Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A method for removing contaminants from an aqueous process stream containing ammonium ions and phenol-formaldehyde resin, such as the process stream of a fiberglass insulation manufacturer. One aspect of the method includes mixing sodium hydroxide with the aqueous stream so that the sodium hydroxide combines with the ammonium ions and liberates free ammonia. Another aspect of the method includes mixing calcium hydroxide with the aqueous stream so that the calcium hydroxide combines with the phenol-formaldehyde resin to form calcium phenate. The liberated free ammonia is captured and scrubbed, while the solid calcium phenate is easily removed by filters. The aqueous process stream is then clean enough to be reused.

Abstract: A restraint package has a plurality of elongate bands comprising a base member and an overlying cover member interconnected to form an envelope for containing the restraint in a predetermined configuration. The cover has openable portions which when opened expose at least the ends of the bands facilitating the removal from the envelope.