400° C. Use of such a composition for the treatment and/or prophylaxis of a dermal or mucosal disorder, preferably an anorectal disorder associated with high anal pressure or anal sphincter spasm.

Abstract: Single phase pharmaceutical compositions for topical application, in addition to kits and methods of use and administration are provided. The compositions comprise a biologically active agent; a delivery vehicle comprising at least a non-polymeric crystallization inhibitor and a film-former; and a volatile solvent; wherein the biologically active agent is present in the composition in a subsaturated state, the biologically active agent is present in the delivery vehicle in a supersaturated state, and the crystallization inhibitor is capable of delaying crystallization of the biologically active agent in the delivery vehicle. Biologically active agents include terbinafine and acyclovir. Treatments for onychomycosis and Varicella zoster infection, HSV-1 infection or HSV-2 infection are provided.