Patents by Inventor Johannes Petrus Maria Tommassen
Johannes Petrus Maria Tommassen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11291713Abstract: The current invention lies in the field of medicine and more specifically in the field of vaccinology. The current invention concerns a novel Bordetella LPS and a modified bacterium of the genus Bordetella comprising such modified LPS. The LPS of the invention has a reduced endotoxicity in comparison to an unmodified Bordetella LPS. The modified LPS of the invention is therefore particularly suitable for use in inducing or stimulating an immune response in a subject, wherein the immune response is induced or stimulated against a Bordetella infection. The modified Bordetella LPS of the invention is obtainable by introducing in a Bordetella cell the expression of a heterologous acyl transferase. In particular, the modified Bordetella cell of the invention has an increased expression of an heterologous LpxA, LpxL or LpxD acyl transferase.Type: GrantFiled: March 13, 2018Date of Patent: April 5, 2022Assignee: Intravacc B.V.Inventors: Peter André van der Ley, Jesús Andrés Arenas Busto, Elder Pupo Escalona, Johannes Petrus Maria Tommassen
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Publication number: 20200085933Abstract: The current invention lies in the field of medicine and more specifically in the field of vaccinology. The current invention concerns a novel Bordetella LPS and a modified bacterium of the genus Bordetella comprising such modified LPS. The LPS of the invention has a reduced endotoxicity in comparison to an unmodified Bordetella LPS. The modified LPS of the invention is therefore particularly suitable for use in inducing or stimulating an immune response in a subject, wherein the immune response is induced or stimulated against a Bordetella infection. The modified Bordetella LPS of the invention is obtainable by introducing in a Bordetella cell the expression of a heterologous acyl transferase. In particular, the modified Bordetella cell of the invention has an increased expression of an heterologous LpxA, LpxL or LpxD acyl transferase.Type: ApplicationFiled: March 13, 2018Publication date: March 19, 2020Applicant: De Staat der Nederlanden, vert. door de minister van VWS, Ministerie van Volksgezondheid, Welzijn enInventors: Peter André van der Ley, Jesús Andrés Arenas Busto, Elder Pupo Escalona, Johannes Petrus Maria Tommassen
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Publication number: 20190008943Abstract: Compositions and methods for the treatment or prevention of Gram-negative bacterial strain infection are provided herein. Methods for the manufacture of said compositions are also provided herein.Type: ApplicationFiled: June 18, 2018Publication date: January 10, 2019Inventors: Jan POOLMAN, Nathalie Isabelle DEVOS, Michiel STORK, Johannes Petrus Maria TOMMASSEN, Vincent WEYNANTS
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Publication number: 20170080075Abstract: Compositions and methods for the treatment or prevention of Gram-negative bacterial strain infection are provided herein. Methods for the manufacture of said compositions are also provided herein.Type: ApplicationFiled: April 28, 2016Publication date: March 23, 2017Inventors: Jan POOLMAN, Nathalie Isabelle DEVOS, Michiel STORK, Johannes Petrus Maria TOMMASSEN, Vincent WEYNANTS
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Publication number: 20160243211Abstract: The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bactericidal antibodies are generated against said antigen. It has been found for the first time that this antigen's expression is zinc regulated and therefore methods are provided to upregulated expression through removal of the zinc repression mechanism of the cell or promoter, or through removal of zinc from the culture medium.Type: ApplicationFiled: January 7, 2016Publication date: August 25, 2016Inventors: Martine Petronella Bos, Jan Poolman, Michiel Stork, Johannes Petrus Maria Tommassen, Vincent Weynants
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Patent number: 9365624Abstract: Compositions and methods for the treatment or prevention of Gram-negative bacterial strain infection are provided herein. Methods for the manufacture of said compositions are also provided herein.Type: GrantFiled: March 11, 2011Date of Patent: June 14, 2016Assignees: GlaxoSmithKline Biologicals, S.A., Utrecht UniversityInventors: Jan Poolman, Michiel Stork, Johannes Petrus Maria Tommassen, Nathalie Isabelle Devos, Vincent Weynants
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Patent number: 9296995Abstract: The invention relates to an improved vaccine against pertussis wherein mutants of Bordetella pertussis having a modified LPS molecule or the obtainable LPS molecules are used. These mutants or the obtainable LPS molecules may further be used as an adjuvant.Type: GrantFiled: March 25, 2008Date of Patent: March 29, 2016Assignee: DE STAAT DER NEDERLANDEN, VERT. DOOR DE MINISTER VAN VWSInventors: Jeroen Johannes Gerardus Geurtsen, Johannes Petrus Maria Tommassen, Peter André Van Der Ley
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Patent number: 9259461Abstract: The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bacterial antibodies are generated against said antigen. Methods are also provided to upregulate expression through removal of the zinc repression mechanism of the cell or promoter or through removal of zinc from the culture medium.Type: GrantFiled: March 6, 2009Date of Patent: February 16, 2016Assignee: GlaxoSmithKline Biologicals, S.A.Inventors: Martine Petronella Bos, Jan Poolman, Michiel Stork, Johannes Petrus Maria Tommassen, Vincent Weynants
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Publication number: 20130004510Abstract: Compositions and methods for the treatment or prevention of Gram-negative bacterial strain infection are provided herein. Methods for the manufacture of said compositions are also provided herein.Type: ApplicationFiled: March 11, 2011Publication date: January 3, 2013Inventors: Jan Poolman, Michiel Stork, Johannes Petrus Maria Tommassen, Nathalie Isabelle Devos, Vincent Weynants
