Abstract: The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.

Abstract: Scheduling software provides date and time allocation of resources to a sequence of processes for manufacturing a desired item. Scheduling is performed by a backward-forward method and alternatively by an backward-jump forward method to meet a requested due date. Resources are dynamically allocated to satisfy processes according to pre-established rules for allocation. Also resources are allocated in certain amounts or in a predetermined pattern to minimize waste or left over amounts of the resource. To allocate certain resources, purchase or production of the resource is scheduled first.