Patents by Inventor Johann Winkler
Johann Winkler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220315650Abstract: The present disclosure relates to methods for selectively reducing CysL97 in a preparation of IL-17 antibodies or antigen binding fragments thereof (e.g., a preparation of secukinumab antibodies) that have been recombinantly produced by mammalian cells. Also provided are purified preparations of IL-17 antibodies or antigen binding fragments thereof produced by such methods, e.g, purified preparations of secukinumab, wherein the level of intact IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 90%, as measured by sodium dodecyl sulfate capillary electrophoresis (CE-SDS), and wherein the level of activity of IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 92%, as measured by cation exchange chromatograph (CEX).Type: ApplicationFiled: March 1, 2022Publication date: October 6, 2022Inventors: Markus HEITZMANN, Johann WINKLER
-
Patent number: 11292833Abstract: The present disclosure relates to methods for selectively reducing CysL97 in a preparation of IL-17 antibodies or antigen binding fragments thereof (e.g., a preparation of secukinumab antibodies) that have been recombinantly produced by mammalian cells. Also provided are purified preparations of IL-17 antibodies or antigen binding fragments thereof produced by such methods, e.g, purified preparations of secukinumab, wherein the level of intact IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 90%, as measured by sodium dodecyl sulfate capillary electrophoresis (CE-SDS), and wherein the level of activity of IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 92%, as measured by cation exchange chromatograph (CEX).Type: GrantFiled: December 21, 2015Date of Patent: April 5, 2022Assignee: NOVARTIS AGInventors: Markus Heitzmann, Johann Winkler
-
Patent number: 10170231Abstract: The present invention relates to a choke with two coils and a core for interleaved applications in step-up or step-down circuits or power factor compensation circuits. The core comprises several core sections with several lateral legs and a middle leg, whereby the core is designed such, that a coupling factor k of the two coils is smaller than 3%-5%. Furthermore, the core is designed such, that the core section form two loops with the middle leg as a common section, whereby each of the two coils lies on different loops outside of the common section. The lateral legs have a cross section A1 and the middle leg for the common section has a cross section A2<2×A1.Type: GrantFiled: March 31, 2015Date of Patent: January 1, 2019Assignee: Sumida Components & Modules GmbHInventors: Johann Winkler, Ernst Holzinger, Robert Ludwig, Iyad Kebaisy, Herbert Jungwirth
-
Publication number: 20170369567Abstract: The present disclosure relates to methods for selectively reducing CysL97 in a preparation of IL-17 antibodies or antigen binding fragments thereof (e.g., a preparation of secukinumab antibodies) that have been recombinantly produced by mammalian cells. Also provided are purified preparations of IL-17 antibodies or antigen binding fragments thereof produced by such methods, e.g., purified preparations of secukinumab, wherein the level of intact IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 90%, as measured by sodium dodecyl sulfate capillary electrophoresis (CE-SDS), and wherein the level of activity of IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 92%, as measured by cation exchange chromatograph (CEX).Type: ApplicationFiled: December 21, 2015Publication date: December 28, 2017Inventors: Markus Heitzmann, Johann Winkler
-
Patent number: 9852838Abstract: A rod-shaped magnetic core element, having a first end with a spherical or cylindrical recess or a spherical or cylindrical connecting protrusion, and a second end with a spherical or cylindrical recess or a spherical or cylindrical connecting protrusion so that a bent connection of at least two magnetic core elements is variably adjustable. Magnetic core elements comprising spherical or cylindrical magnetic core ends of this type allow a nearly gap-free construction with little magnetic leakage due to slightly larger end surfaces in comparison with ferrite rods having beveled plane end section surfaces. The enlarged end surface of the spherical surface advantageously allows a more stable connection of individual magnetic core elements without adhesive bonding. This allows the construction of flexible, multiple-member and inexpensive rod core coils and antennae.Type: GrantFiled: November 3, 2014Date of Patent: December 26, 2017Assignee: Sumida Components & Modules GMBHInventor: Johann Winkler
