Abstract: A computer readable media, a method, and a system registering a third party application providing an available communication system between a local user and a remote user identity, storing information related to the available communication system in a first database, obtaining contact information for the remote user identity from the third party application, determining a communication type for the third party application, pairing the remote user identity with a contact, and updating a graphical representation of contact information.

Abstract: Machine learning-based part selection in relation to one or more end use environmental conditions is provided. The process includes training a machine learning model to facilitate evaluation of a part for use in a product based on an environmental condition. Further, the process includes receiving measurement data for the part, and establishing a score for the part by comparing the measurement data for the part to a specification for the part. In addition, the method includes using the machine learning model and the established score for the part in determining whether to use the part in the product based on the environmental condition.

Abstract: A computer-implemented method is disclosed that includes operations of parsing a query comprised of a sequence of operators to detect each operator of the sequence of operators, where the sequence of operators includes a machine learning (ML) operator representing a trained ML model. Additionally, a schema of the ML operator is determined through metadata. A filter or a projection is generated based on the schema of the ML operator, where the filter or projection is configured to reduce an amount of data retrieved upon application of the filter of the projection to an operator of the sequence of operators comprising the query. The schema of the ML operator indicates a schema of input data to be provided to the ML operator and a schema of output data to be provided by the ML operator following processing.

Abstract: A computer-implemented method for integration of machine learning components within a pipelined search query to generate a visualization is described. Herein, an interface is provided for receipt of pipelined code into a web-based programming application. The pipelined code features a series of operators configured to perform one or more tasks based on collective operations by the series of operators, wherein a first operator of the series of operators is to receive input data from a selected data source and each remaining operator of the series of operators to receive input based on an output from a preceding operator of the remaining operators. The task(s) performed by the pipelined code generate results including visualizations. The visualization is rendered in a manner that allows the pipelined code to be scrolled to display the pipelined code or the visualization.

Abstract: A computer-implemented method is disclosed including operations of receiving a request to store a representation of a machine learning model in a non-transitory computer-readable medium, validating the representation of the machine learning model, storing the representation of the machine learning model, receiving a query from a web-based programming application, the query including a sequence of operators, parsing the query to detect and identify each operator within the sequence of operators, converting the query to directed acyclic graph (DAG) and providing the DAG to a distributed processing engine configured to execute the DAG. The computer-implemented method includes further operations of, prior to converting the query to the DAG, altering the query to improve efficiency of execution of the DAG. Altering the query may include at least one of consolidating at least two operators, applying a filter operation to an operator, or applying a projection to the operator.

Abstract: According to one embodiment, a method that supports queries deploying operators based on multiple programming languages is described. A sequence of operators associated with a query is identified, where the sequence of operators includes at least two neighboring operators including a first operator based on a first programming language and a second operator based on a second programming language that is different from the first programming language. Thereafter, a schema associated with the first operator and a schema associated with the second operator is determined along with the compatibility between the schema of the first operator and the schema of the second operator. A query error message is generated in response to incompatibility between the first operator schema and the second operator schema. Compatibility is determined when an output generated by execution of the first operator provides machine data needed as input for execution of the second operator.

Abstract: A computer-implemented method is disclosed that includes operations of receiving a query to be executed, the query including an indication of a data source at which input data is be to obtained, wherein the query is to be executed on the input data, determining a schema of the input data, determining fields of the input data that are required for execution of the query by analyzing a sequence of operators forming the query, determining one or more alterations to the query to improve efficiency of the execution of the query based on the fields of input data required for the execution, and generating an altered query be altering the query in accordance with the one or more alterations. The method may further include converting the query to a directed acyclic graph (DAG) and providing the DAG to a distributed processing engine configured to execute the DAG.

Abstract: Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided: wherein each R is independently selected from the group consisting of H, C(O)X, C(O)NHX, NH(CO)X, SO2NHX, and NHSO2X, wherein X is selected from the group consisting of an alkyl, a substituted alkyl, an aryl, a substituted aryl, an alkylaryl, and a heterocycle. Compounds of group A may be used for treating various diseases or disorders, such as cancer.

Abstract: The invention provides Bcl-G polypeptides and encoding nucleic acids. Bcl-G polypeptides include Bcl-GL and Bcl-GS. The invention also provides mouse Bcl-G. The invention also provides vectors containing Bcl-G nucleic acids, host cells containing such vectors, Bcl-G anti-sense nucleic acids and related compositions. The invention additionally provides Bcl-G oligonucleotides that can be used to hybridize to or amplify a Bcl-G nucleic acid. Anti-Bcl-G specific antibodies are also provided. Further provided are kits containing Bcl-G nucleic acids or Bcl-G specific antibodies. Such kits and reagents can be used to diagnose cancer, monitor response to therapy, or predict the prognosis of a cancer patient. The invention additionally provides methods of modulating apoptosis using Bcl-G polypeptides, encoding nucleic acids, or compounds that modulate the activity or expression of Bcl-G polypeptides. The methods for modulating apoptosis can be used to treat diseases such as cancer.

Abstract: An assay for identifying compounds that affect conversion of Bcl-2 family protein from an antiapoptotic to a proapoptotic form or inhibit activity of Bcl-2 family protein is described.

Abstract: The present invention provides a method for treating cancer in a mammal comprising contacting the cancer cells with a compound which is a apogossypol, derivative.

Abstract: The present invention provides a method for treating cancer in a mammal comprising contacting the cancer cells with a compound which is a apogossypol, derivative.

Abstract: Methods for screening for inhibitors of endoplasmic reticulum (ER) stress are provided. These methods involve the addition of thapsigargin, which induces ER stress, and a test agent to mammalian cells in multi-well plates. Cell survival can be readily monitored by measuring intracellular ATP content using a bioluminescent reagent. Screening a commercially available library of 50,000 compounds led to the identification of 93 hit compounds that were subjected to secondary assays to confirm their ability to rescue cells from thapsigargin-induced cell death.

Abstract: Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.

Abstract: The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a caspase such as caspase-3 or caspase-7 or a pro-caspase such as pro-caspase-9, or that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP. The invention further provides methods of reducing the severity of a pathologic condition in an individual by administering to the individual an agent that alters the caspase inhibitory activity of an IAP.

Abstract: Provided herein are compositions and methods of detecting Bcl-B expression in cancer cells to prognose, monitor, or select therapies for cancers such as breast cancer, prostate cancer, lung cancer, or gastric cancer.

Abstract: The invention provides polypeptides comprising inhibitor of apoptosis protein (IAP) family members, such as BmIAP initially derived from Bombyx mori BmN cells, and nucleic acids encoding them, and methods for making and using these compositions, including their use for inhibiting apoptosis.