Patents by Inventor Johannes A. M. van der Heijden
Johannes A. M. van der Heijden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7605162Abstract: The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D2 receptor and/or the serotonin reuptake site, and the ability to treat conditions related to disturbances in the dopaminergic and/or the serotonergic systems such as anxiety disorders, depression, Parkinson's disease, and schizophrenia. The invention relates to a group of novel phenylpiperazine derivatives of the formula (I): wherein: X is a group of formula 1, 2, 3, 4, 5, 6, or 7 as defined in the text, m has the value 2 to 6; n has the value 0-2; R5 and R6 are independently H or alkyl (1-3C); or R5+R6 represent a group —(CH2)—p wherein p has the value 3-5, and R7 is alkyl (1-3C), alkoxy (1-3C), halogen or cyano; or R6+R7 (R7 at position 7 of the indole group) represent a group —(CH2)q wherein q has the value 2-4, and salts thereof.Type: GrantFiled: October 27, 2008Date of Patent: October 20, 2009Assignee: Solvay PharmaceuticalsInventors: Roelof Van Hes, Johannes A. M. Van der Heijden, Cornelis G. Kruse, Jacobus Tipker, Martinus T. M. Tulp, Gerben M. Visser, Bernard J. Van Vliet
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Publication number: 20090143406Abstract: The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D2 receptor and/or the serotonin reuptake site, and the ability to treat conditions related to disturbances in the dopaminergic and/or the serotonergic systems such as anxiety disorders, depression, Parkinson's disease, and schizophrenia. The invention relates to a group of novel phenylpiperazine derivatives of the formula (I): wherein: X is a group of formula 1, 2, 3, 4, 5, 6, or 7 as defined in the text, m has the value 2 to 6; n has the value 0-2; R5 and R6 are independently H or alkyl (1-3C); or R5+R6 represent a group —(CH2)—p wherein p has the value 3-5, and R7 is alkyl (1-3C), alkoxy (1-3C), halogen or cyano; or R6+R7 (R7 at position 7 of the indole group) represent a group —(CH2)q wherein q has the value 2-4, and salts thereof.Type: ApplicationFiled: October 27, 2008Publication date: June 4, 2009Inventors: Roelof Van Hes, Johannes A. M. Van der Heijden, Cornelis G. Kruse, Jacobus Tipker, Martinus T.M Tulp, Gerben M. Visser, Bernard J. Van Vliet
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Patent number: 7456182Abstract: The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D2 receptor and/or the serotonin reuptake site, and the ability to treat conditions related to disturbances in the dopaminergic and/or the serotonergic systems such as anxiety disorders, depression, Parkinson's disease, and schizophrenia. The invention relates to a group of novel phenylpiperazine derivatives of the formula (I): wherein: X is a group of formula 1, 2, 3, 4, 5, 6, or 7 as defined in the text, m has the value 2 to 6; n has the value 0-2; R5 and R6 are independently H or alkyl (1-3C); or R5+R6 represent a group —(CH2)—p wherein p has the value 3-5, and R7 is alkyl (1-3C), alkoxy (1-3C), halogen or cyano; or R6+R7 (R7 at position 7 of the indole group) represent a group —(CH2)q wherein q has the value 2-4, and salts thereof.Type: GrantFiled: June 12, 2006Date of Patent: November 25, 2008Assignee: Solvay Pharmaceuticals, Inc.Inventors: Roelof Van Hes, Johannes A. M. Van der Heijden, Cornelis G. Kruse, Jacobus Tipker, Martinus T. M. Tulp, Gerben M. Visser, Bernard J. Van Vliet
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Patent number: 7297699Abstract: The invention relates to a group of novel piperazine and piperidine derivatives of the formula wherein Y is hydrogen, halogen, alkyl (1-3C), or CN, CF3, OCF3, SCF3, alkoxy(1-3C), amino or mono- or dialkyl(1-3C) substituted amino or hydroxy, X is O, S, SO or SO2, —Z represents —C, ?C or —N, R1 and R2 independently represent hydrogen or alkyl (1-3C), Q is benzyl or 2-, 3- or 4-pyridylmethyl, wich groups may be substited with one or more more substituents from the group halogen, nitro, cyano, amino, mono- or di (1-3C)alkylamino, (1-3C) alkoxy, CF3, OCF3, SCF3, (1-4C)-alkyl, (1-3C)alkylsulfonyl or hydroxy, and salts and prodrugs thereof.Type: GrantFiled: May 16, 2005Date of Patent: November 20, 2007Assignee: Solvay Pharmaceuticals, Inc.Inventors: Roelof W. Feenstra, Johannes A. M. van der Heijden, Cornelis G. Kruse, Stephen K. Long, Gustaaf J. M. van Scharrenburg