-
Publication number: 20150287512Abstract: The present invention relates to a choke with two coils and a core for interleaved applications in step-up or step-down circuits or power factor compensation circuits. The core comprises several core sections with several lateral legs and a middle leg, whereby the core is designed such, that a coupling factor k of the two coils is smaller than 3%-5%. Furthermore, the core is designed such, that the core section form two loops with the middle leg as a common section, whereby each of the two coils lies on different loops outside of the common section. The lateral legs have a cross section A1 and the middle leg for the common section has a cross section A2<2×A1.Type: ApplicationFiled: March 31, 2015Publication date: October 8, 2015Inventors: Johann WINKLER, Ernst HOLZINGER, Robert LUDWIG, Iyad KEBAISY, Herbert JUNGWIRTH
-
Publication number: 20150123761Abstract: A rod-shaped magnetic core element, having a first end with a spherical or cylindrical recess or a spherical or cylindrical connecting protrusion, and a second end with a spherical or cylindrical recess or a spherical or cylindrical connecting protrusion so that a bent connection of at least two magnetic core elements is variably adjustable. Magnetic core elements comprising spherical or cylindrical magnetic core ends of this type allow a nearly gap-free construction with little magnetic leakage due to slightly larger end surfaces in comparison with ferrite rods having beveled plane end section surfaces. The enlarged end surface of the spherical surface advantageously allows a more stable connection of individual magnetic core elements without adhesive bonding. This allows the construction of flexible, multiple-member and inexpensive rod core coils and antennae.Type: ApplicationFiled: November 3, 2014Publication date: May 7, 2015Inventor: Johann WINKLER
-
Patent number: 8378085Abstract: This invention provides an isolated mutant atpE protein and departing from said mutant atpE protein the identification of an ATPase binding domain. This invention also provides related nucleic acids, vectors, host cells, pharmaceutical compositions and articles of manufacture. This invention further provides methods for determining whether a test compound interacts with an atpE protein, i.e. with the ATPase binding domain of the present invention, as well as pharmaceuticals compositions comprising said test compound, in particular as antimicrobials, more particular as antimycobacterial agent, even more particular for treating tuberculosis in a subject.Type: GrantFiled: November 29, 2011Date of Patent: February 19, 2013Assignee: Janssen Pharmaceutica N.V.Inventors: Koenraad Jozef Lodewijk Marcel Andries, Hinrich Wilhelm Helmut Gohlmann, Jean-Marc Edmond Fernand Marie Neefs, Peter Karel Maria Verhasselt, Johann Winkler, Marc Rene De Jonge, Lucien Maria Henricus Koymans
-
Publication number: 20120219964Abstract: This invention provides an isolated mutant atpE protein and departing from said mutant atpE protein the identification of an ATPase binding domain. This invention also provides related nucleic acids, vectors, host cells, pharmaceutical compositions and articles of manufacture. This invention further provides methods for determining whether a test compound interacts with an atpE protein, i.e. with the ATPase binding domain of the present invention, as well as pharmaceuticals compositions comprising said test compound, in particular as antimicrobials, more particular as antimycobacterial agent, even more particular for treating tuberculosis in a subject.Type: ApplicationFiled: November 29, 2011Publication date: August 30, 2012Inventors: Koenraad Jozef Lodewijk Marcel Andries, Hinrich Wilhelm Helmut Göhlmann, Jean-Marc Edmond Fernand Marie Neefs, Peter Karel Maria Verhasselt, Johann Winkler, Marc Rene De Jonge, Lucien Maria Henricus Koymans
-
