Patents by Inventor John Blacker
John Blacker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11965219Abstract: A process for reducing microbial growth in solutions of sugars extracted from waste materials, the process comprising monitoring indicators of microbial growth in the solution in situ and administering an antimicrobial; a sugar substrate obtained by concentrating a solution of sugar treated using the process; an apparatus for extracting sugars from waste materials, the apparatus comprising a reaction vessel (10), one or more sensors (15,20) for monitoring indicators of microbial growth in the reaction vessel, a software for analysing signals from the sensor and a source of antimicrobial.Type: GrantFiled: May 14, 2019Date of Patent: April 23, 2024Assignee: UNIVERSITY OF LEEDSInventors: Andrew John Blacker, Richard Anthony Bourne, William Robert Reynolds
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Publication number: 20210207230Abstract: A process for reducing microbial growth in solutions of sugars extracted from waste materials, the process comprising monitoring indicators of microbial growth in the solution in situ and administering an antimicrobial; a sugar substrate obtained by concentrating a solution of sugar treated using the process; an apparatus for extracting sugars from waste materials, the apparatus comprising a reaction vessel (10), one or more sensors (15,20) for monitoring indicators of microbial growth in the reaction vessel, a software for analysing signals from the sensor and a source of antimicrobial.Type: ApplicationFiled: May 14, 2019Publication date: July 8, 2021Applicant: UNIVERSITY OF LEEDSInventors: Andrew John Blacker, Richard Anthony Bourne, William Robert Reynolds
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Publication number: 20210017556Abstract: A process for oxidising a substrate selected from hydroxymethylfurfural (HMF), diformylfuran (DFF), hydroxymethylfurancarboxylic acid (HMFCA) and formylfurancarboxylic acid (FFCA). Said process comprises mixing said substrate with catalase, one or more further enzymes and hydrogen peroxide to form a reaction mixture. Said one or more further enzymes have the ability to catalyse oxidation of said substrate. Said hydrogen peroxide is provided at a total molar ratio of at least about 0.1:1 hydrogen peroxide to substrate.Type: ApplicationFiled: March 26, 2019Publication date: January 21, 2021Inventors: Paul MINES, Paul LAW, Andrew CARNELL, Shane MCKENNA, John BLACKER, Nikil KAPUR
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Patent number: 10717754Abstract: Metal complexes such as those of formula (I) are contemplated by the present invention. The metal complexes may be used in catalytic reactions as a catalyst. The catalytic reaction may be an autotransfer process, for example hydrogen borrowing. Improved catalytic activity has been observed with certain metal complexes of the invention.Type: GrantFiled: December 19, 2016Date of Patent: July 21, 2020Assignee: University of LeedsInventors: Stephen Philip Marsden, Patrick Columba McGowan, Roberta Lanaro, Andrew John Blacker
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Publication number: 20180362566Abstract: Metal complexes such as those of formula (I) are contemplated by the present invention. The metal complexes may be used in catalytic reactions as a catalyst. The catalytic reaction may be an autotransfer process, for example hydrogen borrowing.Type: ApplicationFiled: December 19, 2016Publication date: December 20, 2018Inventors: Stephen Philip MARSDEN, Patrick Columba MCGOWAN, Roberta LANARO, Andrew John BLACKER
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Publication number: 20150107965Abstract: A screw element for a screw conveyor, said screw element comprising a hub portion having a generally circular bore axially therethrough, and a spiral flight portion extending around said hub in a generally helical path; characterised in that said element comprises engagement means at each axial end thereof for mating with an adjacent element whereby torque may be transmitted between two or more adjacent screw elements via said engagement means.Type: ApplicationFiled: February 27, 2013Publication date: April 23, 2015Inventor: Kim John Blacker Price
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Patent number: 8865924Abstract: The present invention relates to compounds and their use as ligands, in particular, in metal catalyst complexes. The ligands of the invention are capable of binding to a solid support. The invention includes the ligands in their own right and when bound to a support and the compounds may be used to prepare metal catalyst complexes.Type: GrantFiled: June 7, 2013Date of Patent: October 21, 2014Assignee: University of LeedsInventors: John Blacker, Kevin Treacher, Thomas Screen
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Publication number: 20130267725Abstract: The present invention relates to compounds and their use as ligands, in particular, in metal catalyst complexes. The ligands of the invention are capable of binding to a solid support. The invention includes the ligands in their own right and when bound to a support and the compounds may be used to prepare metal catalyst complexes.Type: ApplicationFiled: June 7, 2013Publication date: October 10, 2013Applicant: UNIVERSITY OF LEEDSInventors: John Blacker, Kevin Treacher, Thomas Screen
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Patent number: 8501829Abstract: The present invention relates to compounds and their use as ligands, in particular in metal catalyst complexes. The ligands of the invention are capable of binding to a solid support. The invention includes the ligands in their own right and when bound to a support and the compounds may be used to prepare metal catalyst complexes.Type: GrantFiled: January 9, 2009Date of Patent: August 6, 2013Assignee: NPIL Pharmaceuticals (UK) LimitedInventors: John Blacker, Kevin Treacher, Thomas Screen
