Abstract: A reference generator system can include a PTAT circuit coupled to a signal supply node and configured to provide a voltage reference signal or a current reference signal that is based on a physical characteristic of one or more components of the PTAT circuit and a correction signal. The system can include a CTAT circuit coupled to the PTAT circuit and configured to provide the correction signal to the PTAT circuit. In an example, the reference generator system can be implemented at least in part using NMOS devices that comprise a portion of an indium gallium zinc oxide (IGZO) substrate.

Abstract: The present disclosure relates to a configurable output stage for a DAC channel. The output stage receives an analog output from a DAC and outputs a signal to an output terminal. The output stage is configurable between a voltage mode and a current mode. In the voltage mode, the output stage supplies the analog signal to the output terminal as a voltage signal. In the current mode, the output stage supplies the analog signal to the output signal as a current signal. The output stage can receive user input to select the desired mode. Consequently, an integrated circuit can be implemented with multiple DAC channels, each having the configurable output stage. A user can choose how many channels they want to operate in a voltage output mode, and how many channels they want to operate in a current output mode, depending on their individual requirements.

Abstract: The present disclosure relates to an integrated circuit with at least a first channel and a second channel. Each channel includes at least a DAC. The integrated circuit also includes a number of circuit elements interconnected between the channels. The circuit elements can be changed between a short circuit state and an open circuit state. Normally, each channel will operate independently of one another, using only the circuit components in its respective channel. However, the circuit elements are arranged to allow a user to combine part of the second channel with the first channel to improve the functionality and performance of the first channel. In particular, a state of the circuit elements can be chosen to combine components of the second channel with the first channel. For example, components (e.g. a sub-stage) of the second channel can be connected in parallel with corresponding components (e.g. a corresponding sub-stage) of the first channel.

Abstract: A predictive model is described that can predict parameter concentrations in the future based on initial, measured concentrations and historical data. A plurality of multivariate techniques can be used to construct the predictive model capable of forecasting concentrations over multiple and diverse cell lines. The predictive model is also scalable. In one embodiment, a future lactate concentration trajectory is determined and at least one condition within a bioreactor is changed or modified to maintain lactate concentration within desired ranges.

Abstract: A predictive model is described that can predict parameter concentrations in the future based on initial, measured concentrations and historical data. A plurality of multivariate techniques can be used to construct the predictive model capable of forecasting concentrations over multiple and diverse cell lines. The predictive model is also scalable. In one embodiment, a future lactate concentration trajectory is determined and at least one condition within a bioreactor is changed or modified to maintain lactate concentration within desired ranges.

Abstract: A process and system for efficiently producing reference data that can be fed into a predictive model for predicting quality attribute concentrations in cell culture processes. A perfusion bioreactor is operated at pseudo-steady-state conditions and one or more attribute influencing parameters are manipulated and changed over time. As the one or more attribute influencing parameters are manipulated, one or more quality attributes are monitored and measured. In one embodiment, multiple quality attributes are monitored and measured in parallel. The quality attribute information is recorded in conjunction with the changes in the attribute influencing parameters. This information is then fed to the predictive model for propagating cell cultures in commercial processes and maintaining the cell cultures within desired preset limits.

Abstract: A process and system for producing an inoculum for downstream cell production is disclosed. The inoculum is produced in a perfusion bioreactor in which the nutrient media feed is increased as the biomass concentration increases within the bioreactor. A biomass sensor can be used to periodically or continuously monitor biomass concentration. This information can be fed to a controller for automatically increasing nutrient media feed rates in a manner that is directly proportional to producing an inoculum with an increase cell density. The process and system can also include an automated subsystem for maintaining constant volume levels within the perfusion bioreactor during the process.

Abstract: Systems and methods providing, by a third party, input form fields for sensitive data on a web page provided by an organization. A user may request a web page from an organization, such as a merchant's checkout web page, that requires entry of sensitive data. The merchant's checkout web page may include reference to a script file that provides hosted sensitive data form fields. In response to rendering the merchant web page in a web browser of the user, a request to provide sensitive data form fields on the merchant web page may be received. The request may include a call to a function in a scripting file provided by the third party, and the provided file may cause one or more inline frames to be rendered in the web browser, each inline frame including a sensitive data form field. Data entered by the user in the sensitive data form fields may be received by a third party payment processor device.

Abstract: A Multi-I/O SPI for precision converters supports a Dual/Quad/Octal SPI to support the speed requirements for digital transmission and also includes a special mode that can be enabled by hardware and/or software to remove the bit scrambling requirement dictated by the JEDEC standard. The special mode removes the scramble requirement and associates each of the bidirectional data lines to a specific channel. The special mode provides backward compatibility that permits the precision converter to be used with controllers that do not natively support the JEDEC standard. Also, the Multi-I/O SPI includes registers divided into a primary region that is accessed only in default mode at power-up for write and/or read operations, and a secondary region that is accessed by any mode enabled in the control register. By restricting access to the “control” register area to a pre-defined mode in the converter at power-up, the access mode can be controlled.