Patent number: 8088891Abstract: This invention provides an isolated mutant atpE protein and departing from said mutant atpE protein the identification of an ATPase binding domain. This invention also provides related nucleic acids, vectors, host cells, pharmaceutical compositions and articles of manufacture. This invention further provides methods for determining whether a test compound interacts with an atpE protein, i.e. with the ATPase binding domain of the present invention, as well as pharmaceuticals compositions comprising said test compound, in particular as antimicrobials, more particular as antimycobacterial agent, even more particular for treating tuberculosis in a subject.Type: GrantFiled: September 28, 2005Date of Patent: January 3, 2012Assignee: Janssen Pharmaceutica N.V.Inventors: Koenraad Jozef Lodewijk Marcel Andries, Hinrich Wilhelm Helmut Göhlmann, Jean-Marc Edmond Fernand Marie Neefs, Peter Karel Maria Verhasselt, Johann Winkler, Marc René De Jonge, Lucien Maria Henricus Koymans
-
Publication number: 20090298874Abstract: This invention provides an isolated mutant atpE protein and departing from said mutant atpE protein the identification of an ATPase binding domain. This invention also provides related nucleic acids, vectors, host cells, pharmaceutical compositions and articles of manufacture. This invention further provides methods for determining whether a test compound interacts with an atpE protein, i.e. with the ATPase binding domain of the present invention, as well as pharmaceuticals compositions comprising said test compound, in particular as antimicrobials, more particular as antimycobacterial agent, even more particular for treating tuberculosis in a subject.Type: ApplicationFiled: September 28, 2005Publication date: December 3, 2009Inventors: Koenraad Jozef Lodewijk Marcel Andries, Hinrich Wilhelm Helmut Göhlmann, Jean-Marc Edmond Fernand Marie Neefs, Peter Karel Maria Verhasselt, Johann Winkler, Marc René De Jonge, Lucien Marie Henricus Koymans
-
Patent number: 7042169Abstract: A description is given of a gas-discharge lamp base (11) with a housing comprising an upper part (10) and a cover (40), a support (16) accommodated in the housing for receiving the components, with a transformer, with inductances connected in series with the lamp (1) and a capacitance connected in parallel with the lamp (1), the transformer comprising a bar transformer (23). This construction permits particularly efficient production, because the support can be constructed as a simple leadframe which permits automatic component fitting.Type: GrantFiled: December 19, 2001Date of Patent: May 9, 2006Assignee: Vogt Electronic AGInventors: Klaus Neumeier, Anton Duschl, Erwin Gaisbauer, Johann Winkler, Roman Schichl
-
Patent number: 6903648Abstract: An oscillating inductor has a symmetrical double-E core, which has two geometrically identical core windows, a cuboid center limb and two cuboid outer limbs. The double-E core is designed such that a longitudinal cross sectional area of the center limb is greater than 90 mm2, with a longitudinal cross section being regarded as a cross section which would separate the double-E core into two single E-cores, and the cross section being at right angles to the longitudinal cross section such that the double-E can be identified in the cross section, with the double-E core being located in a component volume of less than 26.5 mm×26.5 mm×15 mm (width×depth×height).Type: GrantFiled: January 9, 2004Date of Patent: June 7, 2005Assignee: Vogt Electronic AGInventors: Michael Baumann, Johann Winkler
-
Publication number: 20040140775Abstract: An oscillating inductor has a symmetrical double-E core, which has two geometrically identical core windows, a cuboid center limb and two cuboid outer limbs. The double-E core is designed such that a longitudinal cross sectional area of the center limb is greater than 90 mm2, with a longitudinal cross section being regarded as a cross section which would separate the double-E core into two single E-cores, and the cross section being at right angles to the longitudinal cross section such that the double-E can be identified in the cross section, with the double-E core being located in a component volume of less than 26.5 mm×26.5 mm×15 mm (width×depth×height).Type: ApplicationFiled: January 9, 2004Publication date: July 22, 2004Applicant: Vogt Electronic AGInventors: Michael Baumann, Johann Winkler
-
