Abstract: A system includes a neural recording device implanted in a brain, a neural processing unit configured to receive raw neural data from the neural recording device, an external sensor, an artificial sensing processing unit configured to receive raw sensor data from the external sensor, and a decoder configured to receive and combine a mixed sensory-motor representation from the neural processing unit and surrogate sensory input from the artificial sensing processing unit.

Abstract: A participant, engages in healthcare provider prescribed physical rehabilitation exercises utilizing specifically designed controllers, and these exercises are mapped to one or more video game commands. These commands are coupled with other inputs to control the video game that will be used to ensure adherence to a prescribed rehabilitation regimen. Information is gathered on the participant, in order to aid in rehabilitation.

Abstract: The secure transfer of data files between secure environments (202, 211) is disclosed. At a source environment (202) a user issues a request via a first local terminal (205J) to transmit one or more selected data files (101) to a specified recipient (211) by identifying the data files and the recipient's email address. The transmission of the data file is approved, possibly by a supervisor (208) and a copy of the selected data file is made to an encrypted storage device. An email is issued to the recipient (211) identifying the location of the selected file and a first password. The selected data file is transferred to the recipient in response to the recipient identifying the location and providing the first password. Preferably, a second one-time password is provided via an alternative mode of communication.

Abstract: The secure transfer of data files between secure environments (202, 211) is disclosed. At a source environment (202) a user issues a request via a first local terminal (205J) to transmit one or more selected data files (101) to a specified recipient (211) by identifying the data files and the recipient's email address. The transmission of the data file is approved, possibly by a supervisor (208) and a copy of the selected data file is made to an encrypted storage device. An email is issued to the recipient (211) identifying the location of the selected file and a first password. The selected data file is transferred to the recipient in response to the recipient identifying the location and providing the first password. Preferably, a second one-time password is provided via an alternative mode of communication.

Abstract: There is provided apparatus for conveying real-time medical data received from patient connected terminals within a hospital to clinician. The apparatus is characterised in that the clinicians receive data from the apparatus via mobile devices (117) located outside a hospital and the apparatus is located at the hospital collecting a plurality of data sets from a plurality of patients. The apparatus comprises a first processing system (201) for receiving native medical data from a hospital internal network and for converting the data into generic video images; a second processing system (202) for authenticating requests from mobile devices to facilitate or block external communication; and a third processing system (203) for receiving input commands from the mobile devices, encrypting the generic figure images to produce encrypted video images and for transmitting the encrypted video images to the mobile devices.

Abstract: A brain implant system consistent with embodiments of the present invention includes an electrode array having a plurality of electrodes for sensing neuron signals. A method for manufacturing the electrode array includes machining a piece of an electrically conductive substance to create a plurality of electrodes extending from a base member. Each electrode also has a corresponding base section. A nonconductive layer is provided around at least a portion of the base section of each electrode to support the plurality of electrodes. The base section of the electrodes are then cut to separate the base member from the plurality of electrodes supported by the nonconductive support layer. The present invention also includes a complete brain implant system using the above electrode array.

Abstract: A system using neurological control signals to control a device is disclosed. The system may include a sensor sensing electrical activity of a plurality of neurons over time and a vector generator generating a neural control vector from the sensed electrical activity of the plurality of neurons over time. The system may also include a control filter to which the neural control vector is applied to provide a control variable and an output device controlled by the control variable.

Abstract: Various embodiments of a biological interface system and related methods are disclosed. The system may comprise a sensor comprising a plurality of electrodes for detecting multicellular signals emanating from one or more living cells of a patient and a processing unit configured to receive the multicellular signals from the sensor and process the multicellular signals to produce a processed signal. The processing unit may be configured to transmit the processed signal to a controlled device that is configured to receive the processed signal. The system is configured to perform an integrated patient training routine to generate one or more system configuration parameters that are used by the processing unit to produce the processed signal.

Abstract: Various embodiments of a biological interface system and related methods are disclosed. The system may comprise a sensor comprising a plurality of electrodes for detecting multicellular signals emanating from one or more living cells of a patient and a processing unit configured to receive the multicellular signals from the sensor and process the multicellular signals to produce a processed signal. The processing unit may be configured to transmit the processed signal to a controlled device that is configured to receive the processed signal. The system is configured to perform an integrated patient training routine to provide a time varying stimulus to the patient and to generate one or more system configuration parameters used by the processing unit to produce the processed signal.

Abstract: Various embodiments of an ambulation and movement assist system are disclosed. For example, an ambulation system for a patient may comprise an exoskeleton device attached to the patient, an FES device at least partially implanted in the patient, and a biological interface apparatus. The biological interface apparatus comprises a sensor having a plurality of electrodes for detecting multicellular signals, a processing unit configured to receive the multicellular signals from the sensor, process the multicellular signals to produce a processed signal, and transmit the processed signal to a controlled device. At least one of the exoskeleton device and the FES device is the controlled device of the biological interface apparatus.

