Abstract: The present invention relates to powder-layer three-dimensional printers (2) having a discrete supply hopper (340) and a recoater (20). The discrete supply hopper (340) is configured to transfer a build powder to the recoater (20) in a manner that enhances the uniformity of build powder layers that are dispensed from the recoater (20). In some embodiments, at least one of the discrete supply hopper and the powder hopper of the recoater is adapted to selectively contact the other, seal against the other, and/or have one partially inserted inside the other so as to diminish or prevent powder pluming during the transfer of build powder from the discrete supply hopper to the recoater.

Abstract: An integrated active control system includes gaming devices, a server, and a network connecting the server and gaming devices. The gaming devices include gaming terminals and gaming tables. The integrated active control system aggregates gaming transaction information from the gaming devices and determines, for example, the effectiveness of the gaming establishment's floor configuration. Based on this effectiveness determination, at least one of the gaming devices are instructed to change their configuration. Staffing information may also be considered and reconfigured. The integrated active control system further monitors and configures gaming chips. The gaming chips are programmable, and may store monetary chip value and chip identification information. The programmable gaming chips are monitored for tracking the wagers made with the chips as well as for detecting their location.

Abstract: Described herein are nucleic acid detection compositions and systems comprising an internal nuclease chain reaction (NCR) for signal amplification and methods of using these NCR-containing compositions and systems.

Abstract: A nozzle assembly includes a nozzle, a manifold, and wand body. The nozzle, manifold, and wand body can be coupled together to provide a robust spray drying system that can withstand elevated temperature and/or pressure feed stock. In some embodiments, an internal shoulder portion of the manifold can engage with a side of a nozzle collar to restrict distal movement of the nozzle relative to the manifold.

Abstract: Provided, in part, are an anti-human transferrin receptor antigen-binding proteins and fusion proteins comprising an anti-human transferrin receptor antigen-binding proteins (e.g., in scFv, Fab or antibody format) which may be fused to a payload for delivery of the payload to a targeted tissue (e.g., past the blood-brain barrier and to the brain). Payloads include, for example, alpha-glucosidase (GAA) polypeptide. Methods for treating various diseases with such molecules, e.g., glycogen storage diseases, such as Pompe Disease, with the fusions are provided.

Abstract: Nucleic acid constructs and compositions that allow insertion of a multidomain therapeutic protein (e.g., GAA fusion protein) coding sequence into a target genomic locus such as an endogenous ALB locus and/or expression of the multidomain therapeutic protein (e.g., GAA fusion protein) coding sequence are also provided. The nucleic acid constructs and compositions can be used in methods of integration of a multidomain therapeutic protein (e.g., GAA fusion protein) nucleic acid into a target genomic locus, methods of expression of a multidomain therapeutic protein (e.g., GAA fusion protein) in a cell, methods of reducing glycogen accumulation, methods of treating Pompe disease or GAA deficiency in a subject, and method of preventing or reducing the onset of a sign or symptom of Pompe disease in a subject, including neonatal cells and subjects.

Abstract: A nozzle assembly includes a nozzle, a manifold, and wand body. The nozzle, manifold, and wand body can be coupled together to provide a robust spray drying system that can withstand elevated temperature and/or pressure feed stock. In some embodiments, an internal shoulder portion of the manifold can engage with a side of a nozzle collar to restrict distal movement of the nozzle relative to the manifold.

Abstract: The present system provides an enclosure which engages a blender base via friction fit created by one or more engagement members, so that a rotation of the enclosure and blender base relative to one another secures the enclosure to the blender base with an audible or tactile confirmation. A centering pad is attached to the system. The centering pad prevents the enclosure from rotating and becoming unlocked from the blender base due to operation of a motor.

Abstract: The present system provides an enclosure which engages a blender base via friction fit created by one or more engagement members, so that a rotation of the enclosure and blender base relative to one another secures the enclosure to the blender base with an audible or tactile confirmation. A centering pad is attached to the system. The centering pad prevents the enclosure from rotating and becoming unlocked from the blender base due to operation of a motor.

Abstract: The present system provides an enclosure which engages a blender base via friction fit created by one or more engagement members, so that a rotation of the enclosure and blender base relative to one another secures the enclosure to the blender base with an audible or tactile confirmation. A centering pad is attached to the system. The centering pad prevents the enclosure from rotating and becoming unlocked from the blender base due to operation of a motor.

Abstract: A beverage container having a slidably openable lid assembly is disclosed. The lid assembly basically comprises a base member and a cover member. The base member includes a wall portion releasably securing the lid assembly to the container and an opening in fluid communication with a beverage holding chamber in the container. The cover member is slidably coupled to the base member to slide from a closed position to an open position and vice versa. When the cover member is in the closed position it isolates the opening and the contiguous portions of the base member from the ambient surroundings. When the cover member is in the open position it exposes the opening to enable a user to drink the beverage via the opening. The cover includes an elastomeric member arranged to engage and seal the opening in the base member when the cover member is in the closed position.

Abstract: A beverage container having a slidably openable lid assembly is disclosed. The lid assembly basically comprises a base member and a cover member. The base member includes a wall portion releasably securing the lid assembly to the container and an opening in fluid communication with a beverage holding chamber in the container. The cover member is slidably coupled to the base member to slide from a closed position to an open position and vice versa. When the cover member is in the closed position it isolates the opening and the contiguous portions of the base member from the ambient surroundings. When the cover member is in the open position it exposes the opening to enable a user to drink the beverage via the opening. The cover includes an elastomeric member arranged to engage and seal the opening in the base member when the cover member is in the closed position.

