Abstract: Compositions and methods for mitochondria genome editing are provided. Also provided are methods for treating mitochondrial disorders by the disclosed compositions.

Abstract: Embodiments of the disclosure can include various electrical assemblies. In one embodiment, an electrical assembly can include a module including at least one module switching element and an energy storage device, the or each module switching element and the energy storage device in the module arranged to be combinable to selectively provide a voltage source; and a shorting device directly connected to first and second terminals of the energy storage device, the shorting device including a first shorting switching element configured to be switchable between: a first switching state to isolate the first and second terminals from each other; and a second switching state to electrically connect the first and second terminals to short the energy storage device.

Abstract: A portable barricade includes a road plate, first and second support posts extending upward from end portions of the road plate, a barricade arm extending between the first and second support posts, and a lift coupled one of the end portions of the barricade arm and a corresponding one of the first and second support posts. Actuation of the lift is configured to slide the barricade arm relative to the first and second support members between a retracted position proximate to the road plate and a deployed position distal from the road plate.

Abstract: A portable barricade includes a road plate, first and second support posts extending upward from end portions of the road plate, a barricade arm extending between the first and second support posts, and a lift coupled one of the end portions of the barricade arm and a corresponding one of the first and second support posts. Actuation of the lift is configured to slide the barricade arm relative to the first and second support members between a retracted position proximate to the road plate and a deployed position distal from the road plate.

Abstract: An electrical assembly comprises a plurality of modules (36), each module (36) including at least one switching element (38) and at least one energy storage device (40), the or each switching element (38) and the or each energy storage device (40) in each module (36) arranged to be combinable to selectively provide a voltage source, wherein each module (36) includes a respective sensor (46) that is configured to monitor at least one other of the plurality of modules (36), each sensor (46) configured to selectively detect an occurrence of an operational hazard in the or each corresponding monitored module (36).

Abstract: Provided herein, inter alia, are compositions, including compounds comprising a polynucleotide covalently linked to a cyanine moiety. In embodiments, polynucleotides comprise a nucleotide sequence that is fully complementary to a nucleotide sequence of a mitochondrial polynucleotide. Methods of using such compounds are also provided, including for targeting mitochondrial DNA, such as for cleaving, modifying, or altering the expression of mitochondrial DNA.

Abstract: A portable bollard for arresting motion of a vehicle includes a post, a base plate coupled to the post, a top plate coupled to the post and spaced apart from the base plate along a length of the post, and a tapered member extending from a surface of the top plate facing the base plate to the post. The tapered member tapers from a wider end at the surface of the top plate to a narrower end at the post. The top plate is rotationally offset from the base plate.

Abstract: A portable barricade includes a road plate, first and second support posts extending upward from end portions of the road plate, a barricade arm extending between the first and second support posts, and a lift coupled one of the end portions of the barricade arm and a corresponding one of the first and second support posts. Actuation of the lift is configured to slide the barricade arm relative to the first and second support members between a retracted position proximate to the road plate and a deployed position distal from the road plate.

Abstract: An amphibious transport apparatus includes forward and aft ends, a pair of spaced apart pontoons including tracks, and a transversely extending structure, which can include a platform, that spans between the pontoons and connects the pontoons together. The amphibious transport apparatus further includes a sled vessel that can be used to transport materials or personnel. The sled can be releasably attached to the amphibious transport apparatus with tow bar and a pivotal connection. Said tow bar can be rotatable between an upper storage position wherein the tow bar engages the vessel away from said pivotal connection and above a terrain surface, and a lower towing position.

Abstract: A portable bollard for arresting motion of a vehicle includes a post, a base plate coupled to the post, a top plate coupled to the post and spaced apart from the base plate along a length of the post, and a tapered member extending from a surface of the top plate facing the base plate to the post. The tapered member tapers from a wider end at the surface of the top plate to a narrower end at the post. The top plate is rotationally offset from the base plate.

Abstract: An amphibious transport apparatus includes forward and aft ends, a pair of spaced apart pontoons including tracks, and a transversely extending structure, which can include a platform, that spans between the pontoons and connects the pontoons together. The amphibious transport apparatus further includes a sled vessel that can be used to transport materials or personnel. The sled can be releasably attached to the amphibious transport apparatus with tow bar and a pivotal connection. Said tow bar can be rotatable between an upper storage position wherein the tow bar engages the vessel away from said pivotal connection and above a terrain surface, and a lower towing position.

Abstract: Compositions and methods for mitochondria genome editing are provided. Also provided are methods for treating mitochondrial disorders by the disclosed compositions.

Abstract: A portable bollard for arresting motion of a vehicle includes a post, a base plate coupled to the post, a top plate coupled to the post and spaced apart from the base plate along a length of the post, and a tapered member extending from a surface of the top plate facing the base plate to the post. The tapered member tapers from a wider end at the surface of the top plate to a narrower end at the post. The top plate is rotationally offset from the base plate.

Abstract: A portable bollard for arresting motion of a vehicle includes a post, a base plate coupled to the post, a top plate coupled to the post and spaced apart from the base plate along a length of the post, and a tapered member extending from a surface of the top plate facing the base plate to the post. The tapered member tapers from a wider end at the surface of the top plate to a narrower end at the post. The top plate is rotationally offset from the base plate.

Abstract: An apparatus and method for selectively placing either an auger type or a ground rod or rod type anchor into the earth includes a machine frame that supports an elongated housing. The housing has upper and lower end portions. An anchor holder is positioned at the lower end of a tubular member rotatably mounted in the housing for holding an auger type anchor and rotating it during placement. If a ground rod or rod type anchor is selected, a drive that is offset from the housing central longitudinal axis drives the rod into the earth and without rotating the rod.

Abstract: An amphibious transport apparatus includes forward and aft ends, a pair of spaced apart pontoons including tracks, and a transversely extending structure, which can include a platform, that spans between the pontoons and connects the pontoons together. The amphibious transport apparatus further includes a sled vessel that can be used to transport materials or personnel. The sled can be releasably attached to the amphibious transport apparatus with tow bar and a pivotal connection. Said tow bar can be rotatable between an upper storage position wherein the tow bar engages the vessel away from said pivotal connection and above a terrain surface, and a lower towing position.

Abstract: An inspection system that is effective to collect images of a part under inspection. This inspection system includes (a) a three axis linear motion stage; (b) a rotary fourth axis stage configured to hold and rotate an object to be inspected. This rotary fourth axis stage is mounted on the three axis linear stage; (c) a fifth axis camera and optical system mounted to one of the axes of the three axis linear motion stage. This fifth axis camera has an optical axis substantially parallel to the axis of linear motion; (d) a 45 degree mirror configured to bend the optical axis of the fifth axis camera by 90° to point towards the object; and (e) a motor configured to rotate the mirror over a range of angles to obtain a fifth axis of viewing orientation.

Abstract: An inspection system that is effective to collect images of a part under inspection. This inspection system includes (a) a three axis linear motion stage; (b) a rotary fourth axis stage configured to hold and rotate an object to be inspected. This rotary fourth axis stage is mounted on the three axis linear stage; (c) a fifth axis camera and optical system mounted to one of the axes of the three axis linear motion stage. This fifth axis camera has an optical axis substantially parallel to the axis of linear motion; (d) a 45 degree mirror configured to bend the optical axis of the fifth axis camera by 90° to point towards the object; and (e) a motor configured to rotate the mirror over a range of angles to obtain a fifth axis of viewing orientation.