Abstract: Systems, methods and devices for restoring or enhancing one or more motor functions of a patient are disclosed. The system comprises a biological interface apparatus and a joint movement device such as an exoskeleton device or FES device. The biological interface apparatus includes a sensor that detects the multicellular signals and a processing unit for producing a control signal based on the multicellular signals. Data from the joint movement device is transmitted to the processing unit for determining a value of a configuration parameter of the system. Also disclosed is a joint movement device including a flexible structure for applying force to one or more patient joints, and controlled cables that produce the forces required.

Abstract: A system and method for an improved biological interface system that processes multicellular signals of a patient and controls one or more devices is disclosed. The system includes a sensor that detects the multicellular signals and a processing unit for producing the control signal based on the multicellular signals. The system may include improved communication, self-diagnostics, and surgical insertion tools.

Abstract: Various embodiments of a biological interface system and related methods are disclosed. The system may comprise a sensor comprising a plurality of electrodes for detecting multicellular signals emanating from one or more living cells of a patient and a processing unit configured to receive the multicellular signals from the sensor and process the multicellular signals to produce a processed signal. The processing unit may be configured to transmit the processed signal to a controlled device that is configured to receive the processed signal. The system is configured to perform an integrated patient training routine to generate one or more system configuration parameters that are used by the processing unit to produce the processed signal.

Abstract: The Holographic Beam Combiner, (HBC), is used to combine the output from many lasers into a single-aperture, diffraction-limited beam. The HBC is based on the storage of multiple holographic gratings in the same spatial location. By using a photopolymer material such as quinone-doped polymethyl methacrylate (PMMA) that uses a novel principle of “polymer with diffusion amplification” (PDA), it is possible to combine a large number (N) of diode lasers, with an output intensity and brightness 0.9 N times as much as those of the combined outputs of individual N lasers. The HBC will be a small, inexpensive to manufacture, and lightweight optical element. The basic idea of the HBC is to construct multiple holograms onto a recording material, with each hologram using a reference beam incident at a different angle, but keeping the object beam at a fixed position.

Abstract: Various embodiments of a biological interface system and their related methods are disclosed. A biological interface system may include a sensor including a plurality of electrodes configured to detect multicellular signals emanating from one or more living cells of a patient and a processing unit configured to receive the multicellular signals from the sensor, to process the multicellular signals to produce processed signals, and to transmit the processed signals. The system may also include a controlled device configured to receive the processed signals from the processing unit. The processing unit may include a processing unit first portion and a processing unit second portion, where the processing unit first portion is implanted under the scalp on the skull of the patient, and the processing unit second portion is placed above the scalp of the patient at a location proximal to the processing unit first portion.

Abstract: Various embodiments of a biological interface system and their related methods are disclosed. A biological interface system may include a sensor including a plurality of electrodes configured to detect multicellular signals emanating from one or more living cells of a patient and a processing unit configured to receive the multicellular signals from the sensor and to process the multicellular signals to produce processed signals. The system may also include a plurality of controlled devices each configured to receive the processed signals. The plurality of controlled devices include at least a first controlled device and a second controlled device. The system may include a selector module usable by an operator and being configured to select which of the first and second controlled devices is to be controlled by the processed signals.

Abstract: Systems and methods for detecting, monitoring, and/or treating neurological events based on, for example, electrical signals generated from the patient's body are disclosed. Various embodiments of the invention include a system for predicting occurrence of a neurological event in a patient's body. The system may include an implant configured to be placed in the body and detect signals indicative of an activity that precedes the neurological event, and a processing unit configured to process the detected signals so as to predict the neurological event prior to the occurrence.

Abstract: A system and method for a neural interface system with integral calibration elements may include a sensor including a plurality of electrodes to detect multicellular signals, an interface to process the signals from the sensor into a suitable control signal for a controllable device, such as a computer or prosthetic limb, and an integrated calibration routine to efficiently create calibration output parameters used to generate the control signal. A graphical user interface may be used to make various portions of the calibration and signal processing configuration more efficient and effective.

Abstract: Systems and methods are disclosed for detecting neural, biological, or other electrical signals generated within a patient's body and processing those signals to generate a control signal that may control the delivery of a biologic, therapeutic, or other agent, such as a drug. Embodiments include a system having a sensor implanted in a patient's brain to detect neural signals used to control delivery of a drug to the patient. The system may also control an internal and/or external device, such as a prosthetic limb, and control delivery of a drug to increase the performance of the system and/or the controlled device.

Abstract: Methods for making articulate detergents are disclosed. The detergent particulates are formed from a combination of pre-formed detergent particulates and other detergent ingredients may also be preformed such as blown powders, extrudates or agglomerates or particulate raw materials. Selection of the feed streams into a low or moderate shear mixing process enable of the finished detergent particle to be controlled without requiring careful control of the conditions.