Patents by Inventor John A. Hucul

John A. Hucul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biosynthetic gene cluster for the production of a complex polyketide
    Patent number: 8030325
    Abstract: A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with 1 module, and a cytochrome P450 hydroxylase is described. Also provided are novel Streptomyces species and methods of modified Streptomyces species. Further described are novel compounds, 36-ketomeridamycin, C9-deoxomeridamycin, and C9-deoxoprolylmeridamcyin and uses thereof.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: October 4, 2011
    Assignee: Wyeth LLC
    Inventors: Min He, John Hucul, Bradley Arnold Haltli, Melissa M. Wagenaar, Edmund Idris Graziani, Mia Summers, Kerry Kulowski, Kevin Pong, Xidong Feng
  • Non-ribosomal peptide synthetases and associated biosynthetic genes
    Patent number: 7709620
    Abstract: The present invention describes the identification of novel non-ribosomal peptide synthetases and associated biosynthetic genes from Streptomyces hygroscopicus. The present invention further provides methods for generating novel compounds, such as antibiotics, from these synthetases and associated genes.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: May 4, 2010
    Assignee: Wyeth
    Inventors: John A. Hucul, Nathan Magarvey, Michael Greenstein
  • Biosynthetic Gene Cluster for the Production of a Complex Polyketide
    Publication number: 20090105294
    Abstract: A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with 1 module, and a cytochrome P450 hydroxylase is described. Also provided are novel Streptomyces species and methods of modified Streptomyces species. Further described are novel compounds, 36-ketomeridamycin, C9-deoxomeridamycin, and C9-deoxoprolylmeridamcyin and uses thereof.
    Type: Application
    Filed: July 25, 2008
    Publication date: April 23, 2009
    Applicant: Wyeth
    Inventors: Min He, John Hucul, Bradley Arnold Haltli, Melissa M. Wagenaar, Edmund Idris Graziani, Mia Summers, Kerry Kulowski, Kevin Pong, Xidong Feng
  • Non-ribosomal peptide synthetases and associated biosynthetic genes
    Patent number: 7341861
    Abstract: The present invention describes the identification of novel non-ribosomal peptide synthetases and associated biosynthetic genes from Streptomyces hygroscopicus. The present invention further provides methods for generating novel compounds, such as antibiotics, from these synthetases and associated genes.
    Type: Grant
    Filed: February 17, 2006
    Date of Patent: March 11, 2008
    Assignee: Wyeth
    Inventors: John A. Hucul, Nathan Magarvey, Michael Greenstein
  • NON-RIBOSOMAL PEPTIDE SYNTHETASES AND ASSOCIATED BIOSYNTHETIC GENES
    Publication number: 20070172909
    Abstract: The present invention describes the identification of novel non-ribosomal peptide synthetases and associated biosynthetic genes from Streptomyces hygroscopicus. The present invention further provides methods for generating novel compounds, such as antibiotics, from these synthetases and associated genes.
    Type: Application
    Filed: March 16, 2007
    Publication date: July 26, 2007
    Applicant: WYETH
    Inventors: John Hucul, Nathan Magarvey, Michael Greenstein
  • Non-ribosomal peptide synthetases and associated biosynthetic genes
    Patent number: 7195907
    Abstract: The present invention describes the identification of novel non-ribosomal peptide synthetases and associated biosynthetic genes from Streptomyces hygroscopicus. The present invention further provides methods for generating novel compounds, such as antibiotics, from these synthetases and associated genes.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: March 27, 2007
    Assignee: Wyeth
    Inventors: John A. Hucul, Nathan Magarvey, Michael Greenstein
  • Non-ribosomal peptide synthetases and associated biosynthetic genes
    Publication number: 20060269994
    Abstract: The present invention describes the identification of novel non-ribosomal peptide synthetases and associated biosynthetic genes from Streptomyces hygroscopicus. The present invention further provides methods for generating novel compounds, such as antibiotics, from these synthetases and associated genes.
    Type: Application
    Filed: February 17, 2006
    Publication date: November 30, 2006
    Applicant: Wyeth
    Inventors: John Hucul, Nathan Magarvey, Michael Greenstein
  • Biosynthetic gene cluster for the production of a complex polyketide
    Publication number: 20050272133
    Abstract: A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with 1 module, and a cytochrome P450 hydroxylase is described. Also provided are novel Streptomyces species and methods of modified Streptomyces species. Further described are novel compounds, 36-ketomeridamycin, C9-deoxomeridamycin, and C9-deoxoprolylmeridamcyin and uses thereof.
    Type: Application
    Filed: June 3, 2005
    Publication date: December 8, 2005
    Applicant: Wyeth
    Inventors: Min He, John Hucul, Bradley Haltli, Melissa Wagenaar, Edmund Graziani, Mia Summers, Kerry Kulowski, Kevin Pong
  • Non-ribosomal peptide synthetases and associated biosynthetic genes
    Publication number: 20040147007
    Abstract: The present invention describes the identification of novel non-ribosomal peptide synthetases and associated biosynthetic genes from Streptomyces hygroscopicus. The present invention further provides methods for generating novel compounds, such as antibiotics, from these synthetases and associated genes.
    Type: Application
    Filed: December 23, 2003
    Publication date: July 29, 2004
    Applicant: Wyeth
    Inventors: John A. Hucul, Nathan Magarvey, Michael Greenstein
  • Non-ribosomal peptide synthetases and associated biosynthetic genes
    Publication number: 20030219872
    Abstract: The present invention describes the identification of novel non-ribosomal peptide synthetases and associated biosynthetic genes from Streptomyces hygroscopicus. The present invention further provides methods for generating novel compounds, such as antibiotics, from these synthetases and associated genes.
    Type: Application
    Filed: March 28, 2003
    Publication date: November 27, 2003
    Applicant: WYETH
    Inventors: John A. Hucul, Nathan Magarvey, Michael Greenstein
  • Increased production of .beta.-galactosidase in aspergillus oryzae
    Patent number: 5736374
    Abstract: Novel methods are disclosed for the enhanced expression and secretion of lactase from filamentous fungi. Specifically the novel processes cause enhanced production of lactase from an Aspergillus and preferably enhanced production of A. oryzae lactase from A. oryzae host strains transformed with necessary DNA. Also described are the DNA sequence encoding the lactase gene from A. oryzae and the deduced amino acid sequence of the lactase therefrom.
    Type: Grant
    Filed: February 5, 1996
    Date of Patent: April 7, 1998
    Assignee: Genencor International, Inc.
    Inventors: Randy M. Berka, John A. Hucul, Michael Ward