Patents by Inventor John A Zoltewicz

John A Zoltewicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of nicotinic analogs for treatment of degenerative diseases of the nervous system
    Patent number: 6630491
    Abstract: Method of using anabaseine, DMAB-anabaseine, and anabaseine for stimulating brain cholinergic transmission and a method of making anabaseine.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 7, 2003
    Assignee: University of Florida
    Inventors: John A Zoltewicz, William R. Kem, Edwin M. Meyer
  • Methods of use and compositions for benzylidene- and cinnamylidene-anabaseines
    Patent number: 5977144
    Abstract: This invention relates to compositions for benzylidene- and cinnamylidene-anabaseines and methods for using these compositions for treating conditions associated with defects or malfunctioning of nicotinic subtypes brain receptors. These compositions target the alpha7 receptor subtype with little or no activation of the alpha4beta2 or other receptor subtypes.
    Type: Grant
    Filed: August 29, 1997
    Date of Patent: November 2, 1999
    Assignee: University of Florida
    Inventors: Edwin Meyer, William Kem, Franz van haaren, John A. Zoltewicz, Christopher M. De Fiebre, Roger Papke, Arthur Day
  • Synthesis of nicotinic analogs
    Patent number: 5840906
    Abstract: A process for synthesis of anabaseine using nicotinoyl piperidone salt having the formula ##STR1## wherein R.sub.1 and R.sub.2 are lower alkyl and M is a group I alkaline metal.
    Type: Grant
    Filed: February 7, 1997
    Date of Patent: November 24, 1998
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: John A. Zoltewicz, Michael P. Cruskie
  • Anabaseine derivatives useful in the treatment of degenerative diseases of the nervous system
    Patent number: 5741802
    Abstract: The invention concerns novel anabaseine-related compounds that are useful in treating certain degenerative neural diseases such as Alzheimer's and Parkinson's which apparently involve decreased function of cerebral cortical nicotinic receptors. The compounds showed activity in both in vitro and in active and passive active avoidance studies in animal models. An exemplary active compound is a 3-substituted 2,4-dimethoxy-benzylidene anabaseine.
    Type: Grant
    Filed: January 5, 1996
    Date of Patent: April 21, 1998
    Assignee: University of Florida
    Inventors: William R. Kem, John A. Zoltewicz, Edwin M. Meyer, Katalin Prokai-Tatrai
  • Synthesis of nicotinic analogs
    Patent number: 5602257
    Abstract: A novel synthesis of anabaseine using an animal nicotinoyl piperidone salt having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are lower alkyl, or R.sub.1 and R.sub.2 forms a morpholine or piperidine ring and the metal is a group I alkaline metal.
    Type: Grant
    Filed: September 9, 1994
    Date of Patent: February 11, 1997
    Assignee: University of Florida Research Foundation
    Inventors: John A. Zoltewicz, Michael P. Cruskie
  • Use of nicotinic analogs for treatment of degenerative diseases of the nervous system
    Patent number: 5516785
    Abstract: Method of using anabaseine, and DMAB-anabaseine for stimulating brain cholinergic transmission and a method of making anabaseine.
    Type: Grant
    Filed: October 21, 1993
    Date of Patent: May 14, 1996
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: John A. Zoltewicz, William R. Kem, Edwin M. Meyer