Abstract: Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R1, R2, R3, R4, R5 and R6 are as described herein.

Abstract: An implant includes a curved first plate section having a curvature about a longitudinal axis extending in a longitudinal direction. The first plate section has a first hole and a second hole. The first hole and the second hole are positioned to receive respective bone screws for attaching the implant to a first curved surface of a bone having a syndesmosis. A second plate section extends continuously from the first plate section. The second plate section has at least a third hole that is positioned to be offset from the first hole and the second hole in a direction that is anterior or posterior from the first hole and the second hole in a case where the longitudinal axis is aligned along a superior-inferior direction. The third hole is configured to receive at least one screw or at least one button for holding a suture at a position offset from the first line segment hole and the second hole in the anterior or posterior direction, for reducing the syndesmosis.

Abstract: A method for chemical processing of sewage sludge ash comprises dissolving a start material, emanating from sewage sludge ash, in an acid comprising hydrochloric acid. The start material comprising at least silicon and iron compounds. Undissolved residues are separated, whereby a leachate remains. The amount of colloidal silica in the dissolved sewage sludge ash is controlled. At least one of iron and phosphorus is extracted from the leachate by liquid-liquid extraction with an organic solvent. At least a part of a raffinate at least partly depleted in at least one of iron and phosphorus originating from the step of extracting at least one of iron and phosphorus is recirculated for dissolving the start material, emanating from sewage sludge ash. The recirculated part of the raffinate at least partly depleted in at least one of iron and phosphorus comprises chloride ions.

Abstract: A system for automatically monitoring efficacy of security controls in a computer network, including a probe engine configurable with at least one set of rules relating to access permissions to data in the computer network, at least one security probe forming part of the probe engine and operative to automatically place, at at least one storage location within the computer network and with access permissions that are non-compliant with the at least one set of rules, simulated data corresponding to the data in the computer network and attempt to access the simulated data following the placement thereof, using access privileges satisfying the non-compliant access permissions, and a security monitoring and reporting module operative to provide a user sensible output indicating at least whether the attempt to access the simulated data was successful and, if so, reporting mitigating activities by the security controls in response to the successful attempt.

Abstract: A storage, retrieval and processing system for processing objects is disclosed. The storage, retrieval and processing system includes a plurality of storage bins providing storage of a plurality of objects, where the plurality of storage bins is in communication with a retrieval conveyance system, a programmable motion device in communication with the retrieval conveyance system for receiving the storage bins from the plurality of bins, where the programmable motion device includes an end effector for grasping and moving a selected object out of a selected storage bin, and a movable carriage for receiving the selected object from the end effector of the programmable motion device, and for carrying the selected object to one of a plurality of destination bins.

Abstract: The present invention is directed to anti-PVRIG antibodies and stable liquid pharmaceutical formulations thereof. The present invention is directed to monotherapy and combination treatments with anti-PVRIG antibodies and anti-PD-1 antibodies, in particular nivolumab, using stable liquid pharmaceutical formulations thereof.

Abstract: The present invention is directed to anti-PVRIG antibodies and stable liquid pharmaceutical formulations thereof. The present invention is directed to monotherapy and combination treatments with anti-PVRIG antibodies and anti-PD-1 antibodies, in particular nivolumab, using stable liquid pharmaceutical formulations thereof. The present invention also provides biomarkers for use in determining populations for treatment with anti-PVRIG antibodies and such biomarkers include, for example PVRIG and/or PVRL2 expression.

Abstract: A head mountable device for detecting a functional disorder of a brain in a patient, includes: an opaque visor unit for positioning over eyes of the patient, a plurality of reference sensors adapted to detect a reference electrical potential for the patient during exposure to the visual stimulus, and a sensor housing including at least one electroencephalogram (EEG) electrode for measuring electrical potential generated by the brain of the patient. The visor unit includes an arrangement of a plurality of LEDs positioned on an inside surface of said visor unit to which, during use, the eyes of the patient are exposed, and an LED driver, said LED driver being configured to control each of said LEDs independently to display a visual stimulus.

