Abstract: A robotic procedure system for treating neurovasculature of a patient including a guide sheath, catheter system having a support catheter and a navigation catheter, and robotic drive system configured to drive the catheter system within a patient's vessel. The robotic drive system includes a cassette with at least a first set of rollers and at least a second set of rollers and a controller operatively coupled to the cassette. The first set of rollers is configured to engage a proximal control element of the support catheter and the second set of rollers configured to engage a proximal extension of the navigation catheter. The controller is configured to control the first set and second set of rollers so as to determine a magnitude of linear translation of the support catheter and a magnitude of linear translation of the navigation catheter. Related devices, systems, and methods are provided.

Abstract: A database is stored as a plurality of database shards in a distributed database grid comprising a plurality of grid elements, each including a mid-tier database system. A first grid element receives, from an application executing in the same memory as a mid-tier database system of the first grid element, a first database transaction including at least one database operation on specific data stored in a first database shard that belongs to the first grid element. The first grid element performs and commits the first database transaction without participation of another grid element of the plurality of grid elements. The first grid element receives a second database transaction that requires access to another database shard that does not belong to the first grid element. Multiple grid elements of the plurality of grid elements perform the second database transaction and commit the second database transaction using a two-phase commit protocol.

Abstract: Disclosed herein is a methodology which quickly provides for the analysis of multiple luminescence decays from individual phosphor samples. The disclosed method utilizes a Trust-Region method to provide non-physical solutions when the fitting application was not provided with bounds for the respective intensities and decay times. Results from Double Decay were found to be statistically similar to data analyzed in methodologies known in the art.

Abstract: Methods of treating intracranial atherosclerotic disease carotid atherosclerosis, and intracranial and cerebral aneurysms by deploying implantable expandable devices. A catheter system is advanced through a base sheath towards an intracranial vessel having an atherosclerotic lesion. A tapered end region of an inner catheter is positioned distal to a distal end of an outer catheter, at least a portion of the tapered end region of the inner catheter crosses the lesion. The outer catheter is advanced over the inner catheter across the lesion. The inner catheter is withdrawn while the outer catheter is maintained in place. A stent delivery system is advanced through the catheter lumen. The outer catheter is withdrawn to unsleeve the stent and the stent delivery system maintained in place. The stent is deployed against the lesion. Related devices, systems, and methods are provided.

Abstract: A system is provided herein for stimulating an anatomical element of a patient. For example, the system may include a device (e.g., an implantable pulse generator) and an electrode device electrically coupled to the device. In some examples, the device may be configured to generate a current that is to be applied to the anatomical element via the electrode device to stimulate the anatomical element as part of a therapy aimed at achieving or supporting glycemic control in the patient. Additionally, the current may be applied to the anatomical element based on a machine learning algorithm that uses inputs gathered for determining one or more characteristics for the current. Accordingly, the machine learning algorithm may be configured to determine the one or more characteristics for the current specific to the patient (e.g., to provide personalized therapy settings for the patient).

Abstract: A system is described that includes: a first sensor that measures a glycemic level of a patient; a second sensor that measures at least one of a protein level of the patient, a hormone level of the patient, and an activity level of the patient; a processor that receives inputs from the first sensor and inputs from the second sensor; and memory including data that, when executed by the processor, enables the processor to perform one or more functions. An example of such function(s) include: analyzing the inputs received from the first sensor and the second sensor; determining, based on the analysis, that an electrical treatment is to be applied to the patient, where the electrical treatment includes application of at least one electrical signal to a nervous system of the patient; and causing the electrical treatment to be applied to the nervous system of the patient.

Abstract: A system is provided herein for stimulating an anatomical element of a patient to regulate insulin production of the patient. In some examples, the system may include a device configured to generate a current and an electrode device electrically coupled to the device. Subsequently, the device may receive instructions to apply the current to the anatomical element via a plurality of electrodes of the electrode device, where the current is configured to regulate insulin production of the patient. For example, a first electrode may be configured for placement on or around a celiac vagal trunk, where the current downregulates neural activity of the celiac vagal trunk, and a second electrode may be configured for placement on or around a hepatic vagal trunk, where the current upregulates neural activity of the hepatic vagal trunk.

Abstract: A system is provided herein for stimulating an anatomical element of a patient. For example, a device may be configured to generate a current, and an electrode device coupled to the device may be configured to apply the current to the anatomical element. In some examples, the current may be configured to prevent hypoglycemic episodes from occurring in the patient when applied to the anatomical element. For example, the current may be configured to downregulate neural activity of a celiac vagal trunk and to upregulate neural activity of a hepatic vagal trunk. Accordingly, the current being applied to anatomical element of the patient may result in a decrease in insulin production of the patient, an increase in glucose production of the patient, an increase in blood sugar levels of the patient, or a combination thereof. Additionally, applying the current may prevent nocturnal hypoglycemic episodes from occurring.

Abstract: A system is provided herein for stimulating an anatomical element of a patient. For example, a device may be configured to generate a current, and an electrode device coupled to the device may be configured to apply the current to the anatomical element. Additionally, the system may include a user interface in communication with the implantable pulse generator, the electrode device, or both. In some examples, the user interface may include a first element that is configured to display information associated with the patient. Additionally, the user interface may include a second element that is configured to receive inputs for programming parameters of the current. The user interface may also include a third element that is configured to display diagnostic information associated with applying the current to the anatomical element.

