Patents by Inventor Johannes Hübner

Johannes Hübner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polypeptides derived from and their use for vaccination and the generation of therapeutic antibodies
    Patent number: 11278609
    Abstract: Medicament for the treatment or the prevention of a bacterial infection, characterized in that it contains at least one polypeptide selected from the group of SEQ ID NO: 1 to SEQ ID NO: 9, and contiguous fragments thereof, wherein said at least one polypeptide or contiguous fragment thereof induces opsonic antibodies in a patient in need thereof. The polypeptides or the contiguous fragments thereof according to the present invention can be used for the preparation of a vaccine against an infection against Enterococcus.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: March 22, 2022
    Assignees: KLINIKUM DER UNIVERSITÄT MÜNCHEN, UNIVERSITE DE CAEN BASSE-NORMANDIE
    Inventors: Johannes Hübner, Axel Hartke, Luis Felipe Romero Saavedra
  • and/or antigen
    Patent number: 11267841
    Abstract: The present invention generally relates to the field of detecting and preventing infectious diseases caused by Enterococcus faecalis and/or Enterococcus faecium.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: March 8, 2022
    Assignee: KLINIKUM DER UNIVERSITÄT MÜNCHEN
    Inventors: Johannes Hübner, Otto Holst, Christian Theilacker, Zbigniew Kaczynski
  • ENTEROCOCCUS FAECALIS AND/OR ENTEROCOCCUS FAECIUM ANTIGEN
    Publication number: 20200048296
    Abstract: The present invention generally relates to the field of detecting and preventing infectious diseases caused by Enterococcus faecalis and/or Enterococcus faecium.
    Type: Application
    Filed: October 7, 2019
    Publication date: February 13, 2020
    Inventors: JOHANNES HÜBNER, OTTO HOLST, CHRISTIAN THEILACKER, ZBIGNIEW KACZYNSKI
  • Opsonic and protective monoclonal antibodies against gram-positive pathogens
    Patent number: 10100103
    Abstract: The present invention in the fields of immunology and infectious diseases relates to opsonic and protective antibodies that are specific for Gram-positive bacteria, particularly to carbohydrate structures exposed on the surface of the bacteria. The invention includes monoclonal and chimeric antibodies, as well as fragments, regions and derivatives thereof. This invention also relates to the epitope to which the antibodies of the invention bind as well as the sequences, fragments, and regions of the epitopes. Both the antibodies and peptides that encompass the epitope, and regions and fragments thereof, may be used for diagnostic, prophylactic and therapeutic applications.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: October 16, 2018
    Assignee: ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG
    Inventors: Johannes Hübner, Friederike Rossmann, Andrea Kropec Hübner
  • ENTEROCOCCUS FAECALIS AND/OR ENTEROCOCCUS FAECIUM ANTIGEN
    Publication number: 20180009834
    Abstract: The present invention generally relates to the field of detecting and preventing infectious diseases caused by Enterococcus faecalis and/or Enterococcus faecium.
    Type: Application
    Filed: August 31, 2017
    Publication date: January 11, 2018
    Inventors: Johannes HÜBNER, Otto HOLST, Christian THEILACKER, Zbigniew KACZYNSKI
  • and/or antigen
    Patent number: 9796744
    Abstract: The present invention generally relates to the field of detecting and preventing infectious diseases caused by Enterococcus faecalis and/or Enterococcus faecium.
    Type: Grant
    Filed: November 13, 2007
    Date of Patent: October 24, 2017
    Assignee: UNIVERSITÄTSKLINIKUM FREIBURG
    Inventors: Johannes Hübner, Otto Holst, Christian Theilacker, Zbigniew Kaczynski
  • Cell wall polymers of and uses thereof
    Patent number: 9750796
    Abstract: The present invention relates to enterococcal cell wall polymers and their uses in the prevention and therapy of bacterial infection.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: September 5, 2017
    Assignees: UNIVERSITAETSKLINKUM FREIBURG, FORSCHUNGSZENTRUM BORSTEL
    Inventors: Johannes Huebner, Otto Holst, Christian Theilacker, Karolina Kruszynska, Stefan Geiss-Liebisch, Agnieszka Beczala
  • Polypeptides Derived from Enterococcus and Their Use for Vaccination and the Generation of Therapeutic Antibodies
    Publication number: 20170087239
    Abstract: Medicament for the treatment or the prevention of a bacterial infection, characterized in that it contains at least one polypeptide selected from the group of SEQ ID NO: 1 to SEQ ID NO: 9, and contiguous fragments thereof, wherein said at least one polypeptide or contiguous fragment thereof induces opsonic antibodies in a patient in need thereof. The polypeptides or the contiguous fragments thereof according to the present invention can be used for the preparation of a vaccine against an infection against Enterococcus.