Abstract: A temperature-regulating mattress system provides dynamic adjustment of temperature and other parameters throughout a user's sleep cycle to maximize the quality of the user's sleep, Features of the system may include: (a) heating and cooling temperature regulation (with dynamic custom profiles that control humidity and are dual-zone); (b) smart controls (with remotes and apps that learn from users to optimize settings and work with smart home products such as Alexa and interactive lighting systems); (c) comfort (with a mattress that provide the necessary support for its users); and (d) sensors used for temperature and humidity estimation algorithms, control mechanism, and additional inferences from those sensors (pose, enrichment of biometric sensing data, etc.).

Abstract: An interactive lighting system includes a group of one or more portable lamps designed to respond to user's spatial manipulation of a lamp to control the system. The lamps can be wirelessly linked to operate in unison, and each lamp could also include an ambient light sensor, which helps the system to optimize illumination characteristics and profile.

Abstract: An interactive lighting system includes a group of one or more portable lamps designed to respond to user's spatial manipulation of a lamp to control the system. The lamps can be wirelessly linked to operate in unison, and each lamp could also include an ambient light sensor, which helps the system to optimize illumination characteristics and profile.

Abstract: A head mountable device for detecting a functional disorder of the brain in a patient, comprising an LED display; at least one electrode for measuring electrical potential; the device being configured to be mountable on the head of a patient such that when mounted on the head of a patient the LED display is positioned before the eyes of a patient and the at least one electrode is positioned adjacent to the occipital lobe of the patient.

Abstract: A drilling riser system includes a plurality of interchangeable dockable modules having sealable hydraulic connections configured to connect to a module docking structure disposed in at least one specific segment of a drilling riser and to seal the hydraulic connections. Each of the interchangeable dockable modules includes at least one of an hydraulic termination or connection to an hydraulic device for each of a fluid conduit in fluid communication with the and at least one auxiliary line associated with the riser.

Abstract: A temperature-regulating mattress system provides dynamic adjustment of temperature and other parameters throughout a user's sleep cycle to maximize the quality of the user's sleep, Features of the system may include: (a) heating and cooling temperature regulation (with dynamic custom profiles that control humidity and are dual-zone); (b) smart controls (with remotes and apps that learn from users to optimize settings and work with smart home products such as Alexa and interactive lighting systems); (c) comfort (with a mattress that provide the necessary support for its users); and (d) sensors used for temperature and humidity estimation algorithms, control mechanism, and additional inferences from those sensors (pose, enrichment of biometric sensing data, etc.).

Abstract: The Christmas tree disposal bag is configured for use with a Christmas tree. The Christmas tree disposal bag is configured for use as a tree skirt and as a containment structure. The Christmas tree disposal bag is disposable such that the Christmas tree disposal bag contains the Christmas tree and unwanted decorative items in a segregated fashion during disposal. The Christmas tree disposal bag comprises the containment structure, a plurality of compartments and a zipper. The containment structure is a hollow sheeting structure. The Christmas tree is stored within the hollow interior of the containment structure. The plurality of compartments comprises a plurality of pouches used to store decorative items intended for transport and storage with the Christmas tree. The zipper is a fastener that is intended to control access into the hollow interior of the containment structure.

Abstract: An interactive lighting system includes a group of one or more portable lamps designed to respond to user's spatial manipulation of a lamp to control the system. The lamps can be wirelessly linked to operate in unison, and each lamp could also include an ambient light sensor, which helps the system to optimize illumination characteristics and profile.

Abstract: A drilling riser system includes a plurality of interchangeable dockable modules having sealable hydraulic connections configured to connect to a module docking structure disposed in at least one specific segment of a drilling riser and to seal the hydraulic connections. Each of the interchangeable dockable modules includes at least one of an hydraulic termination or connection to an hydraulic device for each of a fluid conduit in fluid communication with the and at least one auxiliary line associated with the riser.

Abstract: A system and method for assisting users of electrical extensions cords to detangle the cords as quickly and efficiently as possible. The improved extension cords features markings on regions of the cord to assist the user in locating the part or section of the cord associated with a single end.

Abstract: A method for removing a fluid influx from a subsea wellbore drilled using a pump to return fluid from the wellbore to the surface. The method includes detecting the influx when a rate of the return pump increases. Flow from the wellbore is diverted from the return pump to a choke line when the influx reaches the wellhead. A choke in the choke line is operated so that a substantially constant bottom hold pressure is maintained while drilling fluid continues to be pumped through the drill sgring. Fluid flow from the wellbore is redirected to the return pump inlet when the influx has substantially left the well.