Abstract: The presently claimed invention is directed to a copolymer obtained by reacting at least one isocyanate (A) comprising at least one allophanate group and at least one active double bond with at least one isocyanate reactive component (B) to form an intermediate product (C); and reacting the intermediate product (C) with at least one active double bond reactive component (D) to obtain the copolymer which can be used as dispersant. The at least one isocyanate reactive component (B) is selected from the group consisting of monofunctional polyether amine (B1), monofunctional polyether alcohol (B2), C6-C30 monofunctional alcohol (B3) and monofunctional polyester alcohol (B4).

Abstract: The presently claimed invention relates to an amine-modified polymer and method for preparation thereof. The presently claimed invention is also directed to the use of the polymer as dispersant in ink and coating compositions. Polyacrylate polymer is obtained by controlled free radical polymerization of a mixture comprising at least one acrylate monomer. The post-modification of polyacrylate polymers yields amine-modified polymers that provide improved viscosity parameters, without sacrificing the advantages of a well-defined polymer structure.

Abstract: Provided herein are methods and compounds for targeted autophagy.

Abstract: The presently claimed invention relates to polyalkyleneimine-based polymers that are useful as dispersants and a process for the preparation thereof. The presently claimed invention is also directed to dispersants that are useful in solvent-based dispersion systems as well as in water-based dispersion systems.

Abstract: The presently claimed invention is directed to a copolymer obtained by reacting at least one isocyanate (A) comprising at least one allophanate group and at least one active double bond with at least one isocyanate reactive component (B) to form an intermediate product (C); and reacting the intermediate product (C) with at least one active double bond reactive component (D) to obtain the copolymer which can be used as dispersant. The at least one isocyanate reactive component (B) is selected from the group consisting of monofunctional polyether amine (B1), monofunctional polyether alcohol (B2), C6-C30 monofunctional alcohol (B3) and monofunctional polyester alcohol (B4).

Abstract: The presently claimed invention relates to a dispersant containing oxyalkylenecarbonyl units and a process for its preparation. The presently claimed invention is also directed to the use of the dispersant in a coating composition or an ink composition.

Abstract: Techniques for characterizing protein candidate sites are provided. Experimental data comprising spectral data from an experimental data source is received. Based on the experimental data, a data set comprising a set of protein candidate sites within one or more proteins is created. For each protein candidate site of the set of protein candidate sites, a feature set characterizing the respective protein candidate site is generated. A characterization of the amenability for drug-discovery for one or more of the protein candidate sites is generated by applying a classifier to the respective feature set for the protein candidate site.

Abstract: Techniques for characterizing protein candidate sites are provided. Experimental data comprising spectral data from an experimental data source is received. Based on the experimental data, a data set comprising a set of protein candidate sites within one or more proteins is created. For each protein candidate site of the set of protein candidate sites, a feature set characterizing the respective protein candidate site is generated. A characterization of the amenability for drug-discovery for one or more of the protein candidate sites is generated by applying a classifier to the respective feature set for the protein candidate site.

Abstract: A method of unloading an object from a support table, the object clamped to the support table during an exposure process by: applying a first pressure to a central region of the support table under a central portion of the object; and applying a second pressure to a peripheral region of the support table under a peripheral portion of the object, wherein during clamping the first pressure and the second pressure are controlled such that liquid is retained between the object and a seal member that is positioned radially between the central region and the peripheral region at an upper surface of the support table and protrudes towards the object, the method including: increasing the first pressure towards ambient pressure; removing at least some of the liquid retained between the object and the seal member by decreasing the second pressure; and increasing the second pressure towards the ambient pressure.

Abstract: There are provided compounds of the formula wherein R1 and R2 are as described herein. The compounds are useful as anticancer agents.

Abstract: There are provided compounds of the formula wherein R1 and R2 are as described herein. The compounds are useful as anticancer agents.

Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R, R2, and R3 are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

Abstract: There are provided compounds of the formula (I) wherein Q, R1 and R2 are defined herein. The compounds have activity as anticancer agents.

Abstract: There are provided compounds of the formula or a pharmaceutically acceptable salt thereof wherein X, M, Y, R1 and R2 are as defined herein. The compounds have activity as anticancer agents.

Abstract: There are provided compounds of the formula wherein R1 and R2 are as described herein. The compounds are useful as anticancer agents.

Abstract: There are provided compounds of the formula (I) wherein Q, R1 and R2 are defined herein. The compounds have activity as anticancer agents.

Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables n, p, q, Q, X, X? and Y are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q, R2, R3, and Y are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R1 and R2 are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R, R2, and R3 are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.