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Patent number: 7888083Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.Type: GrantFiled: April 27, 2010Date of Patent: February 15, 2011Assignee: AstraZeneca UK LimitedInventors: Andrew John Blacker, Christopher David Reeve, Robert Antony Holt
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Publication number: 20100298457Abstract: The present invention relates to compounds and their use as ligands, in particular in metal catalyst complexes. The ligands of the invention are capable of binding to a solid support. The invention includes the ligands in their own right and when bound to a support and the compounds may be used to prepare metal catalyst complexes.Type: ApplicationFiled: January 9, 2009Publication date: November 25, 2010Applicant: NPIL PHARMACEUTICALS (UK) LIMITEDInventors: John Blacker, Kevin Treacher, Thomas Green
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Publication number: 20100209984Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.Type: ApplicationFiled: April 27, 2010Publication date: August 19, 2010Applicant: AstraZeneca UK LimitedInventors: Andrew John BLACKER, Christopher David REEVE, Robert Anthony HOLT
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Patent number: 7732171Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.Type: GrantFiled: July 23, 2008Date of Patent: June 8, 2010Assignee: AstraZeneca UK LimitedInventors: Andrew John Blacker, Christopher David Reeve, Robert Antony Holt
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Publication number: 20090163719Abstract: There is provided a process for the de-enrichment of enantiomerically enriched compositions which comprises reacting an enantiomerically enriched composition comprising at least a first enantiomer or diastereomer of a substrate comprising a carbon-heteroatom bond, wherein the carbon is a chiral centre and the heteroatom is a group V heteroatom, in the presence of a catalyst system and optionally a reaction promoter to give a product composition comprising first and second enantiomers or diastereomers of the substrate having a carbon-heteroatom bond, the ratio of second to first enantiomer or diastereomer in the product composition being greater than the ratio of second to first enantiomer or diastereomer in the enantiomerically enriched composition.Type: ApplicationFiled: October 27, 2005Publication date: June 25, 2009Inventors: Andrew John Blacker, Matthew John Stirling
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Publication number: 20090069579Abstract: A process for preparing intermediate compounds useful in the preparation of statins. The process is particularly useful for the preparation of atorvastatin. The process involves the reduction of two ketone groups at the same time using either a chiral transition metal catalyst or an enzyme based system.Type: ApplicationFiled: November 21, 2006Publication date: March 12, 2009Inventors: John Blacker, Robin Fieldhouse
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Publication number: 20080280336Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.Type: ApplicationFiled: July 23, 2008Publication date: November 13, 2008Applicant: ASTRAZENECA UK LIMITEDInventors: Andrew John Blacker, Christopher David Reeve, Robert Anthony Holt
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Patent number: 7416865Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.Type: GrantFiled: April 27, 2006Date of Patent: August 26, 2008Assignee: AstraZeneca UK LimitedInventors: Andrew John Blacker, Christopher David Reeve, Robert Antony Holt
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Patent number: 7408082Abstract: The present invention relates to a novel process for obtaining (1S,4S)N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine from a mixture of its isomers. The process involves isomerising the 1-position and the 4-position and effecting separation of the desired isomer by methods such as fractured crystallization. The process can be operated as a continuous process.Type: GrantFiled: August 9, 2007Date of Patent: August 5, 2008Assignee: NPIL Pharmaceuticals (UK) LimitedInventor: John Blacker
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Patent number: 7250526Abstract: A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal hydrocarbyl complex which is coordinated to defined bidentate ligands substituted with at least one group selected from an optionally substituted sulphonated hydrocarbyl group, a sulphonated perhalogenated hydrocarbyl group, or an optionally substituted sulphonated heterocyclyl group. Preferred metals include rhodium, ruthenium and iridium. Preferred bidentate ligands are diamines and aminoalcohols, particularly those comprising chiral centres. The hydrogen donor is advantageously a secondary alcohol or a mixture of triethylamine and formic acid. The process can be employed to transfer hydrogenate ketones and imines, which are preferably prochiral. Catalysts for use in such a process are also provided.Type: GrantFiled: November 29, 2001Date of Patent: July 31, 2007Assignee: NPIL Pharmaceuticals (UK) LimitedInventors: Andrew John Blacker, Christian Bubert, Jonathan Michael Jeremy Williams, Stephen Martin Brown
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Patent number: 7157255Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.Type: GrantFiled: May 1, 2001Date of Patent: January 2, 2007Assignee: AstraZeneca UK LimitedInventors: Andrew John Blacker, Christopher David Reeve, Robert Antony Holt