Abstract: An extension for the handle bars of a motorcycle includes an insert with a projection that fits within the handle bars. The handle bars and insert are keyed so as to prevent rotational movement thereof relative to each other. A parallel bar that is clamped to the handle bars retains all of the parts in place.

Abstract: This invention relates to novel sequence and polymorphisms in the human flt-1 gene. Eight specific polymorphisms are identified. The invention also relates to methods and materials for analysing allelic variation in the flt-1 gene and to the use of flt-1 polymorphism in the diagnosis and treatment of angiogenic diseases and cancer. Diseases associated with pathological angiogenesis include diabetic retinopathies, psoriasis, rheumatoid arthritis and endometriosis.

Abstract: This invention relates to polymorphisms in the human pyruvate dehydrogenase complex E2 (PDH E2 or PDC E2) gene and corresponding novel allelic polypeptides encoded thereby. The invention also relates to methods and materials for analysing allelic variation in the PDH E2 gene, and to the use of PDH E2 polymorphism in the diagnosis and treatment of. diseases in which modulation of pyruvate dehydrogenase activity could be of therapeutic benefit, such as diabetes, asthma, obesity, sepsis and peripheral vascular disease. In particular, the invention is based on the discovery of two single nucleotide polymorphisms (SNPs) in the coding region of the human PDH E2 gene.

Abstract: This invention relates to polymorphisms in the human pyruvate dehydrogenase E1&bgr; (PDH E1&bgr;) gene. The invention also relates to methods and materials for analysing allelic variation in the PDH E1&bgr; gene, and to the use of PDH E1&bgr; polymorphism in the diagnosis and treatment of diseases in which modulation of pyruvate dehydrogenase activity could be of therapeutic benefit, such as diabetes, asthma, obesity, sepsis and peripheral vascular disease. In particular, the invention is based on the discovery of a single nucleotide polymorphism in the coding region of the human PDH E1&bgr; gene, and three single nucleotide polymorphisms in the 3′ untranslated region (3′UTR) of the human PDH E1&bgr; gene.

Abstract: A plate joiner including a fence support, a drive, and a fence system. The fence support includes a cutter and a contact surface, which defines a cutter slot. The cutter is arranged and configured to protrude from fence support through cutter slot to make a plunge cut into a surface of a workpiece when the contact surface is pressed against the surface and the cutter is plunged into the workpiece by pushing on a rearward handle portion of the tool. The drive is arranged and configured to rotatably drive the cutter through a motor. As shown in the drawings a preferred fence system includes an angle adjustment system arranged and configured to position the fence at a wide range of fence angles and, at any selected distance from a top face of the workpiece to the fence, the distance from the top face of the workpiece to the cutter remains constant as the front fence angle is adjusted. A preferred fence system includes a trunnion which pivotally couples the front fence to the fence system.

Abstract: A tight-buffered optical fiber includes an optical fiber, at least a first buffer layer of a polymer material enclosing the optical fiber, and a plurality of strength members embedded in the first buffer layer and longitudinally disposed around the optical fiber. A second buffer layer of polymer material may also be formed to enclose the first buffer layer. The first and second buffer layer may be made of acrylate and may be either radiation or thermally curable. The second buffer layer may also have a plurality of strength members embedded in it and longitudinally disposed around the optical fiber.

Abstract: This invention relates to novel sequence and polymorphisms in the human flt-1 gene. Eight specific polymorphisms are identified. The invention also relates to methods and materials for analysing allelic variation in the flt-1 gene and to the use of flt-1 polymorphism in the diagnosis and treatment of angiogenic diseases and cancer. Diseases associated with pathological angiogenesis include diabetic retinopathies, psoriasis, rheumatoid arthritis and endometriosis.

Abstract: A plate joiner including a fence support, a drive, and a fence system. The fence support includes a cutter and a contact surface, which defines a cutter slot. The cutter is arranged and configured to protrude from fence support through cutter slot to make a plunge cut into a surface of a workpiece when the contact surface is pressed against the surface and the cutter is plunged into the workpiece by pushing on a rearward handle portion of the tool. The drive is arranged and configured to rotatably drive the cutter through a motor. A preferred fence system includes an angle adjustment system arranged and configured to position the fence at a wide range of fence angles and, at any selected distance from a top face of the workpiece to the fence, the distance from the top face of the workpiece to the cutter remains constant as the front fence angle is adjusted. A preferred fence system includes a trunnion which pivotally couples the front fence to the fence system.

Abstract: This invention relates to polymorphisms in the human prostaglandin E2 receptor 1 (EP1-R) gene and corresponding novel allelic polypeptides encoded thereby. Fourteen specific polymorphisms are identified. The invention also relates to methods and materials for analysing allelic variation in the EP1-R gene and to the use of said polymorphism in the diagnosis and treatment of EP1-R ligand mediated diseases, such as cancer or arthritis.

