Abstract: Systems, methods, and computer-readable media for deterministic dynamic shaping of traffic of a communication network are provided.

Abstract: This disclosure provides methods of reducing the risk of prostate cancer progression in patients with a histologically proven prostate cancer characterized as low or intermediate risk for which no other treatment for prostate cancer is indicated. The method comprises administering enzalutamide as a monotherapy in an amount and for a period of time clinically proven effective in reducing the risk of prostate cancer progression in a control population of patients under active surveillance and having histologically proven prostate cancers characterized as low or intermediate risk for which no other treatment for prostate cancer is indicated.

Abstract: An extrusion process for creating a roof ditch molding including forming a main body from a plastic material in a first stage extrusion, conveying the main body through a stacked array of die plates and into a first stage cooling tank, and communicating the main body from an outlet of the first stage cooling tank to a second stage extruder with crosshead die for applying a skim film bonding layer to the main body. Additional steps include applying a decorative layer over the skim bonding layer, communicating the main body to a third stage extruder with cross head die for applying wing portions in partially overlapping fashion along opposite side edges of the decorative layer and drawing the completed ditch molding through a second stage cooling tank prior to conducting one or more finishing operations.

Abstract: A system can migrate a source file system on a first computer to a destination file system on a second computer. The system can receive, at the second computer, a request from a client computer that indicates a file system operation, and that references a source file handle of the source file system that comprises an identifier of the source file system. The system can identify the destination file system based on the identifier of the source file system. The system can determine, from a source inode number of the source file handle, a source inode number segment. The system can determine, from the source inode number segment, a destination inode number segment. The system can determine, from the destination inode number segment, a destination inode number. The system can perform the file system operation on the destination file system using the destination inode number and the identifier of the destination file system.

Abstract: Per- and polyfluoroalkyl substances (PFAS) are destroyed by oxidation in supercritical conditions. PFAS in water can be concentrated and prepared for destruction in a pretreatment phase. Following annihilation of the PFAS in supercritical conditions to levels below 5 parts per trillion (ppt), the water effluent can be used to recover heat, returned to sub-critical conditions, and then released back into the environment.

Abstract: One embodiment provides an apparatus for displaying an image comprising: a first optical substrate comprising at least one waveguide layer configured to propagate light in a first direction, wherein the at least one waveguide layer of the first optical substrate comprises at least one grating lamina configured to extract the light from the first substrate along the first direction; and a second optical substrate comprising at least one waveguide layer configured to propagate the light in a second direction, wherein the at least one waveguide layer of the second optical substrate comprises at least one grating lamina configured to extract light from the second substrate along the second direction; wherein the at least one grating lamina of at least one of the first and second optical substrates comprises an SBG in a passive mode.

Abstract: Systems and methods are described herein for implementing a hybrid codec to compress and decompress image data using both lossy and lossless compression. In one example encoding process, it may be determined whether a first block of pixels of a frame of image data contains an edge. A type of compression by which to encode the first block may be selected based on that determination. The first block may be compressed using the selected type of compression. At least one second value associated with the first block of pixels may be set to indicate at least oof the compressed value or the type of compression used to compress the first block.

Abstract: The present invention relates to the use of a coating for improving glass strength and fracture toughness comprising the hydrolytic polycondensation product of one or more alkoxysilane(s) with one or more metal oxide(s) and/or metal alkoxide(s) in the presence of water and a catalyst.

Abstract: The invention relates to a new method of delivering an analyte to a transmembrane pore in a membrane. The method involves the use of microparticles.

Abstract: A delivery device for a collapsible prosthetic heart valve, the delivery device including an inner shaft, a distal sheath disposed about a portion of the inner shaft and forming a compartment with the inner shaft, the compartment being adapted to receive the prosthetic heart valve, the inner shaft and the distal sheath being movable relative to one another, and a handle including a frame having a longitudinal axis, a proximal end and a distal end, the handle further including a deployment actuator and a hub, each of the deployment actuator and the hub being independently capable of opening and closing the compartment, the hub further including a hub actuator coupled to the inner shaft.

Abstract: Devices, systems and techniques are used for cancer treatment. An example control device may be configured to be communicatively coupled to a radiation source of a radiotherapy device and a position sensor of the radiotherapy device. The example control device may be used to calculate, for a sliding window of a radiotherapy treatment, a positional error between: a measured target position signal determined from a series of images and sampled at the acquisition times of the images, and an estimated target position signal. The example control device may generate a computer-executable instruction configured to alter the radiotherapy treatment in response to the positional error violating a threshold.

