Abstract: A positive displacement type substance sampling and dispensing device comprises a central plunger formed from a first material. A plunger housing is formed from a second material having a melting point lower than the first material, the housing being formed by molding and setting the second material on to the surface of the plunger so that the plunger can slide in the housing to draw a substance into it.

Abstract: A medical device having a housing (2) with a bore (3) and a lancet (1) slidably fitting in the bore. The lancet operates as a positive displacement piston. In a retracted position, in which the lancet is rearwardly displaced along the bore to define a fluid-containing space in the bore forwardly on the lancet tip, the fluid-containing space has a cross-section dimension to allow fluid to be retained therein by surface tension. The device has a seal (6) operable substantially to prevent flow of fluid from the fluid-containing space past the seal means on movement of the lancet. Displacement of the lancet between the puncture and retracted positions provides suction for drawing fluid into and along the fluid-containing space from the forward end of the bore, and/or pressure for expelling fluid from the fluid-containing space via the forward end of the bore. Also disclosed are methods for operating the device.

Abstract: A chemical and bio-chemical assay method is described which screens compounds for enzyme inhibition, or receptor or other target binding. Inhibition or binding by the library compounds causes a change in the amount of an optically detectable label that is bound to suspendable cells or solid supports. The amounts of label bound to individual cells or solid supports are microscopically determined, and compared with the amount of label that is not bound to individual cells or solid supports. The degree of inhibition or binding is determined using this data. Confocal microscopy, and subsequent data analysis, allow the assay to be carried out without any separation step, and provide for high throughput screening of very small assay volume using very small amounts of test compound.

Abstract: An apparatus for use with an optical scanning or observation system. The apparatus comprises a drawer for receiving, in use, a sample carrier to be scanned or observed. A first clamp member, engages, in use, with one surface of a sample carrier in the drawer. A second clamp member is arranged to engage, in use, with the side of the sample carrier opposite to that of the first clamp member, the second clamp member having an optical window formed therein to enable viewing, in use, of a sample carrier. The first and second clamping members are arranged in use to move the sample carrier out of engagement with the drawer so that the sample carrier is supported solely on the clamping members.

Abstract: The present invention provides an improved beverage chiller comprising at least two interconnected canisters each canister defining a chamber for refrigerant. The chamber includes a plurality of pipes extending along the length of the chamber for the flow of beverage thereghrough. Each canister includes flow control means to ensure flow of beverage up and down the refrigerant chamber in a plurality of cooling passes. The refrigerant chambers are pressure balanced and arranged to be coupled to a source of refrigeration via a thermostatic expansion valve.