Patents by Inventor John Chiefari
John Chiefari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11522220Abstract: An electrolyte composition comprising (i) a block copolymer, (ii) an organic electrolyte (e.g. an ionic liquid), and (iii) a lithium salt, wherein the block copolymer comprises a non-ionic block and an ionic block, the non-ionic block comprising polymerised residues of hydrophobic monomers, and the ionic block comprising polymerised monomer residues having covalently coupled thereto (a) a pendant organic ionic liquid cation, the pendant organic ionic liquid cation having a counter anion, (b) a pendant anionic moiety, the pendant anionic moiety having a counter cation, or (c) a combination thereof, and the electrolyte composition has at least two glass transition temperature (Tg) values.Type: GrantFiled: November 2, 2018Date of Patent: December 6, 2022Assignee: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATIONInventors: John Chiefari, Kristine Barlow, Nicolas Goujon, Xiaojuan Hao, Maria Forsyth, Patrick C. Howlett
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Publication number: 20200405881Abstract: Provided herein are engineered cells and methods for engineering cells to deliver a therapeutic agent, e.g., a small molecule, peptide or other drug, to a cell or tissue to be treated.Type: ApplicationFiled: March 6, 2018Publication date: December 31, 2020Applicants: UNIVERSITY OF WASHINGTON, SEATTLE CHILDREN'S RESEARCH INSTITUTE, COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATIONInventors: Patrick S. STAYTON, Anthony CONVERTINE, Debobrato DAS, Hye-Nam SON, Selvi SRINIVASAN, Katherine MONTGOMERY, Ian BLUMENTHAL, Courtney CRANE, Michael JENSEN, James MATTHAEI, John CHIEFARI, Maarten DANIAL, Fei HUANG, James MACDONALD, Almar POSTMA, Kathleen TURNER
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Publication number: 20200280095Abstract: An electrolyte composition comprising (i) a block copolymer, (ii) an organic electrolyte (e.g. an ionic liquid), and (iii) a lithium salt, wherein the block copolymer comprises a non-ionic block and an ionic block, the non-ionic block comprising polymerised residues of hydrophobic monomers, and the ionic block comprising polymerised monomer residues having covalently coupled thereto (a) a pendant organic ionic liquid cation, the pendant organic ionic liquid cation having a counter anion, (b) a pendant anionic moiety, the pendant anionic moiety having a counter cation, or (c) a combination thereof, and the electrolyte composition has at least two glass transition temperature (Tg) values.Type: ApplicationFiled: November 2, 2018Publication date: September 3, 2020Applicant: Commonwealth Scientific and Industrial Research OrganisationInventors: John Chiefari, Kristine Barlow, Nicolas Goujon, Xiaojuan Hao, Maria Forsyth, Patrick C. Howlett
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Publication number: 20200276318Abstract: Provided herein are engineered cells and methods for engineering cells to deliver a therapeutic agent, e.g., a small molecule, peptide or other drug, to a cell or tissue to be treated.Type: ApplicationFiled: March 6, 2018Publication date: September 3, 2020Applicants: UNIVERSITY OF WASHINGTON, SEATTLE CHILDREN'S RESEARCH INSTITUTE, COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATIONInventors: STAYTON S. Patrick, Katherine MONTGOMERY, Courtney CRANE, Michael JENSEN, John CHIEFARI, James MACDONALD, Maarten DANIAL, Fei HUANG, Almar POSTMA, Kathleen TURNER
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Publication number: 20190358341Abstract: The present invention provides a biocompatible and hydrophilic polymer conjugate comprising a linear, aliphatic copolymer backbone to which is conjugated a binding moiety and an agent. The binding moiety is conjugated to an end of the copolymer backbone and facilitates targeted delivery of the agent. Also provided are methods for preparing such polymer conjugates via free radical polymerisation techniques such as reversible addition fragmentation chain transfer (RAFT) polymerisation and uses of such polymer conjugates in diagnosis or therapy.Type: ApplicationFiled: December 22, 2017Publication date: November 28, 2019Inventors: Timothy ADAMS, John CHIEFARI, Xiaojuan HAO, Fei HUANG, Laurence MEAGHER, Judith SCOBLE, Charlotte WILLIAMS
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Patent number: 9650450Abstract: The invention provides for a process for removing thiocarbonylthio groups from polymer prepared by RAFT polymerization, the process comprising: introducing into a flow reactor a solution comprising the RAFT polymer in solvent; and promoting a reaction within the flow reactor that removes the thiocarbonylthio groups so as to form a solution that flows out of the reactor comprising the RAFT polymer absent the thiocarbonylthio groups.Type: GrantFiled: December 14, 2012Date of Patent: May 16, 2017Assignee: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATIONInventors: John Chiefari, Christian Hornung, Almar Postma, Simon Saubern
