Patents by Inventor John D. Bradley

John D. Bradley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nematode fatty acid desaturase-like sequences
    Publication number: 20030180802
    Abstract: Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.
    Type: Application
    Filed: September 13, 2002
    Publication date: September 25, 2003
    Inventors: Andrew P. Kloek, Deryck J. Williams, Merry B. McLaird, John D. Bradley, Jennifer A. Davila-Aponte, Siqun Xu, Anita M. Frevert
  • Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
    Publication number: 20030149002
    Abstract: The present invention provides therapeutic compositions containing lysophosphatidic acids, methods for making the compositions, and methods of use thereof.
    Type: Application
    Filed: October 8, 2002
    Publication date: August 7, 2003
    Applicant: SKY HIGH, LLC.
    Inventors: J. Graham Goddard, Samiul R. Umansky, John D. Bradley, Ian C. Bathurst, Matthew W. Foehr, Donald H. Picker
  • Regulated gene expression in yeast and method of use
    Patent number: 6531289
    Abstract: The invention provides novel yeast cells comprising genes whose expression can be modulated by growth in the presence or absence of metal ions, methods for making such yeast cells, and methods of using such yeast cells for determining the requirement for expression of particular genes for the growth or viability of the yeast cells. The invention also provides methods of using such yeast cells in the isolation, screening and analysis of candidate antifungal compounds.
    Type: Grant
    Filed: May 18, 2000
    Date of Patent: March 11, 2003
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: John D. Bradley, Craig M. Thompson, Jeffrey B. Moore, C. Richard Wobbe, David A. Bailey
  • Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
    Patent number: 6495532
    Abstract: The present invention provides therapeutic compositions containing lysophosphotidic acids, methods for making the compositions, and methods of using the compositions in the preservation and treatment of organs.
    Type: Grant
    Filed: February 28, 2000
    Date of Patent: December 17, 2002
    Assignee: Sky High, LLC
    Inventors: Ian C. Bathurst, Matthew W. Foehr, J. Graham Goddard, Samiul R. Umansky, John D. Bradley, Donald H. Picker
  • Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
    Publication number: 20020110608
    Abstract: The present invention is to methods of obtaining plant-derived compositions that inhibit apoptosis, the compositions obtained thereby, compositions comprising the composition, and methods of use thereof.
    Type: Application
    Filed: October 23, 2001
    Publication date: August 15, 2002
    Applicant: Sky High, LLC.
    Inventors: Ian Cyril Bathurst, John D. Bradley, L. David Tomei, Philip J. Barr
  • Regulated gene expression in yeast
    Patent number: 6365409
    Abstract: The invention provides novel yeast cells comprising genes whose expression can be modulated by growth in the presence or absence of metal ions, methods for making such yeast cells, and methods of using such yeast cells for determining the requirement for expression of particular genes for the growth or viability of the yeast cells.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: April 2, 2002
    Assignee: Anadys Pharmaceuticals, Inc
    Inventors: John D. Bradley, Craig M. Thompson, Jeffrey B. Moore, C. Richard Wobbe, Judith M. Healy, Caroline E. Donnelly
  • Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
    Patent number: 6306398
    Abstract: The present invention is to methods of obtaining plant-derived compositions that inhibit apoptosis, the compositions obtained thereby, compositions comprising the composition, and methods of use thereof.
    Type: Grant
    Filed: May 22, 1997
    Date of Patent: October 23, 2001
    Assignee: LXR Biotechnology, Inc.
    Inventors: Ian Cyril Bathurst, John D. Bradley, L. David Tomei, Philip J. Barr
  • Antifungal agents
    Patent number: 6165998
    Abstract: The present invention provides azo and stilbene compounds having the structure: wherein XY is N.dbd.N, CH.dbd.CH, (C.dbd.O)--NH or NH--(C.dbd.O); wherein Z is CR.sub.6 or N; wherein R.sub.1, R.sub.2 and R.sub.5 are independently hydrogen, halogen, NO.sub.2 or CF.sub.3 ; wherein R.sub.3 is hydrogen, halogen, CF.sub.3, aryl or heteroaryl, NO.sub.2 or OCF.sub.3 ; wherein R.sub.4 is hydrogen, halogen, CF.sub.3, aryl or heteroaryl, NO.sub.2 or linear or branched chain alkoxy; wherein R.sub.6 is hydrogen or linear or branched alkyl; wherein R.sub.7 is hydrogen, cyano, hydroxyalkyl, carboxyl, halogen, hydroxyl, formyl, NO.sub.2 or halogen; and wherein R.sub.8 is hydroxyl or substituted or unsubstituted amino; and wherein R.sub.9 and R.sub.10 are independently hydrogen, CN or hydroxyalkyl. Said compounds are useful as antifungal therapeutics, fungicides and fungistats.