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Patent number: 7067513Abstract: The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D2 receptor and/or the serotonin reuptake site, and the ability to treat conditions related to disturbances in the dopaminergic and/or the serotonergic systems such as aggression, anxiety disorders, autism, vertigo, depression, disturbances of cognition, disturbances of memory, Parkinson's disease, schizophrenia, and psychotic disorders. The invention relates to a group of novel phenylpiperazine derivatives of the formula (I): wherein: X is a group of formula 1, 2, 3, 4, 5, 6, or 7 as defined in the text, m has the value 2 to 6; n has the value 0–2; R5 and R6 are independently H or alkyl (1–3C); or R5+R6 represent a group —(CH2)—p wherein p has the value 3–5, and R7 is alkyl (1–3C), alkoxy (1–3C), halogen or cyano; or R6+R7 (R7 at position 7 of the indole group) represent a group —(CH2)q wherein q has the value 2–4, and salts thereof.Type: GrantFiled: August 22, 2000Date of Patent: June 27, 2006Assignee: Solvay Pharmaceuticals B.V.Inventors: Roelof Van Hes, Johannes A. M. Van der Heijden, Cornelis G Kruse, Jacobus Tipker, Martinus T. M Tulp, Gerben M Visser, Bernard J Van Vliet
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Patent number: 6911448Abstract: The invention relates to a group of novel piperazine and piperidine derivatives of the formula wherein Y is hydrogen, halogen, alkyl (1-3C), or CN, CF3, OCF3, SCF3, alkoxy(1-3C), amino or mono- or dialkyl(1-3C) substituted amino or hydroxy, X is O, S, SO or SO2, ---Z represents —C, ?C or —N, R1 and R2 independently represent hydrogen or alkyl (1-3C), Q is benzyl or 2-, 3- or 4-pyridylmethyl, wich groups may be substited with one or more more substituents from the group halogen, nitro, cyano, amino, mono- or di (1-3C)alkylamino, (1-3C) alkoxy, CF3, OCF3, SCF3, (1-4C)-alkyl, (1-3C)alkylsulfonyl or hydroxy, and salts and prodrugs thereof.Type: GrantFiled: May 10, 2001Date of Patent: June 28, 2005Assignee: Solvay Pharmaceuticals B.V.Inventors: Roelof W. Feenstra, Johannes A. M. van der Heijden, Cornelis G. Kruse, Stephen K. Long, Gustaaf J. M. van Scharrenburg
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Patent number: 6780864Abstract: The invention relates to a group of novel piperazine and piperidine derivatives of formula (I), wherein: S1 is hydrogen, halogen, alkyl (1-3C), CN, CF3, OCF3, SCF3, alkoxy (1-3C), amino or mono- or dialkyl (1-3C) substituted amino, or hydroxy; X represents NR3, S, CH2, O, SO or SO2, wherein R3 is H or alkyl (1-3C); . . . Z represents ═C or —N; —R1 independently represent H or alkyl (1-3C), or R1 and R2 together can form a bridge 2 or 3 C-atoms; R4 is hydrogen or alkyl (1-3C); Q is methyl, ethyl, ethyl substituted with one or more fluorine atoms, cyclopropyl—methyl, optionally substituted with one or more fluorine atoms, and salts and prodrugs thereof. It has been found that these compounds have both partial dopamine D2-receptor agonism and partial serotonin 5-HT1A-receptor agonism mediated activities.Type: GrantFiled: August 14, 2001Date of Patent: August 24, 2004Assignee: DUPHAR International Research BVInventors: Roelof Feenstra, Johannes A. M. Van Der Heijden, Cornelis G. Kruse, Stephen K. Long, Johannes Mos, Gerben M. Visser, Gustaaf J. M. Van Scharrenburg, Gerrit P. Toorop
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Publication number: 20030186838Abstract: The invention relates to the use of compounds having combined sopamine D2 agonistic activity, 5-HT1A agonistic activity and a adrenoceptor agonistic activity for the treatment of CNS disorders such as Parkinson's disease.Type: ApplicationFiled: November 12, 2002Publication date: October 2, 2003Inventors: Roelof W. Feenstra, Johannes A.M. van der Heijden, Stephen K. Long, Gustaaf J.M. van Scharrenburg
