Abstract: The invention is directed to a method for recovering at least one product from a fermentation broth. The invention relates to the use of a vacuum distillation vessel to recover products, such as ethanol, from a fermentation broth, where the fermentation broth comprises viable microbial biomass, and where the recovery of the product is completed in such a manner to ensure the viability of the microbial biomass. The invention provides for product recovery at an effective rate so as to prevent the accumulation of product in the fermentation broth. To ensure the viability of the microbial biomass, the invention is designed to reduce the amount of stress on the microbial biomass. By ensuring the viability of the microbial biomass, the microbial biomass may be recycled and reused in the fermentation process, which may result in an increased efficiency of the fermentation process.

Abstract: A method of identifying an antifungal agent which targets a PPTB protein of a fungus comprising determining whether a candidate compound binds to or inhibits a PPTB protein, wherein binding or inhibition indicates that the candidate substance is an antifungal agent.

Abstract: A method of identifying an antifungal agent which targets a DHODH protein (alias PyrE, dihydroorotate dehydrogenase, EC: 1.3.99.11) of a fungus comprising contacting a candidate substance with a fungal DHODH protein and determining whether the candidate substance binds or modulates the DHODH protein, wherein binding or modulation indicates that the candidate substance is an antifungal agent. Specific examples concern Aspergillus fumigatus and Candida albicans DHODH proteins. DHODH inhibitors with a Quinazolinone core are also disclosed.

Abstract: The present invention relates to a process for the preparation of fermented food wherein a carboxypeptidase preparation is used to obtain accelerated fungal growth.

Abstract: A method of identifying an antifungal agent which targets a PPTB protein of a fungus comprising determining whether a candidate compound binds to or inhibits a PPTB protein, wherein binding or inhibition indicates that the candidate sub-stance is an antifungal agent.

Abstract: A method of identifying an antifungal agent which targets a DHODH protein (alias PyrE, dihydroorotate dehydrogenase, EC: 1.3.99.11) of a fungus comprising contacting a candidate substance with a fungal DHODH protein and determining whether the candidate substance binds or modulates the DHODH protein, wherein binding or modulation indicates that the candidate substance is an antifungal agent. Specific examples concern Aspergillus fumigatus and Candida albicans DHODH proteins. DHODH inhibitors with a Quinazolinone core are also disclosed.

Abstract: Method of identifying an anti-fungal agent which targets as an essential protein or gene of a fungus comprising contacting a candidate substance with (i) a protein which comprises the sequence shown by SEQ ID NOS: 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 39, 42, 45, 48, 50, 53, 56, 59, 61 or 63, or (ii) a protein which has 60% identity with (i), or (iii) a protein comprising a fragment of (i) or (ii) which fragment has a length of at least 50 amino acids, or (iv) a polynucleotide that comprises a sequence which encodes (i), (ii) or (iii), or (v) a polynucleotide comprising a sequence which has at least 70% identity with the coding sequence of (iv), and determining whether the candidate substance binds or modulates (i), (ii), (iii), (iv), or (v), wherein binding or modulation of (i), (ii), (iii), (iv), or (v) indicates that the candidate substance is an anti-fungal agent.

Abstract: The present invention relates to a process for the preparation of fermented food wherein a carboxypeptidase preparation is used to obtain accelerated fungal growth.

Abstract: Method of identifying an anti-fungal agent which targets an essential protein or gene of a fungus comprising contacting a candidate substance with (i) a NADH:flavin oxidoreductase protein which comprises the sequence shown by SEQ ID NO:3, (ii) a NADH:flavin oxidoreductase protein which is a homologue of (i) and which comprises the sequence shown by SEQ ID NO: 8, 12, 14, 19, 24, 42, 44, 83 or 85, (iii) a protein which has 50% identity with (i) or (ii), (iv) a protein comprising a fragment of (i), (ii) or (iii) which fragment has a length of at least 50 amino acids, (v) a polynucleotide that comprises sequence which encodes (i), (ii), (iii) or (iv), (vi) a polynucleotide comprising sequence which has at least 70% identity with the coding sequence of (v), and determining whether the candidate substance binds or modulates (i), (ii), (iii), (iv), (v) or (vi), wherein binding or modulation of (i), (ii), (iii), (iv), (v) or (vi) indicates that the candidate substance is an anti-fungal agent.

