Abstract: The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: A crankshaft (1) for a crankcase scavenged two stroke piston engine (2) is disclosed. The crankshaft (1) is configured to rotate around a rotation axis (ax) during operation. The crankshaft (1) comprises a crankpin (3) configured to move in a crank plane (cp) during operation, and a first and a second counterweight (5, 7) arranged on either side (S1, S2) of the crank plane (cp). The first counterweight (5) has a first outer radius (r1) measured from the rotation axis (ax) and the second counterweight (7) has a second outer radius (r2) measured from the rotation axis (ax). The first outer radius (r1) is smaller than the second outer radius (r2). The present disclosure further relates to a power unit (10), a crankcase scavenged two stroke piston engine (2), and a hand-held power tool (20).

Abstract: A two-stroke engine piston (1) is disclosed comprising a piston top (3), a mantle surface (5), a stratified scavenging channel (7) in the mantle surface (5), and a weight reduction space (9) arranged between the piston top (3) and the stratified scavenging channel (7). The weight reduction space (9) has a largest first axial extent (a1) at the mantle surface (5) and a second axial extent (a2) radially inside the mantle surface (5), and wherein the second axial extent (a2) is greater than the largest first axial extent (a1). The present disclosure further relates to an engine (30), a hand-held tool (40), and a method of manufacturing an engine piston (1).

Abstract: A crankshaft (1) for a crankcase scavenged two stroke piston engine (2) is disclosed. The crankshaft (1) is configured to rotate around a rotation axis (ax) during operation. The crankshaft (1) comprises a crankpin (3) configured to move in a crank plane (cp) during operation, and a first and a second counterweight (5, 7) arranged on either side (S1, S2) of the crank plane (cp). The first counterweight (5) has a first outer radius (r1) measured from the rotation axis (ax) and the second counterweight (7) has a second outer radius (r2) measured from the rotation axis (ax). The first outer radius (r1) is smaller than the second outer radius (r2). The present disclosure further relates to a power unit (10), a crankcase scavenged two stroke piston engine (2), and a hand-held power tool (20).

Abstract: A two-stroke engine piston (1) is disclosed comprising a piston top (3), a mantle surface (5), a stratified scavenging channel (7) in the mantle surface (5), and a weight reduction space (9) arranged between the piston top (3) and the stratified scavenging channel (7). The weight reduction space (9) has a largest first axial extent (a1) at the mantle surface (5) and a second axial extent (a2) radially inside the mantle surface (5), and wherein the second axial extent (a2) is greater than the largest first axial extent (a1). The present disclosure further relates to an engine (30), a hand-held tool (40), and a method of manufacturing an engine piston (1).