    Type: Application
    Filed: February 25, 2015
    Publication date: March 30, 2017
    Inventors: Johannes HÜBNER, Axel HARTKE, Felipe ROMERO
  • Opsonic and Protective Monoclonal Antibodies Against Gram-Positive Pathogens
    Publication number: 20160318997
    Abstract: The present invention in the fields of immunology and infectious diseases relates to opsonic and protective antibodies that are specific for Gram-positive bacteria, particularly to carbohydrate structures exposed on the surface of the bacteria. The invention includes monoclonal and chimeric antibodies, as well as fragments, regions and derivatives thereof. This invention also relates to the epitope to which the antibodies of the invention bind as well as the sequences, fragments, and regions of the epitopes. Both the antibodies and peptides that encompass the epitope, and regions and fragments thereof, may be used for diagnostic, prophylactic and therapeutic applications.
    Type: Application
    Filed: November 17, 2014
    Publication date: November 3, 2016
    Inventors: Johannes HÜBNER, Friederike ROSSMANN, Andrea KROPEC HÜBNER
  • Synthetic LTA mimetics and use thereof as vaccine component for therapy and/or prophylaxis against gram-positive infections
    Patent number: 9290531
    Abstract: The present invention relates to synthetic lipoteicoic acid (LTA) mimetics which are useful as vaccine components for therapy and/or prophylaxis of bacterial infection.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: March 22, 2016
    Assignee: UNIVERSITÄTSKLINIKUM FREIBURG
    Inventors: Johannes Huebner, Andrea Huebner-Kropec, Jeroen Dirk Cornelis Codée, Gijsbert Arie Van Der Marel, Wouter Frederick Johan Hogendorf
  • Rhamno-polysaccharide from clonal complex 17 and uses thereof
    Patent number: 9255157
    Abstract: The present invention relates to a rhamno-polysaccharide antigen from Enterococcus faecium clonal complex which is useful as a vaccine component for therapy and/or prophylaxis of bacterial infection.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: February 9, 2016
    Assignees: Universitaetsklinikum Freiburg, Forschungszentrum Borstel
    Inventors: Johannes Hübner, Christian Theilacker, Zbigniew Kaczynski, Otto Holst
  • NOVEL CELL WALL POLYMERS OF ENTEROCOCCUS FAECALIS AND USES THEREOF
    Publication number: 20150139998
    Abstract: The present invention relates to enterococcal cell wall polymers and their uses in the prevention and therapy of bacterial infection.
    Type: Application
    Filed: March 4, 2013
    Publication date: May 21, 2015
    Inventors: Johannes Huebner, Otto Holst, Christian Theilacker, Karolina Kruszynska, Stefan Geiss-Liebisch, Agnieszka Beczala
  • Cell wall components of enterococci and uses thereof
    Patent number: 9005622
    Abstract: The present invention relates to enterococcal cell wall components and their uses in the prevention and therapy of bacterial infection.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: April 14, 2015
    Assignees: Forschungszentrum Borstel, Universitätsklinikum Freiburg
    Inventors: Johannes Hübner, Christian Theilacker, Otto Holst, Zbigniew Kaczynski
  • Rhamno-Polysaccharide From Enterococcus Faecium Clonal Complex 17 and Uses Thereof
    Publication number: 20140161792
    Abstract: The present invention relates to a rhamno-polysaccharide antigen from Enterococcus faecium clonal complex which is useful as a vaccine component for therapy and/or prophylaxis of bacterial infection.