Abstract: The present invention describes a system and method for communicating voice and data over a packet-switched network that is adapted to coexist and communicate with a legacy PSTN. The system permits packet switching of voice calls and data calls through a data network from and to any of a LEC, a customer facility or a direct IP connection on the data network. The system includes soft switch sites, gateway sites, a data network, a provisioning component, a network event component and a network management component. The system interfaces with customer facilities (e.g., a PBX), carrier facilities (e.g., a LEC) and legacy signaling networks (e.g., SS7) to handle calls between any combination of on-network and off-network callers.

Abstract: The present invention describes a system and method for communicating voice and data over a packet-switched network that is adapted to coexist and communicate with a legacy PSTN. The system permits packet switching of voice calls and data calls through a data network from and to any of a LEC, a customer facility or a direct IP connection on the data network. The system includes soft switch sites, gateway sites, a data network, a provisioning component, a network event component and a network management component. The system interfaces with customer facilities (e.g., a PBX), carrier facilities (e.g., a LEC) and legacy signaling networks (e.g., SS7) to handle calls between any combination of on-network and off-network callers.

Abstract: A beverage container having a slidably openable lid assembly is disclosed. The lid assembly basically comprises a base member and a cover member. The base member includes a wall portion releasably securing the lid assembly to the container and an opening in fluid communication with a beverage holding chamber in the container. The cover member is slidably coupled to the base member to slide from a closed position to an open position and vice versa. When the cover member is in the closed position it isolates the opening and the contiguous portions of the base member from the ambient surroundings. When the cover member is in the open position it exposes the opening to enable a user to drink the beverage via the opening. The cover includes an elastomeric member arranged to engage and seal the opening in the base member when the cover member is in the closed position.

Abstract: The present invention describes a system and method for communicating voice and data over a packet-switched network that is adapted to coexist and communicate with a legacy PSTN. The system permits packet switching of voice calls and data calls through a data network from and to any of a LEC, a customer facility or a direct IP connection on the data network. The system includes soft switch sites, gateway sites, a data network, a provisioning component, a network event component and a network management component. The system interfaces with customer facilities (e.g., a PBX), carrier facilities (e.g., a LEC) and legacy signaling networks (e.g., SS7) to handle calls between any combination of on-network and off-network callers.

Abstract: The present invention describes a system and method for communicating voice and data over a packet-switched network that is adapted to coexist and communicate with a legacy PSTN. The system permits packet switching of voice calls and data calls through a data network from and to any of a LEC, a customer facility or a direct IP connection on the data network. The system includes soft switch sites, gateway sites, a data network, a provisioning component, a network event component and a network management component. The system interfaces with customer facilities (e.g., a PBX), carrier facilities (e.g., a LEC) and legacy signaling networks (e.g., SS7) to handle calls between any combination of on-network and off-network callers.

Abstract: The present invention describes a system and method for communicating voice and data over a packet-switched network that is adapted to coexist and communicate with a legacy PSTN. The system permits packet switching of voice calls and data calls through a data network from and to any of a LEC, a customer facility or a direct IP connection on the data network. The system includes soft switch sites, gateway sites, a data network, a provisioning component, a network event component and a network management component. The system interfaces with customer facilities (e.g., a PBX), carrier facilities (e.g., a LEC) and legacy signaling networks (e.g., SS7) to handle calls between any combination of on-network and off-network callers. The soft switch sites provide the core call processing for the voice network architecture. The soft switch sites manage the gateway sites in a preferred embodiment, using a protocol such as the Internet Protocol Device Control (IPDC) protocol to request the set-up and tear-down of calls.

Abstract: The present invention describes a system and method for communicating voice and data over a packet-switched network that is adapted to coexist and communicate with a legacy PSTN. The system permits packet switching of voice calls and data calls through a data network from and to any of a LEC, a customer facility or a direct IP connection on the data network. The system includes soft switch sites, gateway sites, a data network, a provisioning component, a network event component and a network management component. The system interfaces with customer facilities (e.g., a PBX), carrier facilities (e.g., a LEC) and legacy signaling networks (e.g., SS7) to handle calls between any combination of on-network and off-network callers. The soft switch sites provide the core call processing for the voice network architecture. The soft switch sites manage the gateway sites in a preferred embodiment, using a protocol such as the Internet Protocol Device Control (IPDC) protocol to request the set-up and tear-down of calls.

Abstract: The present invention describes a system and method for communicating voice and data over a packet-switched network that is adapted to coexist and communicate with a legacy PSTN. The system permits packet switching of voice calls and data calls through a data network from and to any of a LEC, a customer facility or a direct IP connection on the data network. The system includes soft switch sites, gateway sites, a data network, a provisioning component, a network event component and a network management component. The system interfaces with customer facilities (e.g., a PBX), carrier facilities (e.g., a LEC) and legacy signaling networks (e.g., SS7) to handle calls between any combination of on- network and off-network callers. The soft switch sites provide the core call processing for the voice network architecture. The soft switch sites manage the gateway sites in a preferred embodiment, using a protocol such as the Internet Protocol Device Control (IPDC) protocol to request the set-up and tear-down of calls.