Abstract: Novel methods for the use of modulators to modulate an activity of a neural stem cell or a neural progenitor cell in vivo or in vitro are provided. The disclosure provides novel methods for the treatment of neurological diseases and disorders.

Abstract: Disclosed are nucleic acids, peptides, proteins, fusion proteins, antibodies, affibodies, and other reagents that disrupt interactions between ephrins and ephrin receptors. Specifically disclosed are reagents comprising soluble ephrins and soluble ephrin receptors. Also disclosed are methods of using these reagents for the increasing or decreasing cellular proliferation, for example, for alleviation, prevention, or treatment of one or more symptoms of a disease or disorder, including a disease or disorder of the gastrointestinal tract, reproductive tract, skin, or hematopoietic system.

Abstract: The present invention relates to an electro-pneumatic positioner for use with a pneumatically controlled two-chamber actuator comprising a first valve unit (10) comprising a first air supply valve (14) and a first air outlet valve (37) connected to a conduit (30, 38, 50), which in turn is connectable to a chamber of the actuator, a second valve unit (12) comprising a second air supply valve (14′) and a second air outlet valve (37′) connected to a conduit (30′, 38′, 50′), which in turn is connected to a second chamber of the actuator; a first control device (60, 74) acting on the first air supply valve, which first control device comprises a first control valve (60); a second control device (60′, 76) acting on the said second air supply valve, which second control device comprises a second control valve (60′).

Abstract: A tightening device for shoelaces and other elongated pliable elements having free ends includes a casing and two slides mounted in said casing. Extending through the casing are two holes which are mutually spaced apart and disposed perpendicularly to the direction of slide movement and through which the free ends can be threaded. The slides are movable in the casing from a first position in which they each block a respective hole in the casing, to a second position in which they each expose their respective hole. The slides are also spring-biased towards said first position for securing an element inserted through the holes, in coaction with the casing. The holes penetrating the casing define a right angle with each other.