Patents by Inventor John Clark Lagarias
John Clark Lagarias has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11021523Abstract: The present invention provides a protein fusion construct comprising a far-red cyanobacteriochrome (CBCR) domain linked to a heterologous domain, wherein the far-red CBCR domain comprises a CBCR polypeptide and a tetrapyrrole chromophore. The invention also provides nucleic acids, expression cassettes, vectors, and host cells for expression of the far-red CBCR protein fusion constructs. Methods for detecting cellular components, methods for imaging biological structures, and method for modulating cellular processes using the protein fusion constructs are also provided.Type: GrantFiled: August 22, 2018Date of Patent: June 1, 2021Assignee: The Regents of the University of CaliforniaInventors: John Clark Lagarias, Nathan Clarke Rockwell
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Publication number: 20190133160Abstract: Compositions and methods are disclosed for the coloring of foodstuffs with recombinant, purified, and/or isolated cyanobacteriochromes (CBCRs). The CBCRs can affect the apparent color of a food by selective absorbing or fluorescing particular wavelengths of light. The CBCRs can have either colorfast properties, in which the CBCRs consistently appear as having a single color, or color changing properties, in which the CBCRs can switch between two states that each appear as a different color.Type: ApplicationFiled: November 14, 2018Publication date: May 9, 2019Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: John Clark Lagarias, Nathan Clarke Rockwell, Shelley S. Martin
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Publication number: 20180354998Abstract: The present invention provides a protein fusion construct comprising a far-red cyanobacteriochrome (CBCR) domain linked to a heterologous domain, wherein the far-red CBCR domain comprises a CBCR polypeptide and a tetrapyrrole chromophore. The invention also provides nucleic acids, expression cassettes, vectors, and host cells for expression of the far-red CBCR protein fusion constructs. Methods for detecting cellular components, methods for imaging biological structures, and method for modulating cellular processes using the protein fusion constructs are also provided.Type: ApplicationFiled: August 22, 2018Publication date: December 13, 2018Applicant: The Regents of the University of CaliforniaInventors: John Clark Lagarias, Nathan Clarke Rockwell
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Patent number: 9506080Abstract: This invention pertains to the discovery of mutant phytochromes that when introduced into a plant alter the photomorphogenic properties of that plant. In certain embodiments transfection of plants by nucleic acid constructs expressing the mutant phytochromes produced plants having a phenotype characterized by light-independent’ activation. Thus, in certain embodiments, this invention provides a transgenic plant or plant cell comprising a mutant phytochrome where the mutant phytochrome is a light-stable phytochrome; and the transgenic plant shows decreased shade avoidance as compared to the same species or strain of plant lacking the mutant phytochrome. In various embodiments the mutant phytochrome comprises a mutation at the position corresponding to tyrosine residue 276 in an Arabidopsis phytochrome where the mutation is to a residue other than tyrosine.Type: GrantFiled: April 9, 2014Date of Patent: November 29, 2016Assignee: The Regents of the University of CaliforniaInventors: John Clark Lagarias, Yi-Shin Su
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Publication number: 20140331359Abstract: This invention pertains to the discovery of mutant phytochromes that when introduced into a plant alter the photomorphogenic properties of that plant. In certain embodiments transfection of plants by nucleic acid constructs expressing the mutant phytochromes produced plants having a phenotype characterized by light-independent’ activation. Thus, in certain embodiments, this invention provides a transgenic plant or plant cell comprising a mutant phytochrome where the mutant phytochrome is a light-stable phytochrome; and the transgenic plant shows decreased shade avoidance as compared to the same species or strain of plant lacking the mutant phytochrome. In various embodiments the mutant phytochrome comprises a mutation at the position corresponding to tyrosine residue 276 in an Arabidopsis phytochrome where the mutation is to a residue other than tyrosine.Type: ApplicationFiled: April 9, 2014Publication date: November 6, 2014Applicant: The Regents of the University of CaliforniaInventors: John Clark LAGARIAS, Yi-Shin SU
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Patent number: 8735555Abstract: This invention pertains to the discovery of mutant phytochromes that when introduced into a plant alter the photomorphogenic properties of that plant. In certain embodiments transfection of plants by nucleic acid constructs expressing the mutant phytochromes produced plants having a phenotype characterized by light-independent activation. Thus, in certain embodiments, this invention provides a transgenic plant or plant cell comprising a mutant phytochrome where the mutant phytochrome is a light-stable phytochrome; and the transgenic plant shows decreased shade avoidance as compared to the same species or strain of plant lacking the mutant phytochrome. In various embodiments the mutant phytochrome comprises a mutation at the position corresponding to tyrosine residue 276 in an Arabidopsis phytochrome where the mutation is to a residue other than tyrosine.Type: GrantFiled: April 16, 2007Date of Patent: May 27, 2014Assignee: The Regents of the University of CaliforniaInventors: John Clark Lagarias, Yi-Shin Su
