Abstract: This invention relates to the use of combinations of stereoisomers of dihydrotetrabenazine for the treatment of movement disorders, such as Tourette's syndrome.

Abstract: This invention relates to pharmaceutical compositions containing (+)-?-dihydrotetrabenazine and their therapeutic uses, in particular in their use in the treatment of movement disorders, such as Tourette's syndrome.

Abstract: The invention relates to pharmaceutical compositions containing both (+)-?-dihydrotetrabenazine and (?)-?-dihydrotetrabenazine and their therapeutic uses, for example in the treatment of movement disorders, such as Tourette's syndrome.

Abstract: This invention relates to the use of low doses of (+)-?-dihydrotetrabenazine for the treatment of movement disorders, such as Tourette's syndrome.

Abstract: The invention provides (+)-?-dihydrotetrabenazine succinate salt. Also provided are (+)-?-dihydrotetrabenazine succinate salt for use in medicine, pharmaceutical compositions comprising (+)-?-dihydrotetrabenazine succinate salt and a pharmaceutically acceptable excipient and the uses of (+)-?-dihydrotetrabenazine succinate salt as a VMAT2 receptor antagonist and in the treatment of a movement disorder such as Tourette's syndrome. The invention further provides a method for preparing the (+)-?-dihydrotetrabenazine succinate salt.

Abstract: An assembly adapted to evaporate a volatile fluid having a device and a refill which are detachable from one another: the device includes a magnetic induction coil configured to operate with an alternating current passed therethrough at a frequency of between substantially 20 KHz to substantially 500 KHz and a volatile fluid transport part receiving area containing at least one piece of heat-conducting, non-magnetic metal foil and/or deposited heat-conducting, non-magnetic metal; and the refill includes a reservoir for the volatile fluid, a volatile fluid transport part to draw the fluid from the reservoir, and at least one magnetic susceptor having a coercivity of substantially 50 ampere/meter (HC) to substantially 1500 ampere/meter (HC).

Abstract: Various embodiments concern inkjet printing systems designed for multilayer imaging with a high-gloss clear ink layer. More specifically, the inkjet printing systems are designed so that clear, curable inks are provided additional time to level out before being cured. The settling process enables the inkjet printing systems to produce multilayer images having high gloss values. For example, a bracket could be attached to a curing assembly that prevents radiation from striking a certain portion of the substrate onto which clear ink has recently been deposited. As another example, an inactive array of light-emitting diodes may be disposed in line with the print head(s) responsible for depositing clear ink. Moreover, various embodiments also allow for true multilayer printing of a color coat and a high-gloss clear coat in a single step (e.g., by arranging print heads into rows within a printer carriage).

Abstract: Enhanced printing solutions are enabled by providing ultraviolet curing conditions without requiring complete evacuation of atmospheric oxygen. Increased ink coverage and adjusted surface appearance are also provided.

Abstract: The uniformity of performance of inkjet nozzles within a print head containing a plurality of said nozzles is optimized by characterizing one or more performance attributes of the nozzles within said print head. A waveform set is generated that comprises a plurality of waveforms to compensate for variations of the one or more performance attributes among the nozzles. One of the waveforms within the waveform set is assigned to each nozzle to optimize the one or more performance attributes of each nozzle relative to each other nozzle in the print head. Based upon the waveform assigned to each nozzle, each nozzle in the print head responds substantially uniformly relative to each other nozzle in the print head.

Abstract: The uniformity of performance of inkjet nozzles within a print head containing a plurality of said nozzles is optimized by characterizing one or more performance attributes of the nozzles within said print head. A waveform set is generated that comprises a plurality of waveforms to compensate for variations of the one or more performance attributes among the nozzles. One of the waveforms within the waveform set is assigned to each nozzle to optimize the one or more performance attributes of each nozzle relative to each other nozzle in the print head. Based upon the waveform assigned to each nozzle, each nozzle in the print head responds substantially uniformly relative to each other nozzle in the print head.

Abstract: A combining arrangement comprises a power combiner having at least four ports. A first match-dependent oscillator is connected to input power at a first frequency to a first input port of the power combiner. A second match-dependent oscillator is connected to input power at a second frequency to a second input port of the power combiner. A mismatch is connected to a third port of the power combiner. The power combiner is operative to combine power from the first and second oscillators and, when the first and second frequencies are different, to apply a fraction of the combined power to the mismatch. The mismatch reflects at least some of the fraction of the combined power to the first and second oscillators to phase and frequency lock their outputs. A fourth output port of the power combiner is connected to receive the combined power.