    Type: Application
    Filed: May 25, 2012
    Publication date: June 12, 2014
    Applicants: FORSCHUNGSZENTRUM BORSTEL, UNIVERSIT TSKLINIKUM FREIBURG
    Inventors: Johannes Hübner, Christian Theilacker, Zbignew Kacynski, Otto Holst
  • Polypeptide derived from and its use for vaccination
    Patent number: 8741302
    Abstract: A medicament for the treatment or the prevention of a bacterial infection is disclosed which contains a polypeptide having a contiguous sequence of at least six amino acids of SEQ ID NO:1. Said polypeptide can be used for the preparation of a vaccine against an Enterococcus infection.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: June 3, 2014
    Assignee: Universitatsklinikum Freiburg
    Inventors: Johannes Huebner, Andrea Kropec-Huebner, Irina Sava
  • SYNTHETIC LTA MIMETICS AND USE THEREOF AS VACCINE COMPONENT FOR THERAPY AND/OR PROPHYLAXIS AGAINST GRAM-POSITIVE INFECTIONS
    Publication number: 20140050741
    Abstract: The present invention relates to synthetic lipoteicoic acid (LTA) mimetics which are useful as vaccine components for therapy and/or prophylaxis of bacterial infection.
    Type: Application
    Filed: February 17, 2012
    Publication date: February 20, 2014
    Applicants: UNIVERSITEIT LEIDEN, UNIVERSITÄTSKLINIKUM FREIBURG
    Inventors: Johannes Huebner, Andrea Huebner-Kropec, Jeroen Dirk Cornelis Codée, Gijsbert Arie Van Der Marel, Wouter Frederick Johan Hogendorf
  • NOVEL ANTIGEN OF ENTEROCOCCAL PATHOGENS AND USE THEROF AS VACCINE COMPONENT FOR THERAPY AND/OR PROPHYLAXIS
    Publication number: 20130309264
    Abstract: The present invention relates to antigens, more particularly protein antigens of enterococcal pathogens which are useful as vaccine components for therapy and/or prophylaxis.
    Type: Application
    Filed: November 3, 2011
    Publication date: November 21, 2013
    Applicant: UNIVERSITÄTSKLINIKUM FREIBURG
    Inventors: Johannes Hübner, Elisabeth Grohmann, Andrea Kropec-Hübner
  • Novel Cell Wall Components of Enterococci and Uses Thereof
    Publication number: 20120282268
    Abstract: The present invention relates to enterococcal cell wall components and their uses in the prevention and therapy of bacterial infection.
    Type: Application
    Filed: January 19, 2010
    Publication date: November 8, 2012
    Inventors: Johannes Hübner, Christian Theilacker, Otto Holst, Zbigniew Kaczynski
  • Polypeptide Derived From Enterococcus And Its Use For Vaccination
    Publication number: 20120121638
    Abstract: A medicament for the treatment or the prevention of a bacterial infection is disclosed which contains a polypeptide having a contiguous sequence of at least six amino acids of SEQ ID NO:1. Said polypeptide can be used for the preparation of a vaccine against an Enterococcus infection.
    Type: Application
    Filed: April 26, 2010
    Publication date: May 17, 2012
    Inventors: Johannes Huebner, Andrea Kropec-Huener, Irina Sava
  • Method and device for adapting a radio network model to the conditions of a real radio network
    Patent number: 7877095
    Abstract: A method of adapting a radio network model to conditions of a real radio network consists of the following steps: defining different measuring positions; carrying out measurements of variables at the different measuring positions, thereby generating measured data; providing position-dependent modelling values, using the measured data for the modelling values from the real radio network obtained at the measuring positions; setting a fine grid in a radio cell, defining small area portions, wherein one or more of the modelling values is attributed to each area portion by the radio network model. Mathematical operations are then established for modifying the modelling values of all area portions of the fine grid by adapting the modelling values to the measured data. In this manner, the mathematical operations are for each area portion and directly dependent on the measured data and the position of the respective area portions.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: January 25, 2011
    Assignee: Actix GmbH
    Inventors: Johannes Hübner, Dietrich Hunold