Abstract: The invention relates to a shoulder brace for approximation of the humerus head into the shoulder joint of a person, which the shoulder brace includes a shoulder pad adapted to be positioned over the top of a shoulder of a person which he shoulder pad has a dorsal end and a ventral end, and which the shoulder pad configured to extend from the dorsal side over the top of the shoulder to the ventral side; and an adjustable armpit belt. Both ends of the adjustable armpit belt are arranged to the shoulder pad, which the adjustable armpit belt is adapted to run along the armpit opposite of the shoulder on top of which the shoulder pad is positioned; an upper arm sleeve adapted to be worn around the upper arm of a person and configured to enclose the upper arm and extend from the ventral side to the dorsal side of the upper arm; and coupling means arranged with one end to the shoulder pad and with the other end to the upper arm sleeve.

Abstract: The present invention relates to novel compounds for modulating the activity of exchange proteins directly activated by cAMP (Epacs). In particular, the present invention relates to cAMP analogues that specifically modulate the activity of Epacs. Examples of the compounds of the invention are substituted deoxyadenosine-cyclic monosphosphates. The invention further relates to pharmaceutical compositions comprising the novel compounds, and the use of the compounds in the treatment of diseases like cancer, chronic inflammation, thrombosis and/or type-2 diabetes mellitus in humans and/or animals.

Abstract: The present invention relates to novel compounds for modulating the activity of exchange proteins directly activated by cAMP (Epacs). In particular, the present invention relates to cAMP analogues that specifically modulate the activity of Epacs. The invention further relates to pharmaceutical compositions comprising the novel compounds, and the use of the compounds in the treatment of humans and/or animals.