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Patent number: 8163295Abstract: The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally down-regulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.Type: GrantFiled: August 17, 2011Date of Patent: April 24, 2012Assignees: GlaxoSmithKline Biologicals S.A., University of UtrechtInventors: Martine Petronella Bos, Jan Poolman, Boris Tefson, Johannes Petrus Maria Tommassen
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Publication number: 20120039942Abstract: The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally down-regulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.Type: ApplicationFiled: August 17, 2011Publication date: February 16, 2012Applicants: GLAXOSMITHKLINE BIOLOGICALS S.A.Inventors: Martine Petronella Bos, Jan Poolman, Boris Tefson, Johannes Petrus Maria Tommassen
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Patent number: 8048433Abstract: The current invention provides new Gram negative polypeptides exhibiting lipid A 3-O-deacylase activity and are capable of modifying and/or detoxifying gram negative LPS. The present invention also provides Gram negative bacteria, Gram negative bacterial lipopolysaccharides (LPS) and compositions comprising LPS, which are provided with or treated with a 3-O-deacylase activity according to the invention and which may be used for pharmaceutical and/or veterinary purposes, in particular for the preparation of whole cell or acellular vaccines against pathogenic Gram negatives such as Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.Type: GrantFiled: December 16, 2005Date of Patent: November 1, 2011Assignee: NVI Nederlands VaccininstituutInventors: Johannes Petrus Maria Tommassen, Peter André Van Der Ley, Jeroen Johannes Gerardus Geurtsen
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Patent number: 8029807Abstract: The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.Type: GrantFiled: November 3, 2009Date of Patent: October 4, 2011Assignees: GlaxoSmithKline Biologicals S.A., University of UtrechtInventors: Martine Petronella Bos, Jan Poolman, Boris Tefson, Johannes Petrus Maria Tommassen
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Publication number: 20110189215Abstract: The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bacterial antibodies are generated against said antigen. Methods are also provided to upregulate expression through removal of the zinc repression mechanism of the cell or promoter or through removal of zinc from the culture medium.Type: ApplicationFiled: March 6, 2009Publication date: August 4, 2011Inventors: Martine Petronella Bos, Jan Poolman, Michiel Stork, Johannes Petrus Maria Tommassen, Vincent Weynants
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Publication number: 20100291153Abstract: The invention relates to an improved vaccine against pertussis wherein mutants of Bordetella pertussis having a modified LPS molecule or the obtainable LPS molecules are used. These mutants or the obtainable LPS molecules may further be used as an adjuvant.Type: ApplicationFiled: March 25, 2008Publication date: November 18, 2010Applicant: De Staat der Nederlanden, vert. door de minister van VWSInventors: Jeroen Johannes Gerardus Geurtsen, Johannes Petrus Maria Tommassen, Peter André Van Der Ley
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Publication number: 20100291137Abstract: The present invention provides an isolated refolded NspA protein, and a method of preparing it.Type: ApplicationFiled: January 25, 2010Publication date: November 18, 2010Applicant: GLAXOSMITHKLINE BIOLOGICALS SAInventors: Ralph Biemans, Martine Bos, Philippe Denoel, Christiane Feron, Carine Goraj, Jan Poolman, Vincent Weynants, Johannes Petrus Maria Tommassen
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Publication number: 20100047287Abstract: The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally down-regulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.Type: ApplicationFiled: November 3, 2009Publication date: February 25, 2010Applicants: GLAXOSMITHKLINE S.A., UTRECHT UNIVERSITYInventors: Martine Petronella Bos, Jan Poolman, Boris Tefsen, Johannes Petrus Maria Tommassen
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Patent number: 7628995Abstract: The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.Type: GrantFiled: December 21, 2004Date of Patent: December 8, 2009Assignees: GlaxoSmithKline Biologicals S.A., University of UtrechtInventors: Martine Petronella Bos, Jan Poolman, Boris Tefsen, Johannes Petrus Maria Tommassen
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Publication number: 20080274145Abstract: The current invention provides new Gram negative polypeptides exhibiting lipid A 3-O-deacylase activity and are capable of modifying and/or detoxifying gram negative LPS. The present invention also provides Gram negative bacteria, Gram negative bacterial lipopolysaccharides (LPS) and compositions comprising LPS, which are provided with or treated with a 3-O-deacylase activity according to the invention and which may be used for pharmaceutical and/or veterinary purposes, in particular for the preparation of whole cell or acellular vaccines against pathogenic Gram negatives such as Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.Type: ApplicationFiled: December 16, 2005Publication date: November 6, 2008Inventors: Johannes Petrus Maria Tommassen, Peter Andre Van Der Ley, Jeroen Johannes Gerardus Geurtsen
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Patent number: 7105316Abstract: LbpB polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing LbpB polypeptides and polynucleotides in the design of protocols for the treatment of neisserial disease, among others, and diagnostic assays for such conditions.Type: GrantFiled: December 12, 2003Date of Patent: September 12, 2006Assignees: University of Utrecht, Technology FoundationInventors: Annika Margareta Pettersson-Fernholm, Johannes Petrus Maria Tommassen