Abstract: A method for creating new educational, and theme party products in the form of full color 3D paper napkin entities that resemble the entity that the napkin fold or origami fold is named for. Color patterns are applied to square paper napkins or serviettes which, with the like origami fold, creates a fun challenge to the individual folder to achieve the correct folded outcome. The paper napkins are both functional for everyday use, and are folding fun for seasonal & theme parties, birthdays, and are educational as they stimulate conversation and the creative mind while folding.

Abstract: The present disclosure relates to a compound of formula (I) or a salt thereof, wherein variable A, B, and X are as defined herein. The disclosure also relates to covalent conjugates of formula (II). The disclosure further relates to the use of the compounds of formula (I) and covalent conjugates of formula (II) in methods for detecting a change in the pH of a mixture.

Abstract: A method for creating new educational, and theme party products in the form of full color 3D paper napkin entities that resemble the color image likeness the entity that the napkin fold or origami fold is named for. By combining color napkin or origami patterns applied to the art or industry medium of square paper napkins or serviettes with the intention of matching the pattern to the like named fold or origami fold, creates a fun challenge to the individual folder to achieve the correct folded outcome. The paper napkins are both functional for everyday use, and are folding fun for seasonal & theme parties, birthdays, and are educational as they stimulate conversation and the creative mind while folding.

Abstract: The present invention provides for compounds of Formula I and II: wherein y, X, Y, Z, R1, and R2 have any of the values defined there for in the specification. The compounds of formula I are useful as reagents in the isolation and the assay of PQQ dependent enzymes. Also provided are compositions comprising compounds of Formula I and II.

Abstract: The present invention provides for compounds of Formula I: wherein X—N and R1-R4 have any of the values disclosed in the specification. The compounds of Formula I are useful as reagents to introduce N-alkyl nucleosides into DNA oligonucleotides. The present invention also provides for methods of synthesizing the compounds of Formula I.

Abstract: The present invention provides for compounds of Formula I and II: wherein y, X, Y, Z, R1, and R2 have any of the values defined there for in the specification. The compounds of formula I are useful as reagents in the isolation and the assay of PQQ dependent enzymes. Also provided are compositions comprising compounds of Formula I and II.

Abstract: The present invention provides for reagents for the introduction of colorimetric-oxycarbonyl protecting groups, compounds bearing colorimetric-oxycarbonyl protecting groups, and the use thereof in solid-supported organic syntheses of oligonucleotides, polypeptides, polysaccharides, and combinatorial libraries.

Abstract: The present invention provides for reagents for the introduction of colorimetric-oxycarbonyl protecting groups, compounds bearing colorimetric-oxycarbonyl protecting groups, and the use thereof in solid-supported organic syntheses of oligonucleotides, polypeptides, polysaccharides, and combinatorial libraries.

Abstract: Novel polymer-supported quenching reagents of Formula I, P—L—Q  I wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one or more chemically robust linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.

Abstract: A clasp for holding two ends of cords or the like together includes a shaft member insertable into and engageable with a latch member. The latch member is a round tube having an open front end through which the shaft member may be inserted and withdrawn. Attached to the latch member is a spring member with a hook (tab) extending from a free end thereof through a hole in the side of the latch member. The shaft has a notch. The clasp is engaged by aligning the tab of the latch member with the notch of the shaft member and pushing the shaft member into the open end of the latch member until the tab engages the notch. The clasp is disengaged by rotating the shaft member relative to the latch member so that the tab is urged out of the notch, then pulling the shaft member out of the latch member.

Abstract: A vehicle chassis and body measurement system and method of operation thereof is disclosed. The measurement system uses light-reflective targets placed at known offsets from measurement points on a vehicle. The system has a measuring head that directs two beams of light from the head at the light-reflective targets. When the light reflects back from the targets to the head, it is sensed and enables the system to determine the location of the target. The lights in the head are adjusted by the system until the reflected light signal disappears. The system can determine the relative position of the vehicle measurement points using the calculated target location measurements and the manually measured position of the targets.