Abstract: A plate joiner including a fence support, a drive, and a fence system. The fence support includes a cutter and a contact surface, which defines a cutter slot. The cutter is arranged and configured to protrude from fence support through cutter slot to make a plunge cut into a surface of a workpiece when the contact surface is pressed against the surface and the cutter is plunged into the workpiece by pushing on a rearward handle portion of the tool. The drive is arranged and configured to rotatably drive the cutter through a motor.

Abstract: A plate joiner including a fence support, a drive, and a fence system. The fence support includes a cutter and a contact surface, which defines a cutter slot. The cutter is arranged and configured to protrude from fence support through cutter slot to make a plunge cut into a surface of a workpiece when the contact surface is pressed against the surface and the cutter is plunged into the workpiece by pushing on a rearward handle portion of the tool. The drive is arranged and configured to rotatably drive the cutter through a motor. A preferred fence system includes an angle adjustment system arranged and configured to position the fence at a wide range of fence angles and, at any selected distance from a top face of the workpiece to the fence, the distance from the top face of the workpiece to the cutter remains constant as the front fence angle is adjusted. A preferred fence system includes a trunnion which pivotally couples the front fence to the fence system.

Abstract: Improvements made to a router relate to a fine adjust depth stop system. The preferred router comprises a micro-adjust knob coupled to a threaded member within one of a plurality of plunge guide posts. A depth stop nut is coupled to the treaded member such that the nut travels up and down the threaded member as the mirco-adjust knob is rotated. The location of the nut within the plunge guide post defined a depth stop position for the motor housing relative to a router base. When the motor housing is located at the depth stop position, the stop point, and thus the motor housing, will move up and down relative to the base as the micro-adjust knob is rotated.

Abstract: A plate joiner including a fence support, a drive, and a fence system. The fence support includes a cutter and a contact surface, which defines a cutter slot. The cutter is arranged and configured to protrude from fence support through cutter slot to make a plunge cut into a surface of a workpiece when the contact surface is pressed against the surface and the cutter is plunged into the workpiece by pushing on a rearward handle portion of the tool. The drive is arranged and configured to rotatably drive the cutter through a motor.A preferred plate joiner includes a cutter plunge system arranged and configured to provide a plurality of release positions that reduce the distance traveled in making a plunge cut for a smaller blade and to prevent a blade from protruding from the tool in a release position.

Abstract: The present disclosure relates to an angle grinder including an elongated handle body having front and rear portions. The handle body has a greater nominal width proximate the front portion than proximate the rear portion. A recessed hand grip portion is defined by the handle body between the front and rear handle portions. The recessed hand grip portion transitions inward to a nominal girth that is smaller than the girth of both the front and rear portions. The recessed hand grip portion also includes a leading front wall that transitions from the smaller nominal girth of the grip portion toward the larger nominal girth of the front portion. The leading front wall is aligned at an angle that slopes in a forward direction as the leading front wall extends from the top side toward the bottom side of the handle body. The disclosure also relates to an angle grinder having a switch paddle pivotally connected to a handle.

Abstract: A plate joiner including a fence support, a drive, and a fence system. The fence support includes a cutter and a contact surface, which defines a cutter slot. The cutter is arranged and configured to protrude from fence support through cutter slot to make a plunge cut into a surface of a workpiece when the contact surface is pressed against the surface and the cutter is plunged into the workpiece by pushing on a rearward handle portion of the tool. The drive is arranged and configured to rotatably drive the cutter through a motor.A preferred plate joiner is configured for substantially continuous adjustment of fence height while restraining lateral and tortional movement of the fence and providing an accurate measure of the height of the fence from any point in the thickness of the blade.

Abstract: An ink composition is disclosed including a colorant and at least one polymer selected from the group consisting of polyvinylimidazole, derivatives of polyvinylimidazole, copolymers of vinylimidazole and copolymers of vinylimidazole derivatives. The present invention also relates to ink compositions including a colorant and at least one polymer selected from polyvinylpyridine, derivatives of polyvinylpyridine, copolymers of vinylpyridine and copolymers of vinylpyridine derivatives. Also disclosed is an ink composition comprising a pigment and at least one polymer selected from the group consisting of polyethyleneimine and derivatives thereof. Further disclosed is a method for generating printed images which include incorporating into a printing apparatus the ink compositions described above and generating an image onto a substrate.

Abstract: A holder for a pair of cylindrical battery cells includes a carrier which retains the batteries in parallel side-by-side relationship and in series electrical connection. The cells are installed into a housing longitudinally and the housing is formed with guide channels for guiding and substantially surrounding the cells. At the ends of the guide channels, there are provided contact elements for electrically connecting the battery cells to circuitry. Electric shock hazard to a user is eliminated because the internal contact elements are inaccessible to the operator, even when the carrier is removed from the housing.