Abstract: The present disclosure provides human interleukin 4 receptor alpha antibody glucocorticoid receptor agonist conjugates and methods of using the conjugates for the treatment of inflammatory diseases, such as type 2 inflammatory diseases.

Abstract: The present disclosure provides human tumor necrosis factor alpha antibody glucocorticoid receptor agonist conjugates and methods of using the conjugates for the treatment of autoimmune and inflammatory diseases.

Abstract: A cloud-based system for use by retail store employees or customers at any location to facilitate the sale of automotive tires to consumers is provided. The system accesses multiple independent tire inventory systems from different distributors/manufacturers and provides a personalized set of recommendation tire options and accompanying TPMS service packs.

Abstract: A device for preventing unwanted opening of a locked enclosure includes a lock bolt moveable between a locked position and an unlocked position. A face gear is meshable with and rotatable by the worm gear between locking and unlocking positions when the worm gear is driven in the first and second directions, respectively. A blocker member is rotatable between first and second positions. A biasing member is operatively coupled to the face gear and the blocker member to bias the blocker member in a biasing direction. A sliding member selectively disengages the blocker member to allow the blocker member to rotate in the biasing direction. A lever arm is operatively coupled to the sliding member such that the lever arm is in the disengaged and engageable positions when the sliding member engages the blocker member in the first and second positions, respectively.

Abstract: A skin grafting system includes a plurality of hollow microneedles actuatable between a retracted position and an extended position. The system further includes a rigid member coupled to plurality of hollow microneedles, and a latch assembly having at least one latch moveably coupled to the latch assembly. The at least one latch is configured to move during actuation of the plurality of hollow microneedles, and the at least one microneedles are in the extended position.

Abstract: An identification module is disclosed for use in a key making machine. The identification module may have a key receiving assembly configured to receive only a shank of an existing key. The identification module may also have a tip guide, configured to receive a tip of the shank of the existing key. The tip guide may have a slot that exposes a tip end of the shank. The identification module may also have an imaging assembly configured to capture an image of the tip end through the slot.

Abstract: The present inventors identified a subpopulation of genes induced by type I and type II IFNs in a human submandibular gland (HSG) epithelial cell line. Unexpectedly, it was found that the majority of genes that are highly up-regulated by IFN-? are also highly induced by IFN-?. In contrast, there was a substantial group of genes that are highly induced by IFN-? only. In target tissues, this identified subpopulation of genes and probes allow different IFN patterns to be discerned, enabling more precise molecular classification of patient subpopulations. The identified gene probes are useful for selecting and monitoring therapy, and for defining efficacy of novel agents in the autoimmune rheumatic diseases.

Abstract: Disclosed is a medical assembly, according to various embodiments, for providing a therapy to a subject. The assembly is operable to be held relative to a subject for a trial period. The holder may allow for connections and/or passage of connections from the medical device to allow for appropriate or a selected operation of the medical device.

Abstract: A viscous food dispensing system includes a chute inlet configured to funnel particulate food product into a sleeve and a transport device having an over-center cutout. The transport device is configured to rotate within the sleeve to convey the particulate food product. A processing surface extends downward from the chute inlet towards a curved base of the sleeve along a portion of the transport device. The processing surface is spaced laterally apart from the transport device to define a processing zone between the processing surface and the transport device. The particulate food product is processed as the particulate food product is captured between a leading edge of the over-center cutout and the processing surface while the transport device is rotating.

Abstract: The present inventors identified a subpopulation of genes induced by type I and type II IFNs in a human submandibular gland (HSG) epithelial cell line. Unexpectedly, it was found that the majority of genes that are highly up-regulated by IFN-? are also highly induced by IFN-?. In contrast, there was a substantial group of genes that are highly induced by IFN-? only. In target tissues, this identified subpopulation of genes and probes allow different IFN patterns to be discerned, enabling more precise molecular classification of patient subpopulations. The identified gene probes are useful for selecting and monitoring therapy, and for defining efficacy of novel agents in the autoimmune rheumatic diseases.

Abstract: A system for detecting the presence of pests, the system comprising: at least one remote camera system, each of the at least one remote camera system comprising an image capture device coupled to a processor and a wireless transmitter, each of the at least one remote camera system having a pest detection surface and being configured to: capture one or more image of the pest detection surface; process the captured one or more image to recognise the potential presence of a target pest on the pest detection surface; and transmit data from the captured one or more image in response to recognising the potential presence of one or more target pests; and a server configured to: receive the transmitted data; process the transmitted data to verify the potential presence of the target pest on the pest detection surface; and provide an output indicating the verification.