Abstract: Systems and methods are disclosed for permitting users to select and implement data management services. Systems and methods receive a user selection from a user interface representation of a cloud marketplace. The user selection can include a use case specific instruction relating to the user selection representing a particular one of the plurality of cloud-enabled services. Systems and methods obtain service set up data from the user corresponding to particular aspects of the user selection. Based on the received user selection and the service set up data, a computer-executable file is created for a user identified computer, where the computer executable file, upon execution on the user identified computer, establishes a data path between a user data location and a cloud-enabled service corresponding to the user selection. Following commencement of the cloud-enabled service, the system and method provide data including usage and billing to users, cloud-enabled service providers and marketplaces.

Abstract: A reference generator system can include a PTAT circuit coupled to a signal supply node and configured to provide a voltage reference signal or a current reference signal that is based on a physical characteristic of one or more components of the PTAT circuit and a correction signal. The system can include a CTAT circuit coupled to the PTAT circuit and configured to provide the correction signal to the PTAT circuit. In an example, the reference generator system can be implemented at least in part using NMOS devices that comprise a portion of an indium gallium zinc oxide (IGZO) substrate.

Abstract: A Multi-I/O SPI for precision converters supports a Dual/Quad/Octal SPI to support the speed requirements for digital transmission and also includes a special mode that can be enabled by hardware and/or software to remove the bit scrambling requirement dictated by the JEDEC standard. The special mode removes the scramble requirement and associates each of the bidirectional data lines to a specific channel. The special mode provides backward compatibility that permits the precision converter to be used with controllers that do not natively support the JEDEC standard. Also, the Multi-I/O SPI includes registers divided into a primary region that is accessed only in default mode at power-up for write and/or read operations, and a secondary region that is accessed by any mode enabled in the control register. By restricting access to the “control” register area to a pre-defined mode in the converter at power-up, the access mode can be controlled.

Abstract: A predictive model is described that can predict parameter concentrations in the future based on initial, measured concentrations and historical data. A plurality of multivariate techniques can be used to construct the predictive model capable of forecasting concentrations over multiple and diverse cell lines. The predictive model is also scalable. In one embodiment, a future lactate concentration trajectory is determined and at least one condition within a bioreactor is changed or modified to maintain lactate concentration within desired ranges.

Abstract: Digital to analog converter architectures are disclosed that enable the binary scaling of transistor sized to be replaced by transistors of substantially the same size. This significantly reduced the size of the Digital to Analog converter on a wafer. As the currents from the lesser bits of the converter may be very small indeed, some of the transistors are operated in a regime where the gate-source voltage applied to the transistor is below the threshold voltage for the device, the threshold voltage generally being regarded as marking the onset of significant conduction through a field effect transistor.

Abstract: A process and system for efficiently producing reference data that can be fed into a predictive model for predicting quality attribute concentrations in cell culture processes. A perfusion bioreactor is operated at pseudo-steady-state conditions and one or more attribute influencing parameters are manipulated and changed over time. As the one or more attribute influencing parameters are manipulated, one or more quality attributes are monitored and measured. In one embodiment, multiple quality attributes are monitored and measured in parallel. The quality attribute information is recorded in conjunction with the changes in the attribute influencing parameters. This information is then fed to the predictive model for propagating cell cultures in commercial processes and maintaining the cell cultures within desired preset limits.

Abstract: Systems and methods providing, by a third party, input form fields for sensitive data on a web page provided by an organization. A user may request a web page from an organization, such as a merchant's checkout web page, that requires entry of sensitive data. The merchant's checkout web page may include reference to a script file that provides hosted sensitive data form fields. In response to rendering the merchant web page in a web browser of the user, a request to provide sensitive data form fields on the merchant web page may be received. The request may include a call to a function in a scripting file provided by the third party, and the provided file may cause one or more inline frames to be rendered in the web browser, each inline frame including a sensitive data form field. Data entered by the user in the sensitive data form fields may be received by a third party payment processor device.

Abstract: Digital to analog converter architectures are disclosed that enable the binary scaling of transistor sized to be replaced by transistors of substantially the same size. This significantly reduced the size of the Digital to Analog converter on a wafer. As the currents from the lesser bits of the converter may be very small indeed, some of the transistors are operated in a regime where the gate-source voltage applied to the transistor is below the threshold voltage for the device, the threshold voltage generally being regarded as marking the onset of significant conduction through a field effect transistor.

Abstract: Systems and methods providing, by a third party, input form fields for sensitive data on a web page provided by an organization. A user may request a web page from an organization, such as a merchant's checkout web page, that requires entry of sensitive data. The merchant's checkout web page may include reference to a script file that provides hosted sensitive data form fields. In response to rendering the merchant web page in a web browser of the user, a request to provide sensitive data form fields on the merchant web page may be received. The request may include a call to a function in a scripting file provided by the third party, and the provided file may cause one or more inline frames to be rendered in the web browser, each inline frame including a sensitive data form field. Data entered by the user in the sensitive data form fields may be received by a third party payment processor device.

Abstract: Systems and methods providing, by a third party, input form fields for sensitive data on a web page provided by an organization. A user may request a web page from an organization, such as a merchant's checkout web page, that requires entry of sensitive data. The merchant's checkout web page may include reference to a script file that provides hosted sensitive data form fields. In response to rendering the merchant web page in a web browser of the user, a request to provide sensitive data form fields on the merchant web page may be received. The request may include a call to a function in a scripting file provided by the third party, and the provided file may cause one or more inline frames to be rendered in the web browser, each inline frame including a sensitive data form field. Data entered by the user in the sensitive data form fields may be received by a third party payment processor device.