Abstract: Disclosed herein are novel microbial polycultures of two or more cell strains, capable of producing flavanones, flavonoids, and anthocyanidin-3-O-glucosides, and methods of use thereof. Also disclosed is a microbial cell capable of producing phenylpropanoic acids, and methods of use thereof.

Abstract: A materialization configuration request is received via a programmatic interface from a client of a journal-based multi-data-store database. The request indicates a partitioning rule to be used to select, for respective writes indicated in committed transaction entries of a journal, the materialization node at which the writes are to be stored. A control plane component of the database verifies that a set of materialization nodes corresponding to the partitioning rule has been established, and initiates the propagation of writes from the journal to the materialization nodes by respective write appliers.

Abstract: Disclosed herein are MEMS devices and systems and methods of manufacturing or operating the MEMS devices and systems. In some embodiments, the MEMS devices and systems are used in imaging applications.

Abstract: It is an object of the present invention to provide an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody-drug conjugate or the pharmaceutical composition, and the like. The present invention provides an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.

Abstract: The present invention provides a novel anti-DLL3 antibody-pyrrolodiazepine derivative and a novel anti-DLL3 anti-body-pyrrolodiazepine derivative conjugate using the same.

Abstract: A removable lock core for use with a lock device having a locked state and an unlocked state is disclosed. The removeable lock core may include a cam member tailpiece which is moveable between a first position relative to a lock core body which corresponds to the lock device being in the locked state and a second position relative to a lock core body which permits removal of the removeable lock core from the lock device which corresponds to the lock device being in the unlocked state. The removeable lock core may include an electro-mechanical drive assembly which in a disengaged state is decoupled from the cam member tailpiece and in an engaged state is coupled to the cam member tailpiece. A cam lock having a locked state and an unlocked state for use with a catch is disclosed.

Abstract: A feature mapping computer system configured to (i) receive a localized image including a photo depicting a driving environment and location data associated with the photo, (ii) identify, using an image recognition module, a roadway feature depicted in the photo, (iii) generate, using a photogrammetry module, a point cloud based upon the photo and the location data, wherein the point cloud comprises a set of data points representing the driving environment in a three dimensional (“3D”) space, (iv) localize the point cloud by assigning a location to the point cloud based upon the location data, and (v) generate an enhanced base map that includes a roadway feature.

Abstract: Disclosed herein are compositions and methods for delivering compositions to a subject in need of treatment for epilepsy. The disclosed compositions are orally delivered. Further disclosed are kits comprising the disclosed compositions as part of a method of delivering cannabidiol and CBD-containing compositions to subjects in need of treatment for epilepsy.

Abstract: An apparatus for scanning and decoding barcodes includes an imager, a sample imaging area, and a processor. The imager is configured to capture images within a selectable field of view. The sample imaging area is configured to support a plurality of sample/tissue containers. Each sample/tissue container of the plurality of sample/tissue containers comprises a respective barcode. At least a portion of the plurality of sample/tissue containers are positioned within the field of view, such that a plurality of the respective barcodes is within the field of view. The processor is configured to receive captured images from the imager. The processor is configured to detect and decode each of the plurality of respective barcodes present in a first image of the captured images. The processor is also configured to define an associated region of interest for each barcode present in the first image.

Abstract: The disclosures herein relate to novel compounds of formula wherein R1, R2, R3 and R4 and n are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of inflammation, neurological or psychiatric disorders associated with modulating mGlu5 receptor function.

Abstract: Systems, devices, and methods for determining a predicted impact point of a selected weapon and associated round based on stored ballistic information, provided elevation data, provided azimuth data, and provided position data.

Abstract: Embodiments described herein relate to blended meat substitute products and methods of producing the same. In some aspects, a method of producing a meat substitute product can include providing a plant based scaffolding with a carrier material, the carrier material including animal cells, adding a gelation agent to at least one of the plant-based scaffolding, and incubating the carrier material and the plant-based scaffolding in a controlled environment to produce a meat substitute product. In some embodiments, the animal cells can include at least one of skeletal muscle cells, fat cells, connective tissue cells, or skin cells.

Abstract: A distributed acoustic system (DAS) may comprise an interrogator and an umbilical line attached at one end to the interrogator, a downhole fiber attached to the umbilical line at the end opposite the interrogator. The interrogator may further include a proximal circulator, a distal circulator connected to the proximal circulator by a first fiber optic cable, and a second fiber optic cable connecting the proximal circulator and the distal circulator.

Abstract: A recycling kiosk for recycling and financial remuneration for submission of an electronic device such as a mobile phone is disclosed herein. The recycling kiosk includes electrical connectors and an inspection area with an upper chamber, a lower chamber, a transparent plate and at least one camera in order to perform a visual analysis and an electrical analysis of the electronic device for determination of a value of the electronic device. The recycling kiosk also includes a processor and a display for user interaction.

Abstract: Provided herein is an engagement and care support platform (“ECSP”) computer system including at least one processor in communication with at least one memory device for facilitating senior user engagement. The processor is programmed to: (i) register a user through an application, (ii) register a caregiver associated with the user through the application, (iii) generate a senior profile based upon user personal and scheduling data, (iv) build a daily interactive user interface that reflects the senior profile, (v) display the daily interactive user interface at a first client device associated with the user, (vi) cause the first client device to initiate a daily interaction prompt to the user, (vii) determine whether any user interaction was received in response to the daily interaction prompt, and (viii) transmit a daily update message to a second client device associated with the caregiver, including an indication of whether any user interaction was received.

Abstract: Disclosed herein are compositions and methods for delivering compositions to a subject in need of treatment for epilepsy. The disclosed compositions are orally delivered. Further disclosed are kits comprising the disclosed compositions as part of a method of delivering cannabidiol and CBD-containing compositions to subjects in need of treatment for epilepsy.

Abstract: A blow molded article, a method of making a blow molded article and a method of making a preform each having at least one layer comprising a thermoplastic resin and between 0.1% and 20% of an additive having a viscosity of greater than 1,000,000 cst. There is a refractive index difference of at least 0.04 between the additive and the thermoplastic resin. The high viscosity of the additive ensures even distribution of the additive within the thermoplastic resin in discrete domains, while additionally providing for a complex end look balancing opacity, gloss and depth.

Abstract: The disclosures herein relate to compounds of Formula (1?): or a salt thereof, wherein A, Q, X, Z, L, R2, R3 and R9 are defined herein, and their use in the treatment of SARS-CoV-2 and related viruses and disorders associated with SARS-CoV-2: Mpro.

Abstract: A system having components coupled to an aircraft in operation processes sensor-derived data, performs a localization cross-checking procedure, and dynamically generates updated analyses of the position and orientation of the aircraft. Based on the updated analyses, the system can generate instructions for flight control of the aircraft and can update flight control instructions as new data is received and processed. The system functions to reduce the “worst-case” bounds on a localization estimate for the aircraft to a low enough level that is appropriate for completing a flight operation.