Abstract: An ARM Development Environment (ADE) PCBA and platform. The ADE platform advantageously allows software development for processors, including the current ARM9 processor and its peripherals on a stable, well-known piece of hardware. A wide range of product types can be assembled from subsets of the features of the present invention. The invention allows engineers to experiment with system architecture, user interface, and software development while product-specific hardware and mechanical assemblies are being produced.

Abstract: An apparatus and method for detecting water loss from a swimming pool includes a first container having an upper end, a lower end, an inner cavity and at least one opening allowing swimming pool water to flow in and out of said inner cavity; a substantially waterproof load cell positioned within the inner cavity of said first container, for measuring weight bearing thereon; and a second container having an upper end, a lower end, and an inner cavity closed to water flow, said second container positioned within the inner cavity of said first container having its lower end upon said load cell so as to bear weight thereon.

Abstract: An apparatus and method for detecting water loss from a swimming pool includes a first container having an upper end, a lower end, an inner cavity and at least one opening allowing swimming pool water to flow in and out of said inner cavity; a substantially waterproof load cell positioned within the inner cavity of said first container, for measuring weight bearing thereon; and a second container having an upper end, a lower end, and an inner cavity closed to water flow, said second container positioned within the inner cavity of said first container having its lower end upon said load cell so as to bear weight thereon.

Abstract: An apparatus and method for detecting water loss from a swimming pool includes a first container having an upper end, a lower end, an inner cavity and at least one opening allowing swimming pool water to flow in and out of said inner cavity; a substantially waterproof load cell positioned within the inner cavity of said first container, for measuring weight bearing thereon; and a second container having an upper end, a lower end, and an inner cavity closed to water flow, said second container positioned within the inner cavity of said first container having its lower end upon said load cell so as to bear weight thereon.

Abstract: An apparatus and method for detecting water loss from a swimming pool includes a first container having an upper end, a lower end, an inner cavity and at least one opening allowing swimming pool water to flow in and out of said inner cavity; a substantially waterproof load cell positioned within the inner cavity of said first container, for measuring weight bearing thereon; and a second container having an upper end, a lower end, and an inner cavity closed to water flow, said second container positioned within the inner cavity of said first container having its lower end upon said load cell so as to bear weight thereon.

Abstract: An apparatus and method for detecting water loss from a swimming pool includes a first container having an upper end, a lower end, an inner cavity and at least one opening allowing swimming pool water to flow in and out of said inner cavity; a substantially waterproof load cell positioned within the inner cavity of said first container, for measuring weight bearing thereon; and a second container having an upper end, a lower end, and an inner cavity closed to water flow, said second container positioned within the inner cavity of said first container having its lower end upon said load cell so as to bear weight thereon.

Abstract: An efficient, powerful and reliable system for amplifying optical pulses. Seed-pulses are generated by a seed-pulse source and are transmitted to an optical amplifier for amplification. The power for the amplification is provided by a Q-switched, diode-pumped, extracavity frequency-doubled pump laser.

Abstract: An efficient, powerful and reliable system for amplifying optical pulses. Seed-pulses are generated by a seed-pulse source and are transmitted to an optical amplifier for amplification. The power for the amplification is provided by a Q-switched, diode-pumped, intracavity-doubled pump laser.

Abstract: An efficient, powerful and reliable system for amplifying optical pulses. Seed-pulses are generated by a seed-pulse source and are transmitted to an optical amplifier for amplification. The power for the amplification is provided by a Q-switched, diode-pumped, intracavity-doubled pump laser.

Abstract: An efficient, powerful and reliable system for amplifying optical pulses. Seed-pulses are generated by a seed-pulse source and are transmitted to an optical amplifier for amplification. The power for the amplification is provided by a Q-switched, diode-pumped, intracavity-doubled pump laser.