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Patent number: 9340498Abstract: A method of preparing polymer, the method comprising polymerizing one or more ethylenically unsaturated monomers of formula (I) where U is selected from H, C1-C4 alkyl or halogen; V is halogen or of the form O-G where G is selected from —C(O)R1 and —R1, or V is of the form NGGa where G is as defined above and Ga is selected from H and R1, G and Ga form together with N a heterocyclic ring, or V is of the form CH2Gb where Gb is selected from H, R1, OH, OR1, NR12, PR12, P(O)R12, P(OR1)2, SR1, SOR1, and SO2R1; and where the or each R1 is independently selected from optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl, optionally substituted alkylaryl, optionally substituted alkylheteroaryl, and an optionally substituted polymer chain, under the control of a RAType: GrantFiled: January 22, 2010Date of Patent: May 17, 2016Assignee: COMMONWEALTH SCIENTIFIC and INDUSTRIAL RESERACH ORGANISATIONInventors: Ezio Rizzardo, John Chiefari, Massimo Benaglia, San Thang, Graeme Moad
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Patent number: 8946360Abstract: The present invention relates to a process for continuously preparing polymer by RAFT solution polymerization, the process comprising: introducing into a flow reactor a reaction solution comprising one or more ethylenically unsaturated monomers, RAFT agent, non-reactive solvent and free radical initiator; and promoting RAFT polymerization of the one or more ethylenically unsaturated monomers within the reactor so as to form a polymer solution that flows out of the reactor.Type: GrantFiled: August 12, 2011Date of Patent: February 3, 2015Assignee: Commonwealth Scientific and Industrial Research OrganisationInventors: John Chiefari, Christian Hornung, Simon Saubern
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Publication number: 20140350182Abstract: The invention provides for a process for removing thiocarbonylthio groups from polymer prepared by RAFT polymerisation, the process comprising: introducing into a flow reactor a solution comprising the RAFT polymer in solvent; and promoting a reaction within the flow reactor that removes the thiocarbonylthio groups so as to form a solution that flows out of the reactor comprising the RAFT polymer absent the thiocarbonylthio groups.Type: ApplicationFiled: December 14, 2012Publication date: November 27, 2014Inventors: John Chiefari, Christian Hornung, Almar Postma, Simon Saubern
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Publication number: 20130217841Abstract: The present invention relates to a process for continuously preparing polymer by RAFT solution polymerisation, the process comprising: introducing into a flow reactor a reaction solution comprising one or more ethylenically unsaturated monomers, RAFT agent, non-reactive solvent and free radical initiator; and promoting RAFT polymerisation of the one or more ethylenically unsaturated monomers within the reactor so as to form a polymer solution that flows out of the reactor.Type: ApplicationFiled: August 12, 2011Publication date: August 22, 2013Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATIONInventors: John Chiefari, Christian Hornung, Simon Saubern
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Publication number: 20120004381Abstract: A method of preparing polymer, the method comprising polymerising one or more ethylenically unsaturated monomers of formula (I) where U is selected from H, C1-C4 alkyl or halogen; V is halogen or of the form O-G where G is selected from —C(O)R1 and —R1, or V is of the form NGGa where G is as defined above and Ga is selected from H and R1, G and Ga form together with N a heterocyclic ring, or V is of the form CH2Gb where Gb is selected from H, R1, OH, OR1, NR12, PR12, P(O)R12, P(OR1)2, SR1, SOR1, and SO2R1; and where the or each R1 is independently selected from optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl, optionally substituted alkylaryl, optionally substituted alkylheteroaryl, and an optionally substituted polymer chain, under the control of a RAType: ApplicationFiled: January 22, 2010Publication date: January 5, 2012Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATIONInventors: Ezio Rizzardo, John Chiefari, Massimo Benaglia, San Thang, Graeme Moad