Abstract: Various embodiments concern inkjet printing systems designed for multilayer imaging with a high-gloss clear ink layer. More specifically, the inkjet printing systems are designed so that clear, curable inks are provided additional time to level out before being cured. The settling process enables the inkjet printing systems to produce multilayer images having high gloss values. For example, a bracket could be attached to a curing assembly that prevents radiation from striking a certain portion of the substrate onto which clear ink has recently been deposited. As another example, an inactive array of light-emitting diodes may be disposed in line with the print head(s) responsible for depositing clear ink. Moreover, various embodiments also allow for true multilayer printing of a color coat and a high-gloss clear coat in a single step (e.g., by arranging print heads into rows within a printer carriage).

Abstract: A device for cleaning a surface comprises a pressurized container containing a cleaning composition; a nozzle through which the composition is arranged to be dispensed, in use, upon an actuation of a valve; a shroud attached to the container and surrounding the nozzle. The shroud has a hollow generally cylindrical portion adjacent to the nozzle for guiding the dispensed product in the direction in which it leaves the nozzle, and a flared portion at the end of the cylindrical portion furthest from the nozzle forming a spreading plate for guiding the dispensed product laterally when in contact, in use, with a surface to be cleaned. The nozzle is arranged to be actuated by movement of the container towards the shroud. The device comprises a reservoir. The nozzle and shroud are configured so that, in use, the cleaning composition is directed across the surface to be cleaned and into the reservoir.

Abstract: The present invention provides for a pharmaceutical composition that includes tetrabenazine and a release-retarding agent; and a method of treating a hyperkinetic movement disorder (e.g., Huntington's disease, chorea associated with Huntington's disease, hemiballismus, senile chorea, tic disorders, tardive dyskinesia, myoclonus, dystonia and/or Tourette's syndrome). The method includes administering an effective amount of the pharmaceutical composition, for a period of time effective to treat the hyperkinetic movement disorder.

Abstract: Gloss is controlled in UV ink jet printing within a printing system. Controlled pinning energy is used to adjust the amount of ink interaction between drops, substrate, and ink layers, resulting in virtual elimination of gloss banding and control of the finished gloss level from a gloss level of approximately 85 to a gloss level of approximately 5.

Abstract: Systems and methods of automatically bleeding air from a primary ink delivery system, so little or no air is mixed with the ink once it reaches a secondary ink system containing print heads. An air bleeder return assembly with a flow restrictor orifice that is configured to remove air from ink pumped to the carriage of print heads, thereby minimizing jet dropouts. Additionally, this setup provides the added advantage of the ability to run the bulk bags dry without ingesting large quantities of air to the ink delivery system.

Abstract: The present invention provides for a pharmaceutical composition that includes tetrabenazine and a release-retarding agent; and a method of treating a hyperkinetic movement disorder (e.g., Huntington's disease, chorea associated with Huntington's disease, hemiballismus, senile chorea, tic disorders, tardive dyskinesia, myoclonus, dystonia and/or Tourette's syndrome). The method includes administering an effective amount of the pharmaceutical composition, for a period of time effective to treat the hyperkinetic movement disorder.

Abstract: Systems and methods of automatically bleeding air from a primary ink delivery system, so little or no air is mixed with the ink once it reaches a secondary ink system containing print heads. An air bleeder return assembly with a flow restrictor orifice that is configured to remove air from ink pumped to the carriage of print heads, thereby minimizing jet dropouts. Additionally, this setup provides the added advantage of the ability to run the bulk bags dry without ingesting large quantities of air to the ink delivery system.

Abstract: Improved output quality of a printer used in UV curable ink jet printing is achieved by minimizing or eliminating a print artifact referred to as gloss banding or tire tracking. A same or a similar number of nozzles as used in conventional printers is used to achieve a desired throughput, but the nozzles are arranged so that any given square inch of substrate to which ink is being applied receives a lower amount of ink. A longer effective print head is provided by arranging the print heads into a longer array, where the print heads are butted substantially end-to-end. As a result, the net throughput of the printer is the same as that of a conventional printer because the printer uses the same number of print heads, but the amount of ink that is applied to any given square inch is less on a pass.

Abstract: A device for cleaning a surface comprises a pressurized container containing a cleaning composition; a nozzle through which the composition is arranged to be dispensed, in use, upon an actuation of a valve; a shroud attached to the container and surrounding the nozzle. The shroud has a hollow generally cylindrical portion adjacent to the nozzle for guiding the dispensed product in the direction in which it leaves the nozzle, and a flared portion at the end of the cylindrical portion furthest from the nozzle forming a spreading plate for guiding the dispensed product laterally when in contact, in use, with a surface to be cleaned. The nozzle is arranged to be actuated by movement of the container towards the shroud. The device comprises a reservoir. The nozzle and shroud are configured so that, in use, the cleaning composition is directed across the surface to be cleaned and into the reservoir.