    Type: Grant
    Filed: September 15, 1998
    Date of Patent: December 26, 2000
    Assignee: Scriptgen Pharmaceuticals, Inc.
    Inventors: C. Richard Wobbe, John D. Bradley, Zhe Li
  • Regulated gene expression in yeast
    Patent number: 6004779
    Abstract: The invention provides novel yeast cells comprising genes whose expression can be modulated by growth in the presence or absence of metal ions, methods for making such yeast cells, and methods of using such yeast cells for determining the requirement for expression of particular genes for the growth or viability of the yeast cells.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: December 21, 1999
    Assignee: Scriptgen Pharmaceuticals, Inc.
    Inventors: John D. Bradley, Craig M. Thompson, Jeffrey B. Moore, C. Richard Wobbe, Judith M. Healy, Caroline E. Donnelly
  • Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
    Patent number: 5759548
    Abstract: The present invention is to methods of obtaining plant-derived compositions that inhibit apoptosis, the compositions obtained thereby, compositions comprising the composition, and methods of use thereof.
    Type: Grant
    Filed: October 7, 1994
    Date of Patent: June 2, 1998
    Assignee: LXR Biotechnology Inc.
    Inventors: Ian C. Bathurst, John D. Bradley, L. David Tomei, Philip J. Barr
  • Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
    Patent number: 5635187
    Abstract: The present invention is directed to methods of obtaining plant-derived delipidated extracts that inhibit apoptosis, the extracts obtained, compositions containing said extracts and methods of using said compositions. FIG. 11 is a bar graph which illustrates a lower incidence of diarrhea in rats treated with methotrexate and fed a diet of compositions of the claimed invention as compared to controls.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 3, 1997
    Assignee: LXR Biotechnology Inc.
    Inventors: Ian C. Bathurst, John D. Bradley, L. David Tomei, Philip J. Barr
  • Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
    Patent number: 5635186
    Abstract: The present invention is to methods of obtaining plant-derived compositions that inhibit apoptosis, the compositions obtained thereby, compositions comprising the composition, and methods of use thereof.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: June 3, 1997
    Assignee: LXR Biotechnology Inc.
    Inventors: Ian C. Bathurst, John D. Bradley, L. David Tomei, Philip J. Barr
  • Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
    Patent number: 5624672
    Abstract: The present invention is directed to methods of obtaining plant-derived delipidated extracts that inhibit apoptosis, the extracts obtained, compositions containing said extracts and methods of using said compositions. The figure is a bar graph which illustrates a lower incidence of diarrhea in rats treated with methotrexate and fed a diet of compositions of the claimed invention as compared to controls.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: April 29, 1997
    Assignee: LXR Biotechnology Inc.
    Inventors: Ian C. Bathurst, John D. Bradley, L. David Tomei, Philip J. Barr
  • Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
    Patent number: 5620885
    Abstract: The present invention is to methods of obtaining plant-derived compositions that-inhibit apoptosis, the compositions obtained thereby, compositions comprising the composition, and methods of use thereof.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: April 15, 1997
    Assignee: LXR Biotechnology Inc.
    Inventors: Ian C. Bathurst, John D. Bradley, L. David Tomei, Philip J. Barr
  • Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
    Patent number: 5567425
    Abstract: The present invention is to methods of obtaining plant-derived compositions that inhibit apoptosis, the compositions obtained thereby, compositions comprising the composition, and methods of use thereof.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: October 22, 1996
    Assignee: LXR Biotechnology Inc.
    Inventors: Ian C. Bathurst, John D. Bradley, L. David Tomei, Philip J. Barr