Patents by Inventor Johannes Graeff

Johannes Graeff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF DIAGNOSIS ALZHEIMER'S DISEASE
    Publication number: 20190233894
    Abstract: A method for the diagnosis or prognosis of Alzheimer's disease (AD), includes the steps of placing a sample isolated from a person suspected of having AD onto a substrate labeling the sample to identify at least one epigenetic marker and/or genetic variation and determining a state of AD. One of the epigenetic markers is PM20D1 promoter DNA methylation and/or one of the genetic variation is in at least one of PM20D1 mQTL-associated SNPs. PM20D1 is used as a therapeutic target and viral vectors encoding PM20D1 are used in the therapy of AD. Moreover, a kit for diagnosing AD includes reagents for detecting the SNPs rs708727, rs947211, rs708730, rs708724 or rs823130.
    Type: Application
    Filed: July 14, 2017
    Publication date: August 1, 2019
    Inventors: Jose Vicente SACHEZ MUT, Johannes GRÄFF, Holger HEYN, Manuel ESTELLER BADOSA
  • THE USE OF GENE EXPRESSION PROFILING AS A BIOMARKER FOR ASSESSING THE EFFICACY OF HDAC INHIBITOR TREATMENT IN NEURODEGENERATIVE CONDITIONS
    Publication number: 20150219673
    Abstract: The present invention relates to methods, arrays, and kits for identifying Alzheimer's disease phenotype and for assessing the efficacy of putative AD therapies. In some aspects provided, is a method of identifying the presence of an Alzheimer's disease phenotype in a subject comprising: performing an assay to measure an expression pattern of at least one Alzheimer's associated gene.
    Type: Application
    Filed: September 4, 2013
    Publication date: August 6, 2015
    Inventors: Li-Huei Tsai, Johannes Graeff, Nadine F. Joseph
  • Use of CI-994 and dinaline for the treatment of memory/cognition and anxiety disorders
    Patent number: 8841346
    Abstract: The invention relates to methods and compositions for promoting cognitive function and/or treating cognitive function disorders and impairments. In particular the methods are accomplished by administering to a subject CI-994 or dinaline or a pharmaceutically acceptable salt, ester, prodrug or metabolite thereof.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: September 23, 2014
    Assignees: Massachusetts Institute of Technology, The Broad Institute, Inc., The General Hospital Corporation
    Inventors: Li-Huei Tsai, Ji-Song Guan, Stephen J. Haggarty, Edward Holson, Florence Wagner, Johannes Graeff
  • Use of CI-994 and dinaline for the treatment of memory/cognition and anxiety disorders
    Patent number: 8563615
    Abstract: The invention relates to methods and compositions for promoting cognitive function and/or treating cognitive function disorders and impairments. In particular the methods are accomplished by administering to a subject CI-994 or dinaline or a pharmaceutically acceptable salt, ester, prodrug or metabolite thereof.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: October 22, 2013
    Assignees: Massachusetts Institute of Technology, The Broad Institute, Inc., Massachusetts General Hospital
    Inventors: Li-Huei Tsai, Ji-Song Guan, Stephen J. Haggarty, Edward Holson, Florence Wagner, Johannes Graeff
  • USE OF CI-994 AND DINALINE FOR THE TREATMENT OF MEMORY/COGNITION AND ANXIETY DISORDERS
    Publication number: 20120322879
    Abstract: The invention relates to methods and compositions for promoting cognitive function and/or treating cognitive function disorders and impairments. In particular the methods are accomplished by administering to a subject CI-994 or dinaline or a pharmaceutically acceptable salt, ester, prodrug or metabolite thereof.
    Type: Application
    Filed: August 27, 2012
    Publication date: December 20, 2012
    Inventors: Li-Huei Tsai, Ji-Song Guan, Stephen J. Haggarty, Edward Holson, Florence Wagner, Johannes Graeff
  • USE OF CI-994 AND DINALINE FOR THE TREATMENT OF MEMORY/COGNITION AND ANXIETY DISORDERS
    Publication number: 20110224303
    Abstract: The invention relates to methods and compositions for promoting cognitive function and/or treating cognitive function disorders and impairments. In particular the methods are accomplished by administering to a subject CI-994 or dinaline or a pharmaceutically acceptable salt, ester, prodrug or metabolite thereof.
    Type: Application
    Filed: November 1, 2010
    Publication date: September 15, 2011
    Inventors: Li-Huei Tsai, Ji-Song Guan, Stephen J. Haggarty, Edward Holson, Florence Wagner, Johannes Graeff