Patents by Inventor John E. Cabaj

John E. Cabaj has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of Amides of Retinoic Acid Via Mixed Anhydride and Mixed Carbonate Intermediates
    Publication number: 20080221349
    Abstract: Processes for preparing amides of retinoic acid are disclosed. Intermediates useful in the preparation of amides of retinoic acid are also disclosed. In one version of the invention, fenretinide is produced via activation of retinoic acid (tretinoin) via its corresponding mixed anhydride or mixed carbonate followed by reaction of the activated intermediate with 4-aminophenol. Other amides of retinoic acid and isomers of retinoic acid, such as the 9-cis-form or 13-cis-form can also be made by this invention.
    Type: Application
    Filed: January 2, 2008
    Publication date: September 11, 2008
    Inventors: John E. Cabaj, Jeff J. Hutchison, James R. Zeller
  • Preparation of amides of retinoic acid via mixed anhydride and mixed carbonate intermediates
    Patent number: 7321064
    Abstract: Processes for preparing amides of retinoic acid are disclosed. Intermediates useful in the preparation of amides of retinoic acid are also disclosed. In one version of the invention, fenretinide is produced via activation of retinoic acid (tretinoin) via its corresponding mixed anhydride or mixed carbonate followed by reaction of the activated intermediate with 4-aminophenol. Other amides of retinoic acid and isomers of retinoic acid, such as the 9-cis-form or 13-cis-form can also be made by this invention.
    Type: Grant
    Filed: March 8, 2007
    Date of Patent: January 22, 2008
    Assignee: Cedarburg Pharmaceuticals, Inc.
    Inventors: John E. Cabaj, Jeff J. Hutchison
  • Process for the synthesis of oxandrolone
    Publication number: 20030032817
    Abstract: A process is disclosed for synthesizing oxandrolone 1 involving the bromination of compound 2 to obtain compound 3, followed by the highly selective de-bromination of compound 3 to obtain compound 4, followed by the oxidation of compound 4 to obtain compound 6, and finally the reduction of compound 6 to obtain oxandrolone 1.
    Type: Application
    Filed: May 15, 2002
    Publication date: February 13, 2003
    Inventors: John E. Cabaj, David L. Kairys, Paul M. Zizelman
  • Process to prepare tolterodine
    Patent number: 5922914
    Abstract: Disclosed is a novel intermediate, 3,4-dihydro-6-methyl-4-phenyl-2H-benzopyran-2-ol (IV) ##STR1## and an improved process for the preparation of tolterodine.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: July 13, 1999
    Assignee: Pharmacia & Upjohn Company
    Inventors: James R. Gage, John E. Cabaj