Abstract: A system is provided herein for stimulating an anatomical element of a patient. For example, the system may include a device configured to generate a current (e.g., implantable pulse generator), a first electrode device configured to apply the current to the anatomical element, and a second electrode device configured to record one or more response measurements associated with applying the current to the anatomical element. In some examples, the one or more response measurements may be used to generate growth curves associated with applying the current to the anatomical element, where the growth curves can be used to adjust one or more parameters of the current. Additionally, the one or more response measurements may include an evoked compound action potential (eCAP) measurement, an electromyography (EMG) measurement, a glucose level measurement, or a combination thereof.

Abstract: Systems and methods for mechanically blocking a nerve are provided. The system may comprise a blocking device configured to selectively compress the nerve. The system may also comprise a feedback mechanism configured to measure a response correlating to whether the nerve is blocked. When the blocking device compresses the nerve, a response from the feedback mechanism is received that correlates to the nerve being blocked or unblocked after a period of time.

Abstract: System and methods for stimulating or blocking a nerve are provided. The system may include an implantable pulse generator configured to generate a current and an electrode device in communication with the implantable pulse generator and configured to surround the nerve. The electrode device may include a housing comprising an inner surface, a first edge, and a second edge opposite the first edge; at least one electrode disposed on the inner surface and configured to apply the current to the nerve; and at least one closure configured to couple the first edge to the second edge to form a seal.

Abstract: Systems and methods for stimulating an anatomical element are provided. The system may comprise an implantable pulse generator configured to generate a current and an electrode device comprising a plurality of electrodes configured to apply the current to the anatomical element. Each of the plurality of electrodes may comprise at least one of an anode or a cathode. The electrode device may be customized by assigning each of the plurality of electrodes as at least one of an anode or a cathode and at least one of active or inactive. The current may be applied to the anatomical element in a predetermined pattern using the plurality of electrodes.

Abstract: A system is provided herein for stimulating an anatomical element of a patient to achieve glycemic control for the patient. In some examples, the system may include a device configured to generate a current and an electrode device electrically coupled to the device that includes a plurality of electrodes configured for placement on or around the anatomical element. The device may receive instructions to apply the current to the anatomical element via the plurality of electrodes of the electrode device. Additionally, the current may be applied using a first waveform of a plurality of waveforms that the device is capable of generating, where each of the plurality of waveforms comprise a substantially similar charge density. Additionally or alternatively, a system is provided that provides a pharmacological blockade at the anatomical element using a micropump that is configured to deliver a pharmacological agent to the anatomical element to achieve glycemic control.

Abstract: Systems and methods for wirelessly providing therapy to one or more anatomical elements may comprise a first capsule and a second capsule. The first capsule may be configured to wirelessly transmit instructions to a second capsule and the second capsule may be configured to receive the wirelessly transmitted instructions. The first capsule may receive an activation signal and apply a first current to a first anatomical element. The first capsule may also wirelessly transmit a first set of instructions to the second capsule to cause the second capsule to apply a second current to a second anatomical element.

Abstract: A flow diverter including a self-expanding tubular member having a plurality of expandable cells, each of the expandable cells having interconnected struts and bridges. The tubular member has a constrained configuration having a first outer diameter of at least 1.0 mm sized for delivery using a flow diverter delivery system and an expanded configuration having a second outer diameter larger than the first outer diameter. The tubular member has a proximal end zone, a distal end zone, and a middle zone located between the proximal end zone and the distal end zone. At least the middle zone of the tubular member is laser-cut to have a material coverage of at least 25% when the tubular member is in the expanded configuration. Related devices, systems, and methods of treating disease, particularly intracranial and cerebral aneurysms by deploying implantable expandable devices, are provided.

Abstract: An audio system comprises an array of transparent piezoelectric transducers on a transparent surface. Each transparent piezoelectric transducer includes one or more piezoelectric layers and one or more conductive layers that are substantially transparent to visible light. A transparent piezoelectric transducer may include, e.g., a first conductive layer, a first piezoelectric layer on the first conductive layer, and a second conductive layer on the first piezoelectric layer. Or in another example, the transparent piezoelectric transducer includes many (e.g., 20-30) piezoelectric layers and many (e.g., 20-30) conductive layers.

Abstract: An in-ear device occludes an ear canal of an ear of a user. The in-ear device is configured to be calibrated such that the user perceives audio content as though the in-ear device is not occluding the ear canal. A transducer of the in-ear device presents audio content, and an inner microphone of the in-ear device detects sound pressure data within the ear canal. A controller of the in-ear device determines a blocked sound pressure at the entrance to the ear canal based on sound pressure data from an outer microphone. The controller generates sound filters custom to the user based in part on the detected sound pressure within the ear canal and the blocked sound pressure at the entrance to the ear canal. The controller adjusts audio content using the sound filter, and the transducer presents the adjusted audio content to the user.

Abstract: A deformable image registration phantom, having a housing, an outer cylinder with a first diameter, a parallel eccentric inner cylinder with a second diameter smaller than the first diameter, a ball and socket mount, and a target. The target is mounted to the housing by way of the inner and outer cylinders and the ball and socket mount. The inner cylinder is rotatably mounted within the outer cylinder and the target is rotatably mounted, directly or indirectly, within the inner cylinder. The outer cylinder may be rotatably mounted within the housing and the ball and socket mount rotatably mounted within the inner cylinder. Alternatively, the outer cylinder may be rotatably mounted within the ball and socket mount and the ball and socket mount rotatably mounted within the housing.