Abstract: The present disclosure relates to guidewire devices having shapeable tips and effective torquability. A guidewire device includes a core having a proximal section and a tapered distal section. A tube structure is coupled to the core such that the tapered distal section extends into the tube structure. The tube structure includes a plurality of bypass cuts formed tangentially within the tube structure to increase the flexibility of the tube structure and to reduce the tendency of resilient forces from the tube structure to disrupt a shaped distal tip of the guidewire device.

Abstract: The invention provides compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a donor, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the compositions and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various stem cell disorders, including hematological, among others.

Abstract: The invention provides compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a donor, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the compositions and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various stem cell disorders, including hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others.

Abstract: Counter-flow heat exchanged is constructed with plenums at either end that separate the opposing fluids, the channels of which are arrayed in a checkerboard patterns, such that any given channel is surrounded by channels of opposing streams on four sides—laterally on both sides and vertically above and below.

Abstract: Counter-flow heat exchanger is constructed with plenums at either end that separate the opposing fluids, the channels of which are arrayed in a checkerboard patterns, such that any given channel is surrounded by channels of opposing streams on four sides—laterally on both sides and vertically above and below.

Abstract: Counter-flow heat exchanged is constructed with plenums at either end that separate the opposing fluids, the channels of which are arrayed in a checkerboard patterns, such that any given channel is surrounded by channels of opposing streams on four sides—laterally on both sides and vertically above and below.

Abstract: The invention provides methods, uses and compositions for the treatment of ankylosing spondylitis (AS). The invention describes methods and uses for treating ankylosing spondylitis, wherein a TNF? inhibitor, such as human TNF? antibody, or antigen-binding portion thereof, is used to reduce signs and symptoms of ankylosing spondylitis in a subject. Also described are methods for determining the efficacy of a TNF? inhibitor for treatment of ankylosing spondylitis in a subject.

Abstract: Counter-flow heat exchanger is constructed with plenums at either end that separate the opposing fluids, the channels of which are arrayed in a checkerboard patterns, such that any given channel is surrounded by channels of opposing streams on four sides—laterally on both sides and vertically above and below.

Abstract: Counter-flow heat exchanger is constructed with plenums at either end that separate the opposing fluids, the channels of which are arrayed in a checkerboard patterns, such that any given channel is surrounded by channels of opposing streams on four sides—laterally on both sides and vertically above and below.

Abstract: The invention provides methods, uses and compositions for the treatment of ankylosing spondylitis (AS). The invention describes methods and uses for treating ankylosing spondylitis, wherein a TNF? inhibitor, such as human TNF? antibody, or antigen-binding portion thereof, is used to reduce signs and symptoms of ankylosing spondylitis in a subject. Also described are methods for determining the efficacy of a TNF? inhibitor for treatment of ankylosing spondylitis in a subject.

Abstract: A signal lighting system for a vehicle includes a housing having an open front end. A bottom and top of the housing each have an arcuate front edge. The bottom extends farther forward than the top so the front edge of the bottom is in front of the front edge of the top. The system includes a plurality of lights between the bottom and top and positioned for directing light generally forward. Gaskets are at the front edges of the top and bottom of the housing for conforming the lighting system to a windshield of the vehicle. The lighting system is adjustable to facilitate mounting the lighting system in a wide range of different makes and models of vehicle notwithstanding differences that may exist between their windshield geometries. The lights may be included in light modules that can be rotationally adjusted while the system is mounted on the vehicle.

Abstract: In one embodiment, a method includes recording a sequence of online activities of a first user. The online activities include online consumption of online content by the first user. The method includes constructing a path based on the sequence of online activities of the first user. The path includes a sequence of online activity points that each correspond to one of the online activities in the sequence of online activities of the first user, and the path enables a second user to experience personally for themselves at least an approximation of the sequence of online activities of the first user. The method includes communicating the path for traversal of a portion of the path by the second user.

Abstract: The invention provides methods, uses and compositions for the treatment of ankylosing spondylitis (AS). The invention describes methods and uses for treating ankylosing spondylitis, wherein a TNF? inhibitor, such as a human TNF? antibody, or antigen-binding portion thereof, is used to reduce signs and symptoms of ankylosing spondylitis in a subject. Also described are methods for determining the efficacy of a TNF? inhibitor for treatment of ankylosing spondylitis in a subject.

Abstract: System that delivers heating and/or cooling to multiple zones using two or more thermodynamic cycles that are tailored specifically to the overall load and in so doing provide a heating or cooling effect at high efficiency using only a single work fluid and a single accumulator connected to two or more external media.

Abstract: In particular embodiments, a method for editing a web page includes identifying a plurality of components that collectively form a programmatic representation of a first web page. At least one of the components has content that dynamically changes in response to data retrieved externally from the content. A second web page is generated. The second web page includes a plurality of parameters. Each parameter of the second web page corresponds to a respective one of the identified plurality of components. One or more modifications made to the plurality of parameters are interpreted. A programmatic representation of a third web page is generated, the generation based at least in part on the interpretation.

Abstract: Counter-flow heat exchanger is constructed with plenums at either end that separate the opposing fluids, the channels of which are arrayed in a checkerboard patterns, such that any given channel is surrounded by channels of opposing streams on four sides—laterally on both sides and vertically above and below.

Abstract: A signal lighting system for a vehicle includes a housing having an open front end. A bottom and top of the housing each have an arcuate front edge. The bottom extends farther forward than the top so the front edge of the bottom is in front of the front edge of the top. The system includes a plurality of lights between the bottom and top and positioned for directing light generally forward. Gaskets are at the front edges of the top and bottom of the housing for conforming the lighting system to a windshield of the vehicle. The lighting system is adjustable to facilitate mounting the lighting system in a wide range of different makes and models of vehicle notwithstanding differences that may exist between their windshield geometries. The lights may be included in light modules that can be rotationally adjusted while the system is mounted on the vehicle.

Abstract: A system comprising a power supply, an emergency warning light and a speaker, in combination with a control head. One or more processors controls operation of the system in response to received user input and provides system status for display. Storage media encoded with emergency warning light system instructions for execution by one or more of the processors controls the actuation of the emergency warning light system and controls light patterns generated by the emergency warning light system. The storage media is further encoded with siren system instructions for execution by one or more of the processors for controlling the actuation of the siren system and for controlling audible sounds generated by the siren system.

Abstract: A solar light bar includes a battery isolator adapted to be connected between a bus and a vehicle charging system for isolating a vehicle battery from the bus and for selectively connecting the bus to the charging system. A light source switch connects the light source and the bus for selectively electrically connecting the light source to the bus. When the light source switch is closed, the light source is energized by electricity from at least one of the solar panel, the charging system and the auxiliary battery. When the light source switch is open, the light source is isolated from the bus. The auxiliary battery is adapted to be selectively charged by electricity from at least one of the solar panel and the charging system.