Abstract: Personal care compositions, such as oral care and skin care compositions containing a flavor/perfume system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.

Abstract: An oral care composition with reduced bitterness containing polyquaternium-2, polyquaternium-17, and/or polyquaternium-18.

Abstract: TREK-1 agonist comprising composition that reduces perceived oral discomfort sensation and a method for measuring TREK-1 potassium channel activation.

Abstract: A skin engaging shaving aid member suitable for use in a shaving device, said skin engaging shaving aid member comprising a thermally resilient sensate such as N-substituted menthanecarboxamide and a TRPA1 receptor inhibitor.

Abstract: Treated surfactant composition containing a water-soluble surfactant and exhibiting improved taste, said composition comprising: a water-soluble surfactant selected from alkyl phosphate surfactants, alkyl phosphate ethoxylated surfactants, betaine surfactants, betaine ethoxylated surfactants, amine oxide surfactants, and mixtures thereof and water; wherein the composition further comprises: less than about 4%, by weight of the water-soluble surfactant, of total undesirable non-polar materials; less than about 2.5%, by weight of the water-soluble surfactant, of alcohols having a carbon chain length of greater than 4; less than about 1%, by weight of the water-soluble surfactant, of amine and amide materials; and less than about 1%, by weight of the water-soluble surfactant, undesirable non-polar materials selected from aldehydes, esters, ketones, and organic acids. Such compositions wherein the compositions have been subjected to liquid-liquid extraction processes.

Abstract: Processes for improving the taste of oral care raw materials using solvent extraction, said process comprising the steps of: providing a solid oral care raw material composition in need of treatment wherein said oral care raw material composition comprises an orally acceptable raw material and one or more undesirable non-polar materials; contacting said oral care raw material composition with an extraction solvent to form an extraction mixture comprising a solid phase and a solvent phase; and separating the solid phase from the extraction mixture; wherein the extraction solvent is selected from solvents having individual Hansen solubility parameters of a dispersion force component (?D) ranging from about 15 to about 17 (MPa)0.5, a polar component (?P) ranging from 0 to about 9 (MPa)0.5 and a hydrogen bonding component (?H) ranging from 0 to about 11 (MPa)0.5.

Abstract: A method to detect bioavailable metal ions from an oral care composition and a method to select for compounds that inhibit the uptake of metal ions into cells.

Abstract: Treated surfactant composition containing a water-soluble surfactant and exhibiting improved taste, said composition comprising: a water-soluble surfactant selected from alkyl phosphate surfactants, alkyl phosphate ethoxylated surfactants, betaine surfactants, betaine ethoxylated surfactants, amine oxide surfactants, and mixtures thereof and water; wherein the composition further comprises: less than about 4%, by weight of the water-soluble surfactant, of total undesirable non-polar materials; less than about 2.5%, by weight of the water-soluble surfactant, of alcohols having a carbon chain length of greater than 4; less than about 1%, by weight of the water-soluble surfactant, of amine and amide materials; and less than about 1%, by weight of the water-soluble surfactant, undesirable non-polar materials selected from aldehydes, esters, ketones, and organic acids. Such compositions wherein the compositions have been subjected to liquid-liquid extraction processes.

Abstract: Processes for improving the taste of oral care raw materials using solvent extraction, said process comprising the steps of: providing a solid oral care raw material composition in need of treatment wherein said oral care raw material composition comprises an orally acceptable raw material and one or more undesirable non-polar materials; contacting said oral care raw material composition with an extraction solvent to form an extraction mixture comprising a solid phase and a solvent phase; and separating the solid phase from the extraction mixture; wherein the extraction solvent is selected from solvents having individual Hansen solubility parameters of a dispersion force component (?D) ranging from about 15 to about 17 (MPa)0.5, a polar component (?P) ranging from 0 to about 9 (MPa)0.5 and a hydrogen bonding component (?H) ranging from 0 to about 11 (MPa)0.5.

Abstract: A personal care composition comprising a methyl naphthalenyl ketone or a derivative thereof, such as 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2naphthalenyl)-ethan-1-one, for down regulating at least one TRP receptor associated with a pain response, including but not limited to TRPV1 and TRPA1 receptors to reduce skin irritation associated with hair removal.

Abstract: Provided herein are compositions and methods relating to oral care compositions with improved taste. One such method includes providing an oral care composition comprising a metal salt, a peroxide, an antimicrobial agent, a bad breath reduction agent, a surfactant, or a combination thereof and adding to the oral care composition a TRPV1 activator and/or vanitrope.

Abstract: Provided herein are compositions and methods relating to oral care compositions with improved taste. One such method includes providing an oral care composition comprising a metal salt, a peroxide, an antimicrobial agent, a bad breath reduction agent, a surfactant, or a combination thereof and adding to the oral care composition a TRPV1 activator and/or vanitrope.