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Publication number: 20060142404Abstract: The invention provides in one aspect a process for preparing a microgel by RAFT polymerizing in the presence of a RAFT chain transfer agent, one or more solvophobic monomers and one or more solvophilic monomers to form one or more block copolymers comprising one or more solvophobic blocks and one or more solvophilic blocks wherein the solvophobic block is insoluble in a dispersing medium and the solvophilic block is soluble in the dispersing medium. The block copolymer is dispersed in the dispersing medium to form micelles, which is then stabilized to form the microgel. The dispersing medium can be aqueous or lipophilic. The method of the present invention also permits one to encapsulate a wide variety of materials, such as pigments, dye molecules, and aluminum flakes used in metallized paints.Type: ApplicationFiled: April 6, 2001Publication date: June 29, 2006Inventors: Charles Berge, John Chiefari, Jeffery Johnson, Albert Mau, Roshan Mayadunne, Catherine Moad, Graeme Moad, Ezio Rizzardo, Gerry Swiegers, San Thang, Gerry Wilson
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Patent number: 7064151Abstract: The invention provides in one aspect a process for preparing a microgel by RAFT polymerizing in the presence of a RAFT chain transfer agent, one or more solvophobic monomers and one or more solvophilic monomers to form one or more block copolymers comprising one or more solvophobic blocks and one or more solvophilic blocks wherein the solvophobic block is insoluble in a dispersing medium and the solvophilic block is soluble in the dispersing medium. The block copolymer is dispersed in the dispersing medium to form micelles, which is then stabilized to form the microgel. The dispersing medium can be aqueous or lipophilic. The method of the present invention also permits one to encapsulate a wide variety of materials, such as pigments, dye molecules, and aluminum flakes used in metallized paints.Type: GrantFiled: April 6, 2001Date of Patent: June 20, 2006Assignees: E. I. du Pont de Nemours and Company, Commonwealth Scientific and Industrial Research OrganisationInventors: Charles T. Berge, John Chiefari, Jeffery W. Johnson, Albert Mau, Roshan Mayadunne, Catherine Louise Moad, Graeme Moad, Ezio Rizzardo, Gerry Swiegers, San Thang, Gerry Wilson
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Patent number: 6747111Abstract: A free radical polymerization process suitable for synthesizingpolymers is disclosed. The process utilizes novel sulfur based chain transfer agents and is widely compatible over a range of monomers and reaction conditions. Novel polymers having low pollydispersity and predictable specific polymer architecture and molecular weight are produced by the process. The polymers produced by the process are suitable for use as binders in automotive OEM and refinish coatings.Type: GrantFiled: July 18, 2003Date of Patent: June 8, 2004Assignees: E. I. du Pont de Nemours and Company, Commonwealth Scientific and Industrial Research OrganizationInventors: John Chiefari, Roshan Tyrrel Mayadunne, Graeme Moad, Ezio Rizzardo, San Hoa Thang
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Publication number: 20040024132Abstract: A free radical polymerization process suitable for synthesizingpolymers is disclosed. The process utilizes novel sulfur based chain transfer agents and is widely compatible over a range of monomers and reaction conditions. Novel polymers having low polydispersity and predictable specific polymer architecture amd molecular weight are produced by the process. The polymers produced by the process are suitable for use as binders in automotive OEM and refinish coatings.Type: ApplicationFiled: July 18, 2003Publication date: February 5, 2004Inventors: John Chiefari, Roshan Tyrrel Mayadunne, Graeme Moad, Ezio Rizzardo, San Hoa Thang
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Patent number: 6642318Abstract: A free radical polymerization process suitable for synthesizing polymers is disclosed. The process utilizes novel sulfur based chain transfer agents and is widely compatible over a range of monomers and reaction conditions. Novel polymers having low polydispersity and predictably specific polymer architecture and molecular weight are produced by the process. The polymers produced by the process are suitable for use as binders in automotive OEM and refinish coatings.Type: GrantFiled: June 16, 2000Date of Patent: November 4, 2003Assignees: E. I. du Pont de Nemours and Company, Commonwealth Scientific and Industrial Research OrganizationInventors: John Chiefari, Roshan Tyrrel Mayadunne, Graeme Moad, Ezio Rizzardo, San Hoa Thang
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Patent number: 6376626Abstract: A free-radical polymerization process for making macromonomers having the structure: comprising contacting: (a) CH2═CHY; (b) optionally, CH2═CXB; and (c) free-radicals, produced from a free-radical source; in which B, U, X, Y, Z, m, n and p are defined in the text; macromonomer quality being controlled by adjusting one or more of the following variables: molar ratios of a, b and c; temperature; monomer concentration; and conversion.Type: GrantFiled: October 19, 1999Date of Patent: April 23, 2002Assignee: Commonwealth Scientific and Industrial Research OrganizationInventors: John Chiefari, Graeme Moad, Ezio Rizzardo, Alexei A. Gridnev