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Publication number: 20030119849Abstract: The invention relates to a group of novel piperazine and piperidine derivatives of the formula wherein Y is hydrogen, halogen, alkyl (1-3C), or CN, CF3, OCF3, SCF3, alkoxy(1-3C), amino or mono- or dialkyl(1-3C) substituted amino or hydroxy, X is O, S, SO or SO2, -Z represents —C, ═C or —N, R1 and R2 independently represent hydrogen or alkyl (1-3C), Q is benzyl or 2-, 3- or 4-pyridylmethyl, wich groups may be substited with one or more more substituents from the group halogen, nitro, cyano, amino, mono- or di (1-3C)alkylamino, (1-3C) alkoxy, CF3, OCF3, SCF3, (1-4C)-alkyl, (1-3C)alkylsulfonyl or hydroxy,and salts and prodrugs thereof. It has been found that these compounds have interesting pharmacological properties due to a combination of (partial) agonism towards the members of the dopamine D2-receptor subfamily and affinity for relevant serotonin and/or noradrenergic receptors.Type: ApplicationFiled: October 15, 2002Publication date: June 26, 2003Inventors: Roelof W. Feenstra, Johannes A.M. van der Heijden, Cornelis G. Kruse, Stephen K. Long, Gustaaf J.M. van Scharrenburg
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Patent number: 6391896Abstract: The invention is related to the following compounds: wherein all variables are as defined in the specification. The compounds are useful for treating psychotic disorders.Type: GrantFiled: July 3, 2001Date of Patent: May 21, 2002Assignee: Duphar International Research BVInventors: Roelof Van Hes, Johannes A. M. Van Der Heijden, Cornelis G. Kruse, Jacobus Tipker, Martinus T. M. Tulp, Gerben M. Visser, Bernard J. Van Vliet
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Patent number: 5001387Abstract: The electric lamp has a lamp vessel (1) which is fixed by means of cement (6) in a lamp cap (3) of synthetic material. A metal ring (7) in contact with the cement (6) is present in the lamp cap (3), as a result of which the cement (6) can be secured by inductive heating of the metal ring (7). The lamp cap (3) has ribs (10,11) on the inside surface of the lamp cap (3), by which the metal ring (7) is radially and axially separated from the lamp cap (3).Type: GrantFiled: September 28, 1987Date of Patent: March 19, 1991Assignee: U.S. Philips CorporationInventor: Johannes M. A. van der Heijden
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Patent number: 4920297Abstract: Electric lamp having a lamp envelope and a synthetic material lamp bowl which is secured to the lamp envelope and is provided with a lamp cap (7). The lamp envelope, on its side facing the lamp bowl, is provided with a plurality of projecting plate-shaped members extending substantially parallel to the lamp axis (A-B). The inner wall of the lamp bowl has ribs which also extend substantially parallel to the lamp axis. The plate shaped members engage the ribs to secure the lamp envelope to the lamp bowl.Type: GrantFiled: December 21, 1988Date of Patent: April 24, 1990Assignee: U.S. Philips CorporationInventors: Johannes M. A. van der Heijden, Pierre L. L. M. Derks, Cornelis Penning
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Patent number: 4404491Abstract: In some types of electric incandescent lamps a cylindrical contact cap is connected to the part of the current supply conductor projecting beyond the pinch seal of the lamp envelope, which cap is mounted in an insulator sleeve. In known lamps the ceramic insulator sleeve 9 is secured on the pinch seal by means of cement.In lamps according to the invention, the insulator sleeve is coupled to the contact cap by means of a metal spring.Type: GrantFiled: October 27, 1980Date of Patent: September 13, 1983Assignee: U.S. Philips CorporationInventors: Gustaaf F. R. Siaens, Johannes M. A. Van der Heijden