Abstract: The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example with an aromatic ring or aryl moiety. Such structures have high cooling potency and long lasting sensory effect, which make them useful in a wide variety of consumer products. One synthetic route involves a copper catalyzed coupling of a primary menthanecarboxamide with an aryl halide, such reaction working best in the presence of potassium phosphate and water. Using this synthetic route, specific isomers can be prepared including the menthanecarboxamide isomer having the same configuration as l-menthol and new isomers such as a neoisomer having opposite stereochemistry at the carboxamide (C-1) position. The neoisomer unexpectedly has potent and long lasting cooling effect.

Abstract: The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example with an aromatic ring or aryl moiety. Such structures have high cooling potency and long lasting sensory effect, which make them useful in a wide variety of consumer products. One synthetic route involves a copper catalyzed coupling of a primary menthanecarboxamide with an aryl halide, such reaction working best in the presence of potassium phosphate and water. Using this synthetic route, specific isomers can be prepared including the menthanecarboxamide isomer having the same configuration as l-menthol and new isomers such as a neoisomer having opposite stereochemistry at the carboxamide (C-1) position. The neoisomer unexpectedly has potent and long lasting cooling effect.

Abstract: Processes for improving the taste of water-soluble surfactants using liquid-liquid solvent extraction, said process comprising the steps of: providing a water-soluble surfactant composition in need of treatment wherein said water-soluble surfactant composition comprises a water-soluble surfactant and one or more undesirable non-polar materials; contacting said water-soluble surfactant composition with an extraction solvent and water to form an extraction mixture comprising an aqueous phase and a solvent phase; and separating the aqueous phase from the solvent phase; wherein the extraction solvent is selected from solvents having individual Hansen solubility parameters of a dispersion force component (?D) ranging from about 15 to about 17 (MPa)0.5, a polar component (?P) ranging from 0 to about 9 (MPa)0.5 and a hydrogen bonding component (?H) ranging from 0 to about 11 (MPa)0.5.

Abstract: Processes for improving the taste of water-soluble surfactants using liquid-liquid solvent extraction, said process comprising the steps of: providing a water-soluble surfactant composition in need of treatment wherein said water-soluble surfactant composition comprises a water-soluble surfactant and one or more undesirable non-polar materials; contacting said water-soluble surfactant composition with an extraction solvent and water to form an extraction mixture comprising an aqueous phase and a solvent phase; and separating the aqueous phase from the solvent phase; wherein the extraction solvent is selected from solvents having individual Hansen solubility parameters of a dispersion force component (?D) ranging from about 15 to about 17 (MPa)0.5, a polar component (?P) ranging from 0 to about 9 (MPa)0.5 and a hydrogen bonding component (?H) ranging from 0 to about 11 (MPa)0.5.

Abstract: The present invention is directed to improved sweetener compositions and oral care compositions, especially those in the form of a toothpaste or oral/dental rinse, comprising the same. The sweetener composition comprises a combination of saccharin, sucralose and a rebaudioside, or sweeteners of similar sucrose equivalence and type, preferably in a ratio of about 1:about 1: about 2. The sweetener composition of the invention was found to significantly improve the taste profile, long lasting freshness and clean feel of oral care compositions and to deliver an in-use sweetness that was more natural and pleasant than artificial sweeteners alone.

Abstract: Processes for improving the taste of oral care raw materials using solvent extraction, said process comprising the steps of: providing a solid oral care raw material composition in need of treatment wherein said oral care raw material composition comprises an orally acceptable raw material and one or more undesirable non-polar materials; contacting said oral care raw material composition with an extraction solvent to form an extraction mixture comprising a solid phase and a solvent phase; and separating the solid phase from the extraction mixture; wherein the extraction solvent is selected from solvents having individual Hansen solubility parameters of a dispersion force component (?D) ranging from about 15 to about 17 (MPa)0.5, a polar component (?P) ranging from 0 to about 9 (MPa)0.5 and a hydrogen bonding component (?H) ranging from 0 to about 11 (MPa)0.5.

Abstract: Processes for preparing an oral care composition having improved taste, color, odor and/or clarity, wherein said processes comprise the steps of: providing an unfiltered dentifrice component selected from unfiltered alkyl phosphate surfactants, alkyl phosphate ethoxylated surfactants, lauryl sulfate surfactants, betaine surfactants, antibacterial agents, cetyl pyridinium chloride, metal Salts, phytic acids, or mixtures thereof; filtering the unfiltered dentifrice component with an adsorbent to form a filtered dentifrice component; and incorporating the filtered dentifrice component into the oral care composition. In one such process, activated carbon with a median particle size of less than or equal to about 30 ?m, optionally a macro-mesoporous:microporous ratio about 0.

Abstract: The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example with an aromatic ring or aryl moiety. Such structures have high cooling potency and long lasting sensory effect, which make them useful in a wide variety of consumer products. One synthetic route involves a copper catalyzed coupling of a primary menthanecarboxamide with an aryl halide, such reaction working best in the presence of potassium phosphate and water. Using this synthetic route, specific isomers can be prepared including the menthanecarboxamide isomer having the same configuration as l-menthol and new isomers such as a neoisomer having opposite stereochemistry at the carboxamide (C-1) position. The neoisomer unexpectedly has potent and long lasting cooling effect.