Abstract: A rotary impact tool includes a motor housing, an electric motor supported in the motor housing, and a drive assembly for converting a continuous torque input from the motor to consecutive rotational impacts upon a workpiece. The drive assembly includes an anvil including an anvil lug and a hammer that is both rotationally and axially movable relative to the anvil. The hammer includes a hammer lug for imparting the consecutive rotational impacts upon the anvil lug. The rotary impact tool further comprises a printed circuit board assembly including a sensor that is configured to detect rotation of the anvil. The printed circuit board assembly is spaced from the anvil to define an axial gap therebetween.

Abstract: Aspects of the disclosure relate to oligonucleotides (e.g., RNAi oligonucleotides such as siRNAs) designed to target DUX4 RNAs and targeting complexes for delivering the oligonucleotides to cells (e.g., muscle cells) and uses thereof, particularly uses relating to treatment of disease (e.g., FSHD).

Abstract: A method for operating a collector assembly of a vehicle that receives electric current from a conductive pathway extending along a route being traversed by the vehicle to power loads of the vehicle. The method includes moving the collector assembly relative to the conductive pathway to examine one or more mechanical components of the collector assembly and sensing one or more electrical characteristics of the electric current conducted to the vehicle from the conductive pathway and through the collector assembly to test electrical components of the collector assembly or the vehicle. The method may implement responsive actions to control operation of the vehicle based on outcomes of one or more of an examination of the mechanical components or the test of the electrical components.

Abstract: Methods of enhancing efficiency of downstream chromatography steps for purification of proteins comprising: (a) passing a composition comprising a polypeptide of interest and various contaminants through an ion exchange membrane, wherein the polypeptide and the membrane have opposite charge, at operating conditions comprised of a buffer having a pH sufficiently distinct from the pi of the polypeptide to enhance the charge of the polypeptide and a low ionic strength effective to prevent the shielding of charges by buffer ions, which cause the membrane to bind the polypeptide and at least one contaminant, (b) overloading the ion exchange membrane such that at least one contaminant remains bound to the membrane while the polypeptide of interest is primarily in the effluent; (c) collecting the effluent from the ion exchange membrane comprising the polypeptide of interest; (d) subjecting the membrane effluent comprising the polypeptide of interest to a purification step of similar charge as the previous membrane,

Abstract: This invention relates to compounds that are agonists of the muscarinic M1 and/or M4 receptor and which are useful in the treatment of diseases mediated by the muscarinic M1 and M4 receptors. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula where X1; X2; R1 and R4 are as defined herein.

Abstract: Timing-based methods, systems, and computer readable mediums for a gated linear accelerator include synchronising a local clock of the linear accelerator with a clock of a patient monitoring system, determining latencies within one or more MR-gated radiotherapy processes and implementing latency based interlocks.

Abstract: Systems and methods for controlling operation of a vehicle system are provided. This vehicle system can be at least partially powered by electric current conducted to a collector device of the vehicle system from a conductive pathway extending along a route traveled by the vehicle system. A voltage level of the conductive pathway may be monitored, and a conduction impaired location of the conductive pathway may be identified based at least in part on the voltage level of the conductive pathway that is monitored. The collector device or a removal device may be controlled to remove a contaminant from the conductive pathway at the conduction impaired location, the vehicle system may be controlled to compensate for the conduction impaired location, and/or an off-board facility and/or another vehicle system may be notified of the conduction impaired location responsive to identifying the conduction impaired location.

Abstract: A method including detecting that a vehicle that may be propelled by an electric drive system having one or more motors disconnects or begins disconnecting from an off-board source of power while the one or more motors are being powered by the off-board source of power. The method may include supplanting a decreasing amount of a first electric energy supplied by the off-board source of power to the electric drive system with an amount of a second electric energy supplied by an onboard source of power to the electric drive system responsive to the detection of the disconnect from the off-board source of power.

Abstract: A device and method are presented. Largest and smallest successful values of a receive clock delay and a transmit clock delay are determined. A first set of parameters for an SPI coupled to a DDR flash memory are set, including the largest successful values of the transmit clock delay and the receive clock delay, and a first value of a RD cycle. A second set of parameters for the SPI are set, including the smallest successful value of the transmit clock delay and receive clock delay, and a second value of the RD cycle. One of the first and second sets of parameters is selected based on whether the first or second set of parameters results in successfully reading from the DDR flash memory over a larger range of operating temperatures. The SPI is programmed using the selected one of the first and second sets of parameters.