Patents by Inventor John Blazeck

John Blazeck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HUMAN KYNURENINASE ENZYMES AND USES THEREOF
    Publication number: 20230405049
    Abstract: Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
    Type: Application
    Filed: April 6, 2023
    Publication date: December 21, 2023
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: George GEORGIOU, Everett STONE, John BLAZECK, Christos KARAMITROS
  • Human kynureninase enzymes and uses thereof
    Patent number: 11648272
    Abstract: Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: May 16, 2023
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: George Georgiou, Everett Stone, John Blazeck, Christos Karamitros
  • Human kynureninase enzyme variants having improved pharmacological properties
    Patent number: 11542486
    Abstract: Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: January 3, 2023
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: George Georgiou, Everett Stone, John Blazeck
  • ADMINISTRATION OF KYNURENINE DEPLETING ENZYMES FOR TUMOR THERAPY
    Publication number: 20220275099
    Abstract: Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
    Type: Application
    Filed: October 11, 2021
    Publication date: September 1, 2022
    Inventors: George GEORGIOU, Everett STONE, Nicholas MARSHALL, John BLAZECK, Wei-Cheng LU
  • Administration of kynurenine depleting enzymes for tumor therapy
    Patent number: 11168142
    Abstract: Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: November 9, 2021
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: George Georgiou, Everett Stone, Nicholas Marshall, John Blazeck, Wei-Cheng Lu
  • HUMAN KYNURENINASE ENZYME VARIANTS HAVING IMPROVED PHARMACOLOGICAL PROPERTIES
    Publication number: 20210207110
    Abstract: Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
    Type: Application
    Filed: March 2, 2017
    Publication date: July 8, 2021
    Inventors: George GEORGIOU, Everett STONE, John BLAZECK
  • Compositions and methods for lipid production
    Patent number: 10920233
    Abstract: Described herein, inter alia, are compositions, oleagnious organisms, and methods useful for producing lipids, lipid precursors, and/or oleochemicals.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: February 16, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: John Blazeck, Andrew Hill, Leqian Liu, Hal Alper
  • HUMAN KYNURENINASE ENZYMES AND USES THEREOF
    Publication number: 20190350975
    Abstract: Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
    Type: Application
    Filed: April 16, 2019
    Publication date: November 21, 2019
    Inventors: George GEORGIOU, Everett STONE, John BLAZECK, Christos KARAMITROS
  • ADMINISTRATION OF KYNURENINE DEPLETING ENZYMES FOR TUMOR THERAPY
    Publication number: 20190002579
    Abstract: Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
    Type: Application
    Filed: April 25, 2018
    Publication date: January 3, 2019
    Inventors: George GEORGIOU, Everett STONE, Nicholas MARSHALL, John BLAZECK, Wei-Cheng LU
  • COMPOSITIONS AND METHODS FOR LIPID PRODUCTION
    Publication number: 20180201943
    Abstract: Described herein, inter alia, are compositions, oleagnious organisms, and methods useful for producing lipids, lipid precursors, and/or oleochemicals.
    Type: Application
    Filed: December 27, 2017
    Publication date: July 19, 2018
    Inventors: John Blazeck, Andrew Hill, Leqian Liu, Hal Alper
  • Administration of kynurenine depleting enzymes for tumor therapy
    Patent number: 9975959
    Abstract: Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: May 22, 2018
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: George Georgiou, Everett Stone, Nicholas Marshall, John Blazeck, Wei-Cheng Lu
  • Compositions and methods for lipid production
    Patent number: 9896691
    Abstract: Described herein, inter alia, are compositions, oleagnious organisms, and methods useful for producing lipids, lipid precursors, and/or oleochemicals.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: February 20, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventors: John Blazeck, Andrew Hill, Leqian Liu, Hal Alper
  • ENGINEERED FUNGI FOR ITACONIC ACID PRODUCTION
    Publication number: 20170327850
    Abstract: Genetically engineered oleaginous fungi (e.g., engineered Yarrowia lipolytica) are provided for use in itaconic acid production. In some aspects, the engineered fungi comprise a transgene for expression of a cis-aconitic acid decarboxylase (CAD) enzyme and, optionally, one or more further genetic modifications. Methods and culture systems for production of itaconic acid using such fungi are also provided.
    Type: Application
    Filed: October 29, 2015
    Publication date: November 16, 2017
    Inventors: Hal ALPER, John BLAZECK, Andrew HILL
  • ADMINISTRATION OF KYNURENINE DEPLETING ENZYMES FOR TUMOR THERAPY
    Publication number: 20160058845
    Abstract: Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
    Type: Application
    Filed: August 28, 2015
    Publication date: March 3, 2016
    Inventors: George GEORGIOU, Everett STONE, Nicholas MARSHALL, John BLAZECK, Wei-Cheng LU
  • COMPOSITIONS AND METHODS FOR LIPID PRODUCTION
    Publication number: 20140329287
    Abstract: Described herein, inter alia, are compositions, oleagnious organisms, and methods useful for producing lipids, lipid precursors, and/or oleochemicals.
    Type: Application
    Filed: May 2, 2014
    Publication date: November 6, 2014
    Applicant: Board of Regents, The University of Texas System
    Inventors: John Blazeck, Andrew Hill, Leqian Liu, Hal Alper