Abstract: In a combined system, a magnetic resonance (MR) scanner includes a magnet configured to generate a static magnetic field at least in a MR examination region from which MR data are acquired. Radiation detectors are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region. The radiation detectors include electron multiplier elements having a direction of electron acceleration arranged substantially parallel or anti-parallel with the static magnetic field. In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces disposed on opposite sides of a magnetic resonance examination region, and the radiation detectors include first and second arrays of radiation detectors disposed with the first and second spaced apart magnet pole pieces.

Abstract: We provide a radiotherapeutic apparatus comprising a patient support, magnetic coils disposed around the patient support for creating a magnetic field therewithin, a radiation source producing a beam of radiation directed toward the patient support and mounted on a rotatable support thereby to rotate the radiation source around the patient support, a slip ring for conveying electrical power to the radiation source and located around the patient support, including at least one electrical interruption therein. This creates a slip ring in which there is no continuous circumferential path, and one in which the current is therefore forced to take a route via one side or the other.

Abstract: A generally cylindrical set of coil windings includes primary coil windings and shield coil windings at a larger radial position than the primary coil windings, and an arcuate or annular central gap that is free of coil windings, has an axial extent of at least ten centimeters, and spans at least a 180° angular interval. Connecting conductors disposed at each edge of the central gap electrically connect selected primary and secondary coil windings. In a scanner setting, a main magnet is disposed outside of the generally cylindrical set of coil windings. In a hybrid scanner setting, an annular ring of positron emission tomography (PET) detectors is disposed in the central gap of the generally cylindrical set of coil windings.

Abstract: In a combined system, a magnetic resonance (MR) scanner includes a magnet configured to generate a static magnetic field at least in a MR examination region from which MR data are acquired. Radiation detectors are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region. The radiation detectors include electron multiplier elements having a direction of electron acceleration arranged substantially parallel or anti-parallel with the static magnetic field. In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces disposed on opposite sides of a magnetic resonance examination region, and the radiation detectors include first and second arrays of radiation detectors disposed with the first and second spaced apart magnet pole pieces.

Abstract: In a combined system, a magnetic resonance (MR) scanner includes a magnet configured to generate a static magnetic field at least in a MR examination region from which MR data are acquired. Radiation detectors are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region. The radiation detectors include electron multiplier elements having a direction of electron acceleration arranged substantially parallel or anti-parallel with the static magnetic field. In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces disposed on opposite sides of a magnetic resonance examination region, and the radiation detectors include first and second arrays of radiation detectors disposed with the first and second spaced apart magnet pole pieces.

Abstract: A generally cylindrical set of coil windings includes primary coil windings and shield coil windings at a larger radial position than the primary coil windings, and an arcuate or annular central gap that is free of coil windings, has an axial extent of at least ten centimeters, and spans at least a 180° angular interval. Connecting conductors disposed at each edge of the central gap electrically connect selected primary and secondary coil windings. In a scanner setting, a main magnet is disposed outside of the generally cylindrical set of coil windings. In a hybrid scanner setting, an annular ring of positron emission tomography (PET) detectors is disposed in the central gap of the generally cylindrical set of coil windings.

Abstract: A generally cylindrical set of coil windings includes primary coil windings and shield coil windings at a larger radial position than the primary coil windings, and an arcuate or annular central gap that is free of coil windings, has an axial extent of at least ten centimeters, and spans at least a 180° angular interval. Connecting conductors disposed at each edge of the central gap electrically connect selected primary and secondary coil windings. In a scanner setting, a main magnet is disposed outside of the generally cylindrical set of coil windings. In a hybrid scanner setting, an annular ring of positron emission tomography (PET) detectors is disposed in the central gap of the generally cylindrical set of coil windings.

Abstract: In a combined system, a magnetic resonance (MR) scanner includes a magnet configured to generate a static magnetic field at least in a MR examination region from which MR data are acquired. Radiation detectors are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region. The radiation detectors include electron multiplier elements having a direction of electron acceleration arranged substantially parallel or anti-parallel with the static magnetic field. In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces disposed on opposite sides of a magnetic resonance examination region, and the radiation detectors include first and second arrays of radiation detectors disposed with the first and second spaced apart magnet pole pieces.

Abstract: In a combined system, a magnetic resonance (MR) scanner includes a magnet configured to generate a static magnetic field at least in a MR examination region from which MR data are acquired. Radiation detectors are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region. The radiation detectors include electron multiplier elements having a direction of electron acceleration arranged substantially parallel or anti-parallel with the static magnetic field. In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces disposed on opposite sides of a magnetic resonance examination region, and the radiation detectors include first and second arrays of radiation detectors disposed with the first and second spaced apart magnet pole pieces.

