Abstract: Described herein are methods and computer systems for classification of CD8 T-cell topology using a patient response-based linear cutoff model. A plurality of histology images of tissue samples in a plurality of patients are received by a computer system. An image analysis of the plurality of histology images is performed to obtain a CD8+ T-cell abundance in the tumor parenchyma and stroma in each of the plurality of histology images. Real inflammation scores and tumor infiltration scores are determined based on a polar coordinate transformation of the CD8+ T-cell abundance in the tumor parenchyma and stroma. Based on the real inflammation scores and tumor infiltration scores, a feature space is generated, and linear boundaries or linear cutoffs between a plurality of classifications in the feature space are identified based on the real inflammation scores, the tumor infiltration scores, and patient response data.

Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Abstract: Some embodiments are directed to a skin treatment system that contains a laser generating device. A hydrogel patch may include a region, at a first side of the hydrogel patch, to be in contact with a person's skin. The region may contain an adsorbing medium (e.g., carbon black or any other substance that would have a similar effect) that, when receiving a laser beam from the laser generating device, results in Extracorporeal Shock Wave Therapy (“ESWT”) being applied to the person's skin to treat a dermatologic condition such as an epidermal or dermal tissue structure irregularity, cellulite, a stretch mark, a scar, scar-tissue, a hypertrophic scar, an acne scar, etc.

Abstract: Some embodiments are directed to a cellulite treatment system that contains a laser generating device. A hydrogel patch may include a region, at a first side of the hydrogel patch, to be in contact with a person's skin. The region may contain an adsorbing medium (e.g., carbon black or any other substance that would have a similar effect) that, when receiving a laser beam from the laser generating device, results in Extracorporeal Shock Wave Therapy (“ESWT”) being applied to the person's skin to treat cellulite.

Abstract: An apparatus (such as a laser-based system) and method for providing optical pulses in a broad range of pulse widths and pulse energies uses a pulse slicer which is configured to slice a predefined portion having a desired pulse width of each of the one or more output optical pulses from a laser oscillator, in which timings of a rising edge and a falling edge of each sliced optical pulse relative to a time instance of a maximum of the corresponding each of the one or more output optical pulses from the laser oscillator, are chosen at least to maximize amplification efficiency of the optical amplifier, which may be located after the pulse slicer, and to provide the one or more amplified output optical pulses each having the desired pulse energy and pulse width.

Abstract: According to some embodiments, an apparatus for oral-motor and oral pharyngeal exercise may include an at least partially flexible, collapsible chamber formed to fit within a patient's mouth. An aperture may be formed in a flexible surface of the collapsible chamber to allow gas to flow into and out of an interior of the collapsible chamber. Moreover, a substantially inflexible wall of the collapsible chamber may be located opposite the aperture. According to some embodiments, the substantially inflexible wall incudes a coupling portion affixed to the flexible surface of the collapsible chamber and having a cleaning opening (e.g., an opening for optional cleaning). A cap portion may be adapted to be removably attached to the coupling portion to seal the interior of the collapsible chamber when attached.

Abstract: An apparatus (such as a laser-based system) and method for providing optical pulses in a broad range of pulse widths and pulse energies uses a pulse slicer which is configured to slice a predefined portion having a desired pulse width of each of the one or more output optical pulses from a laser oscillator, in which timings of a rising edge and a falling edge of each sliced optical pulse relative to a time instance of a maximum of the corresponding each of the one or more output optical pulses from the laser oscillator, are chosen at least to maximize amplification efficiency of the optical amplifier, which may be located after the pulse slicer, and to provide the one or more amplified output optical pulses each having the desired pulse energy and pulse width.

Abstract: An apparatus (such as a laser-based system) and method for providing optical pulses in a broad range of pulse widths and pulse energies uses a pulse slicer which is configured to slice a predefined portion having a desired pulse width of each of the one or more output optical pulses from a laser oscillator, in which timings of a rising edge and a falling edge of each sliced optical pulse relative to a time instance of a maximum of the corresponding each of the one or more output optical pulses from the laser oscillator, are chosen at least to maximize amplification efficiency of the optical amplifier, which may be located after the pulse slicer, and to provide the one or more amplified output optical pulses each having the desired pulse energy and pulse width.

Abstract: Some embodiments are directed to a flat screen, such a display associated with a computer monitor or smartphone, having a display side and a non-display side. The flat screen may be adapted to substantially cover a display such that the display-side is proximate to the display. The screen may substantially let visible light pass from the display side to the non-display side. The screen may not let at least a portion (e.g., a substantial portion) of a laser beam pass from the non-display side to the display side.

Abstract: An apparatus (such as a laser-based system) and method for providing optical pulses in a broad range of pulse widths and pulse energies uses a pulse slicer which is configured to slice a predefined portion having a desired pulse width of each of the one or more output optical pulses from a laser oscillator, in which timings of a rising edge and a falling edge of each sliced optical pulse relative to a time instance of a maximum of the corresponding each of the one or more output optical pulses from the laser oscillator, are chosen at least to maximize amplification efficiency of the optical amplifier, which may be located after the pulse slicer, and to provide the one or more amplified output optical pulses each having the desired pulse energy and pulse width.

Abstract: A removable cartridge is provided for use with a microdermabrasion unit. According to some embodiments, the cartridge includes a crystal source portion and a crystal waste portion. Moreover, the removable cartridge is adapted to receive a transfer apparatus from a microdermabrasion unit, the transfer apparatus being adapted to transfer crystals from the removable cartridge to the microdermabrasion unit. In other embodiments, the removable cartridge includes (i) a crystal source portion, (ii) a crystal waste portion, and (iii) a re-sealable portion adapted to prevent crystals from leaving the removable cartridge when a transfer apparatus is not present.

Abstract: A removable cartridge is provided for use with a microdermabrasion unit. According to some embodiments, the includes a crystal source portion and a crystal waste portion. Moreover, the removable cartridge is adapted to receive a transfer apparatus from a microdermabrasion unit, the transfer apparatus being adapted to transfer crystals from the removable cartridge to the microdermabrasion unit. In other embodiments, the removable cartridge includes (i) a crystal source portion, (ii) a crystal waste portion, and (iii) a re-sealable portion adapted to prevent crystals from leaving the removable cartridge when a transfer apparatus is not present. According to still other embodiments, a microdermabrasion unit includes a gravity drain to transfer crystals from a crystal source.