Abstract: A system receives asset data indicating assets that have an uncertainty contributing to a financial risk of a portfolio. The system controls a multi-stage financial risk estimate process by determining a first portion and a second portion of the asset data; and computing, for the first portion, a first stage of the process. The system computes a second stage of the process for the first portion in an overlapping time period as computing the first stage for the second portion. The system, responsive to a completion of all computations of the process for the first portion, aggregates a computed risk according to the process for the first portion with any previously computed risks for other portions of the asset data besides the first and second portion. The system outputs an estimate for the financial risk for the portfolio before completing the process for the second portion.

Abstract: A system for detecting the presence of pests, the system comprising: at least one remote camera system, each of the at least one remote camera system comprising an image capture device coupled to a processor and a wireless transmitter, each of the at least one remote camera system having a pest detection surface and being configured to: capture one or more image of the pest detection surface; process the captured one or more image to recognise the potential presence of a target pest on the pest detection surface; and transmit data from the captured one or more image in response to recognising the potential presence of one or more target pests; and a server configured to: receive the transmitted data; process the transmitted data to verify the potential presence of the target pest on the pest detection surface; and provide an output indicating the verification.

Abstract: A gravity-feed bin includes a generally hollow main bin having an open end, a storage reservoir and a dispensing chute. The dispensing chute has an opening disposed near a distal end. The bin includes a dispensing gate movable between open and closed positions. When the dispensing gate is in the closed position, the dispensing gate blocks the opening of the dispensing chute. One or more fins contact interior and/or exterior surfaces of the gate to provide cleaning functionality of the gate and/or sealing functionality between the gate and the dispensing chute.

Abstract: An identification module is disclosed for use in a key making machine. The identification module may have a key receiving assembly configured to receive only a shank of an existing key. The identification module may also have a tip guide, configured to receive a tip of the shank of the existing key. The tip guide may have a slot that exposes a tip end of the shank. The identification module may also have an imaging assembly configured to capture an image of the tip end through the slot.

Abstract: A gravity-feed bin includes a generally hollow main bin having an open end, a storage reservoir and a dispensing chute. The dispensing chute has an opening disposed near a distal end. The bin includes a dispensing gate movable between open and closed positions. When the dispensing gate is in the closed position, the dispensing gate blocks the opening of the dispensing chute. One or more fins contact interior and/or exterior surfaces of the gate to provide cleaning functionality of the gate and/or sealing functionality between the gate and the dispensing chute.

Abstract: A viscous food product dispensing system having a transport section for receiving a particulate food product from a bin, an auger for processing and conveying the received particulate food product from the transport section into an outlet adapter via one or more flutes, a milling device housed in the outlet adapter, and a discharge nozzle in the outlet adapter that pinches off the viscous food product created by the milling device. The auger has a unique design that allows it to engage and break whole nuts.

Abstract: A system for detecting the presence of pests, the system comprising: at least one remote camera system, each of the at least one remote camera system comprising an image capture device coupled to a processor and a wireless transmitter, each of the at least one remote camera system having a pest detection surface and being configured to: capture one or more image of the pest detection surface; process the captured one or more image to recognise the potential presence of a target pest on the pest detection surface; and transmit data from the captured one or more image in response to recognising the potential presence of one or more target pests; and a server configured to: receive the transmitted data; process the transmitted data to verify the potential presence of the target pest on the pest detection surface; and provide an output indicating the verification.

Abstract: A system/method for producing a substance attractive to one or more species of insect characterised by: housing a population of live insects; providing any combination of nutrients, food or water to the live insects; removing organic matter from the population; and sterilizing the removed organic matter.

Abstract: A nozzle for a viscous food dispensing system configured to dispense a viscous food product includes a nozzle passage extending from a nozzle inlet to a nozzle outlet, and a first port positioned proximate the nozzle outlet. A valve insert is positioned within the nozzle passage between the nozzle inlet and the first port, and the valve insert includes a second port. The first port and the second port are configured to move between an open position and a closed position in which flow from the nozzle inlet to the nozzle outlet is restricted by the second port then restricted by the first port.