Patent number: 6731076Abstract: A gas discharge lamp base (1) with a starting device has a carrier part (16) for electronic components (23 through 30) of the starting device. The carrier part (16) has a top side and a bottom side. Only high voltage-carrying components (23 through 26) of the starting device are arranged on the one side of the carrier part (16), and only low voltage-carrying components (27 through 30) of the starting device are arranged on the other side (low voltage side) of the carrier part (16).Type: GrantFiled: February 5, 2001Date of Patent: May 4, 2004Assignees: Vogt electronic AG, Patent-Treuhand-Gesellschaft fuer elektrische GluehlampenInventors: Karl Gerhard, Erwin Gaisbauer, Anton Duschl, Johann Winkler, Christian Wittig, Guenther Hirschmann, Peter Helbig, Hartmut Froescher, Markus Siegner, Franz Sagberger, Guenter Schinkinger
-
Publication number: 20040066150Abstract: A description is given of a gas-discharge lamp base (11) with a housing comprising an upper part (10) and a cover (40), a support (16) accommodated in the housing for receiving the components, with a transformer, with inductances connected in series with the lamp (1) and a capacitance connected in parallel with the lamp (1), the transformer comprising a bar transformer (23). This construction permits particularly efficient production, because the support can be constructed as a simple leadframe which permits automatic component fitting.Type: ApplicationFiled: November 12, 2003Publication date: April 8, 2004Inventors: Klaus Neumeier, Anton Duschl, Erwin Gaisbauer, Johann Winkler, Roman Schichl
-
Patent number: 6715535Abstract: A method of casting has a mold assembled on a base plate. The finished mold is rotated by approximately 180° around a horizontal rotational axis. A casting container with an upwardly positioned aperture end, removed from the mold, is filled with melt for one casting operation. The casting container is sealingly coupled by the aperture end to the ingate end of the mold. The mold, together with its contacting casting container, is rotated by approximately 180° around a horizontal axis. Accordingly, the melt reaches the mold, and the casting container is removed from the coupled position away from the mold.Type: GrantFiled: April 16, 2001Date of Patent: April 6, 2004Assignee: VAW mandl & berger GmbHInventors: Friedhelm Kahn, Joachim Kahn, Gerhard Eisenberger, Horst Paul Grüness, Walter Hauder, Johann Winkler, Peter Stika, Johann Preisinger, Peter Jungbauer, Klaus Schröter, Rolf Gosch
-
Publication number: 20040048381Abstract: The invention provides a two component system for in vitro cloning of a heterologous polynucleotide into adenoviral DNA. The first component is an insert donor comprising a heterologous polynucleotide encoding a heterologous polypeptide. The second component is a vector donor comprising an adenovirus genome and an expression cassette. The insert donor and vector donor are adapted for site specific recombination using recombination sites from phage lambda for insertion of the heterologous polynucleotide into the expression cassette capable of forming an adenoviral expression clone in vitro in the presence of a suitable recombination mediator protein or proteins. The invention also provides a method of making recombinant adenovirus and use of the first and second components in such a method.Type: ApplicationFiled: May 8, 2003Publication date: March 11, 2004Inventors: Johann Winkler, Kenneth Robert Bundell
-
Publication number: 20020000304Abstract: A method of casting has a mold assembled on a base plate. The finished mold is rotated by approximately 180° around a horizontal rotational axis. A casting container with an upwardly positioned aperture end, removed from the mold, is filled with melt for one casting operation. The casting container is sealingly coupled by the aperture end to the ingate end of the mold. The mold, together with its contacting casting container, is rotated by approximately 180° around a horizontal axis. Accordingly, the melt reaches the mold, and the casting container is removed from the coupled position away from the mold.Type: ApplicationFiled: April 16, 2001Publication date: January 3, 2002Inventors: Friedhelm Kahn, Joachim Kahn, Gerhard Eisenberger, Horst Paul Gruness, Walter Hauder, Johann Winkler, Peter Stika, Johann Preisinger, Peter Jungbauer, Klaus Schroter, Rolf Gosch