Abstract: Novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, pharmaceutical compositions containing them, to processes for their preparation.

Abstract: Systems and methods for objective Deployment Failure risk assessments are provided, which may include fault trees. Systems and methods for the analysis of fault trees are provided as well. The risk assessments system may involve the development of a fault tree, assigning initial values and weights to the events within that fault tree, and the subsequent revision of those values and weights in an iterative fashion, including comparison to historical data. The systems for analysis may involve the assignment of well-ordered values to some events in a fault tree, and then the combination those values through the application of specialized, defined gates. The system may further involve the revision of specific gates by comparison to historical or empirical data.

Abstract: Systems, methods and devices for providing stabilization between first and second vertebrae are provided. More particularly, in one form a system includes an implant configured to be positioned in a disc space between the first and second vertebrae and a freestanding plate for engagement with extradiscal surfaces of the first and second vertebrae. The system also includes an insertion instrument with an engaging portion configured to releasably engage with the implant and the plate such that the implant and plate can be positioned together relative to the first and second vertebrae. In one aspect, an angular orientation of the implant relative to the plate is adjustable when the implant and the plate are engaged by the instrument. In this or another aspect, the implant and plate are held in a contiguous relationship when engaged by the instrument. However, different forms and applications are also envisioned.

Abstract: Novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, pharmaceutical compositions containing them, to processes for their preparation.

Abstract: Systems, methods and devices for providing stabilization between first and second vertebrae are provided. More particularly, in one form a system includes an implant configured to be positioned in a disc space between the first and second vertebrae and a freestanding plate for engagement with extradiscal surfaces of the first and second vertebrae. The system also includes an insertion instrument with an engaging portion configured to releasably engage with the implant and the plate such that the implant and plate can be positioned together relative to the first and second vertebrae. In one aspect, an angular orientation of the implant relative to the plate is adjustable when the implant and the plate are engaged by the instrument. In this or another aspect, the implant and plate are held in a contiguous relationship when engaged by the instrument. However, different forms and applications are also envisioned.

Abstract: Novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, pharmaceutical compositions containing them, to processes for their preparation.

Abstract: A methodology for grafting together adjacent bony structures is provided using an implant device having an endplate with an inner disc portion and outer ring portion spaced from the inner disc portion by a connecting wall disposed therebetween. An endplate interior surface includes a retaining structure for securing the endplate to one of the bony structures, and endplate an exterior surface has an integrally formed socket. A ball-joint rod has a longitudinally extending body and an end, and at least a portion of the ball-joint rod end is curvilinear in shape. The curvilinear ball-joint rod end is rotatably disposed in the endplate socket to fixedly interconnect the bony structures.

Abstract: A methodology for grafting together adjacent bony structures is provided using an implant device having an endplate with an inner disc portion and outer ring portion spaced from the inner disc portion by a connecting wall disposed there between. An endplate interior surface includes a retaining structure for securing the endplate to one of the bony structures, and endplate an exterior surface has an integrally formed socket. A ball-joint rod has a longitudinally extending body and an end, and at least a portion of the ball-joint rod end is curvilinear in shape. The curvilinear ball-joint rod end is rotatably disposed in the endplate socket to fixedly interconnect the bony structures.

Abstract: Apparatus and methods for reducing infrastructure failure rates. The apparatus and methods may involve reduction of data complexity. The reduction may be based on the use of nonlinear analysis to derive representative variables, which may be multi-valued. Multi-valued variables may be consolidated. A model may be developed based on the values and relationships of the derived variables. The model may be applied to assess the risk involved in a prospective infrastructure change.

Abstract: Systems, methods and devices for providing stabilization between first and second vertebrae are provided. More particularly, in one form a system includes an implant configured to be positioned in a disc space between the first and second vertebrae and a freestanding plate for engagement with extradiscal surfaces of the first and second vertebrae. The system also includes an insertion instrument with an engaging portion configured to releasably engage with the implant and the plate such that the implant and plate can be positioned together relative to the first and second vertebrae. In one aspect, an angular orientation of the implant relative to the plate is adjustable when the implant and the plate are engaged by the instrument. In this or another aspect, the implant and plate are held in a contiguous relationship when engaged by the instrument. However, different forms and applications are also envisioned.

Abstract: Systems, methods and devices for providing stabilization between first and second vertebrae are provided. More particularly, in one form a system includes an implant configured to be positioned in a disc space between the first and second vertebrae and a freestanding plate for engagement with extradiscal surfaces of the first and second vertebrae. The system also includes an insertion instrument with an engaging portion configured to releasably engage with the implant and the plate such that the implant and plate can be positioned together relative to the first and second vertebrae. In one aspect, an angular orientation of the implant relative to the plate is adjustable when the implant and the plate are engaged by the instrument. In this or another aspect, the implant and plate are held in a contiguous relationship when engaged by the instrument. However, different forms and applications are also envisioned.