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Patent number: 7795397Abstract: This invention provides fluorescent adducts that emit in the far red and/or near infrared. In certain embodiments, the adducts comprise a mutant apoprotein and a bilin.Type: GrantFiled: May 5, 2005Date of Patent: September 14, 2010Assignee: The Regents of the University of CaliforniaInventors: John Clark Lagarias, Amanda J. Fischer
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Publication number: 20090300793Abstract: This invention pertains to the discovery of mutant phytochromes that when introduced into a plant alter the photomorphogenic properties of that plant. In certain embodiments transfection of plants by nucleic acid constructs expressing the mutant phytochromes produced plants having a phenotype characterized by light-independent activation. Thus, in certain embodiments, this invention provides a transgenic plant or plant cell comprising a mutant phytochrome where the mutant phytochrome is a light-stable phytochrome; and the transgenic plant shows decreased shade avoidance as compared to the same species or strain of plant lacking the mutant phytochrome. In various embodiments the mutant phytochrome comprises a mutation at the position corresponding to tyrosine residue 276 in an Arabidopsis phytochrome where the mutation is to a residue other than tyrosine.Type: ApplicationFiled: April 16, 2007Publication date: December 3, 2009Inventors: John Clark Lagarias, Yi-Shin Su
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Patent number: 7033806Abstract: This invention identifies a novel family of bilin reductases. Designated herein HY bilin reductases, the enzymes of this invention are useful in a wide variety of contexts including but not limited to the conversion of biliverdins to phytobilins and the assembly of holophytochromes or phytofluors.Type: GrantFiled: May 29, 2001Date of Patent: April 25, 2006Assignee: The Regents of the University of CaliforniaInventors: John Clark Lagarias, Takayuki Kochi, Nicole Frankenberg, Gregory A. Gambetta, Beronda L. Montgomery
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Patent number: 6887688Abstract: This invention relates to the field of gene expression. In particular this invention relates to the use of heterologous phytochromes to translocate polypeptides into the nucleus of a cell. Where the polypeptides comprise transactivators or repressors this invention provides a system for light-directed gene expression.Type: GrantFiled: May 29, 2002Date of Patent: May 3, 2005Assignee: The Regents of the University of CaliforniaInventors: John Clark Lagarias, Takayuki Kochi, Nicole Frankenberg, Gregory A. Gambetta, Beronda L. Montgomery
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Publication number: 20030104379Abstract: This invention identifies a novel family of bilin reductases. Designated herein HY bilin reductases, the enzymes of this invention are useful in a wide variety of contexts including but not limited to the conversion of biliverdins to phytobilins and the assembly of holophytochromes or phytofluors.Type: ApplicationFiled: May 29, 2001Publication date: June 5, 2003Applicant: The Regents of the University of CaliforniaInventors: John Clark Lagarias, Takayuki Kochi, Nicole Frankenberg, Gregory A. Gambetta, Beronda L. Montgomery
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Publication number: 20030073235Abstract: This invention relates to the field of gene expression. In particular this invention relates to the use of heterologous phytochromes to translocate polypeptides into the nucleus of a cell. Where the polypeptides comprise transactivators or repressors this invention provides a system for light-directed gene expression.Type: ApplicationFiled: May 29, 2002Publication date: April 17, 2003Applicant: The Regents of the University of CaliforniaInventors: John Clark Lagarias, Takayuki Kochi, Nicole Frankenberg, Gregory A. Gambetta, Beronda L. Montgomery
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Publication number: 20020022239Abstract: This invention provides new fluorescent molecules useful for detection of target entities. In particular, it relates to fluorescent adducts comprising an apoprotein and a bilin.Type: ApplicationFiled: March 19, 1999Publication date: February 21, 2002Inventor: JOHN CLARK LAGARIAS
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Patent number: 6046014Abstract: This invention provides new fluorescent molecules useful for detection of target entities. In particular, it relates to fluorescent adducts comprising an apoprotein and a bilin.Type: GrantFiled: August 1, 1997Date of Patent: April 4, 2000Assignee: The Regents of the University of CaliforniaInventors: John Clark Lagarias, John Thomas Murphy