Abstract: Novel polymer-supported quenching reagents of Formula (I): P-L-Q, wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one or more chemically robust linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.

Abstract: Substrates and inhibitors for the cysteine protease Ich-1 are disclosed. These compounds are designed based on an optimal minimal substrate for Ich-1 and include reversible inhibitors, irreversible inhibitors, selectively reversible inhibitors, chromogenic substrates, fluorogenic substrates and radiolabeled substrates/inhibitors. Pharmaceutical compositions comprising the compounds of the invention are also provided. Methods for inhibiting the proteolytic activity of Ich-1, methods for detecting the presence of Ich-1 and methods for isolating Ich-1 using the compounds of the invention are also disclosed.

Abstract: A process for the attachment of aromatic or heteroaromatic rings to a polymeric support via a silyl ether linkage is described. Such process involves the synthesis of a chlorodialkyl aryl or heteroarylsilane which is then coupled to a polymeric support via a hydroxyl functionality to form a polymer-bound silyl ether. Further modification provides a polymer-bound small organic molecule that is cleaved from the polymeric support under mild conditions to give an aryl or heteroaryl silanol or a compound in which the aryl or heteroaryl carbon-silicon bond is replaced with a carbon-hydrogen, carbon-halogen, carbon-hydroxyl, carbon-sulfur, or carbon—carbon bond. Such methods are useful for the preparation of a library of diverse aromatic and heteroaromatic compounds by both manual and automated synthesis.

Abstract: A device and methods to measure the wheel alignment, to measure the position and orientation of the wheels in relation to the chassis, to measure the chassis and body and to measure parameters of vehicles for problem diagnosis. A beam of colliminated light is directed along a latitudinal reference line. The angle and distance relationship of the wheels to this line are measured. A light beam perpendicular to the latitudinal reference light beam is directed longitudinal to the vehicle. The latitudinal light beam and the longitudinal light beams form a rectangular grid system from which the position of vehicle chassis parts can be measured. A method to calculate and compensate for the errors in the measurement system is used with gravity sensors to more accurately calculate toe, camber and tilt. These angular relations provide toe relative the chassis, camber, caster, s.a.i. and included angle. Also, offset and setback of the front and rear wheels relative to the chassis are provided.

Abstract: A method for the multiple, simultaneous synthesis of compounds comprising the steps of: 1) providing an apparatus comprising a plurality of reaction tubes having filter members on their lower ends, a reservoir member for receiving the filter member, a holder member having a plurality of apertures for supporting the reaction tubes, and a manifold member adjacent to the holder member and enclosing the upper ends of the reaction tubes; 2) charging the apparatus with reactants required for synthesis; 3) synthesizing the compounds in solution; or optionally 4) cleaving the compounds from a solid support within the apparatus.

Abstract: Novel inhibitors of protein farnesyltransferase enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer and restenosis.

Abstract: This invention relates to novel substituted 1,2,3,4-tetrahydroisoquinolines which are useful in the treatment of vascular restenosis, various disorders of the central nervous system, in the regulation of female reproductive functions, in cognitive enhancement, in atherosclerosis and in treating excessive AVP secretory disorders. Novel intermediates useful in the preparation of the compounds are also disclosed. Methods of using the compounds and pharmaceutical compositions containing them are disclosed.

Abstract: This invention relates to novel substituted 1,2,3,4-tetrahydroisoquinolines which are useful in the treatment of vascular restenosis, various disorders of the central nervous system, in the regulation of female reproductive functions, in cognitive enhancement, in atherosclerosis and in treating excessive AVP secretory disorders. Novel intermediates useful in the preparation of the compounds are also disclosed. Methods of using the compounds and pharmaceutical compositions containing them are disclosed.

Abstract: The present invention relates to the use of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acids and analogs thereof in antagonizing the binding of angiotensin II to AT.sub.2 receptors to treat memory loss.