Abstract: A generally cylindrical set of coil windings (10, 30, 80) includes primary coil windings (12, 32, 82) and shield coil windings (14, 34, 84) at a larger radial position than the primary coil windings, and an arcuate or annular central gap (16, 36, 86) that is free of coil windings, has an axial extent (W) of at least ten centimeters, and spans at least a 180° angular interval. Connecting conductors (24, 44, 94) disposed at each edge of the central gap electrically connect selected primary and secondary coil windings. In a scanner setting, a main magnet (62, 64) is disposed outside of the generally cylindrical set of coil windings. In a hybrid scanner setting, an annular ring of positron emission tomography (PET) detectors (66) is disposed in the central gap of the generally cylindrical set of coil windings.

Abstract: A generally cylindrical set of coil windings includes primary coil windings and shield coil windings at a larger radial position than the primary coil windings, and an arcuate or annular central gap that is free of coil windings, has an axial extent of at least ten centimeters, and spans at least a 180° angular interval. Connecting conductors disposed at each edge of the central gap electrically connect selected primary and secondary coil windings. In a scanner setting, a main magnet is disposed outside of the generally cylindrical set of coil windings. In a hybrid scanner setting, an annular ring of positron emission tomography (PET) detectors is disposed in the central gap of the generally cylindrical set of coil windings.

Abstract: In a combined system, a magnetic resonance (MR) scanner includes a magnet configured to generate a static magnetic field at least in a MR examination region from which MR data are acquired. Radiation detectors are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region. The radiation detectors include electron multiplier elements having a direction of electron acceleration arranged substantially parallel or anti-parallel with the static magnetic field. In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces disposed on opposite sides of a magnetic resonance examination region, and the radiation detectors include first and second arrays of radiation detectors disposed with the first and second spaced apart magnet pole pieces.

Abstract: In a combined system, a magnetic resonance (MR) scanner includes a magnet (10, 110) configured to generate a static magnetic field (B0) at least in a MR examination region (12) from which MR data are acquired. Radiation detectors (40, 41, 140) are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region (70). The radiation 5 detectors include electron multiplier elements (60, 160) having a direction of electron acceleration (ae) arranged substantially parallel or anti-parallel with the static magnetic field (B0). In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces (14, 15) disposed on opposite sides of a magnetic 10 resonance examination region, and the radiation detectors include first and second arrays (40, 41) of radiation detectors disposed with the first and second spaced apart magnet pole pieces.

Abstract: In a combined system, a magnetic resonance (MR) scanner includes a magnet (10, 110) configured to generate a static magnetic field (B0) at least in a MR examination region (12) from which MR data are acquired. Radiation detectors (40, 41, 140) are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region (70). The radiation 5 detectors include electron multiplier elements (60, 160) having a direction of electron acceleration (ae) arranged substantially parallel or anti-parallel with the static magnetic field (B0). In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces (14, 15) disposed on opposite sides of a magnetic 10 resonance examination region, and the radiation detectors include first and second arrays (40, 41) of radiation detectors disposed with the first and second spaced apart magnet pole pieces.

Abstract: A generally cylindrical set of coil windings (10, 30, 80) includes primary coil windings (12, 32, 82) and shield coil windings (14, 34, 84) at a larger radial position than the primary coil windings, and an arcuate or annular central gap (16, 36, 86) that is free of coil windings, has an axial extent (W) of at least ten centimeters, and spans at least a 180° angular interval. Connecting conductors (24, 44, 94) disposed at each edge of the central gap electrically connect selected primary and secondary coil windings. In a scanner setting, a main magnet (62, 64) is disposed outside of the generally cylindrical set of coil windings. In a hybrid scanner setting, an annular ring of positron emission tomography (PET) detectors (66) is disposed in the central gap of the generally cylindrical set of coil windings.

Abstract: In a magnetic resonance scanner, a radio frequency transmit coil (30, 30?) includes a plurality of parallel rods rungs (32, 32?, 32?) at least partially surrounding an examination region. The radio frequency transmit coil is configured to transmit radio frequency energy into the examination region at or near a magnetic resonance frequency. A plurality of magnetic resonance receive coils (40) are disposed with the radio frequency transmit coil. For decoupling, each magnetic resonance receive coil is positioned substantially centered on a proximate one rod or rung or proximate plurality of neighboring rods or rungs of the radio frequency transmit coil.

Abstract: Systems and methods for monitoring in vivo release of therapeutic and/or diagnostic agents, e.g., drugs, are provided. The disclosed systems and methods use a contrast agent and Overhauser-enhanced nuclear magnetic resonance (NMR) to monitor and/or measure the concentration and distribution of the contrast agent. Provided the contrast agent and the therapeutic/diagnostic agent have similar pharmaco-kinetics, the disclosed system/method may also be used to monitor and/or measure the concentration of such therapeutic/diagnostic agent (e.g., a drug), e.g., in the form of a volume-averaged signal and/or dynamic two-dimensional or three-dimensional images. In exemplary embodiments of the present disclosure, the therapeutic/diagnostic agent and the contrast agent are introduced to the body in an encapsulated form, e.g., within hollow nanoparticles.