Abstract: A methodology for grafting together adjacent bony structures is provided using an implant device having an endplate with an inner disc portion and outer ring portion spaced from the inner disc portion by a connecting wall disposed therebetween. An endplate interior surface includes a retaining structure for securing the endplate to one of the bony structures, and endplate an exterior surface has an integrally formed socket. A ball-joint rod has a longitudinally extending body and an end, and at least a portion of the ball-joint rod end is curvilinear in shape. The curvilinear ball-joint rod end is rotatably disposed in the endplate socket to fixedly interconnect the bony structures.

Abstract: Compounds of Formula I and methods for treating metabolic disorders are disclosed.

Abstract: Apparatus and methods for reducing infrastructure failure rates. The apparatus and methods may compile and store data related to the organizational segments associated with the approval and implementation of an infrastructure change. Variables may be derived from the data using a range of methods, and multiple variable values may be consolidated. A model may be developed based on the values and relationships of the derived variables. The model may be applied to assess the risk involved in a prospective infrastructure change.

Abstract: A methodology for grafting together adjacent bony structures is provided using an implant device having an endplate with an inner disc portion and outer ring portion spaced from the inner disc portion by a connecting wall disposed therebetween. An endplate interior surface includes a retaining structure for securing the endplate to one of the bony structures, and endplate an exterior surface has an integrally formed socket. A ball-joint rod has a longitudinally extending body and an end, and at least a portion of the ball-joint rod end is curvilinear in shape. The curvilinear ball-joint rod end is rotatably disposed in the endplate socket to fixedly interconnect the bony structures.

Abstract: A spinal fusion device for implantation between spinal vertebrae includes an implant member having an opposed upper and lower surface, an outer sidewall having an aperture having internal threads, and an inner sidewall defining a central opening. A plate member is attached to the implant member such that the plate member is perpendicular relative to the implant member and includes a plurality of angled apertures for receiving anchoring fasteners and a central aperture for receiving a locking fastener. A locking member is attached to the cage member. The locking member includes a tubular shaft having internal threads that is inserted through the aperture of the outer sidewall of the implant member. A locking fastener is inserted through the central aperture of the plate member and into the locking member to thereby lock the spinal fusion device in position.

Abstract: Systems, methods and devices for providing stabilization between first and second vertebrae are provided. More particularly, in one form a system includes an implant configured to be positioned in a disc space between the first and second vertebrae and a freestanding plate for engagement with extradiscal surfaces of the first and second vertebrae. The system also includes an insertion instrument with an engaging portion configured to releasably engage with the implant and the plate such that the implant and plate can be positioned together relative to the first and second vertebrae. In one aspect, an angular orientation of the implant relative to the plate is adjustable when the implant and the plate are engaged by the instrument. In this or another aspect, the implant and plate are held in a contiguous relationship when engaged by the instrument. However, different forms and applications are also envisioned.

Abstract: Apparatus and methods for reducing infrastructure failure rates. The apparatus and methods may compile and store data related to the physical devices and applications associated with an infrastructure change. Variables may be derived from the stored data using a range of methods and multiple variable values may be consolidated. A model may be developed based on the values and relationships of the derived variables. The model may be applied to assess the risk of a prospective infrastructure change.

Abstract: Apparatus and methods for reducing infrastructure failure rates. The apparatus and methods may compile and store data related to the physical devices and applications associated with an infrastructure change. Variables may be derived from the stored data using a range of methods and multiple variable values may be consolidated. A model may be developed based on the values and relationships of the derived variables. The model may be applied to assess the risk of a prospective infrastructure change. The risk may include an index that corresponds to the likelihood that the infrastructure change will lead to a failure. The model may predict the magnitude of a failure should the infrastructure change fail. The model may predict the expected failure impact based on the index and the failure magnitude.

Abstract: An implant and method for attaching to vertebral members with the implant including a plate and a cage. The plate is configured to be positioned against and anchored to the bodies of the vertebral members. The plate may also extend into the intervertebral space between the vertebral members. The cage extends outward from the plate and is positioned within the intervertebral space. The implant provides a low profile that is positionable between the bodies of the vertebral members and the lamina/pars/facet joint. The implant may be implanted utilizing a lateral access to the spine. The implant and method may further include just the plate without the cage.