Abstract: The present disclosure provides compounds of Formula (Ia) and Formula (Ib) and the pharmaceutically acceptable salts and solvates thereof, wherein A1, A2, R1, R2, R3, and R4 are defined as set forth in the specification. The present disclosure also provides the use of compounds of Formula (Ia) or Formula (Ib) to treat a coronavirus infection in a subject.

Abstract: It was determined whether SNPs in SLC4A5 are associated with salt sensitivity of blood pressure (BP). Subjects consumed an isocaloric constant diet with a randomized order of 7 days low Na+ (10 mmol/d) and 7 days high Na+ (300 mmol/d) intake. Salt sensitivity was defined as a ?7 mm Hg increase in mean arterial pressure (MAP). 35 polymorphisms in 17 candidate genes were assayed. Association analyses with salt sensitivity revealed three variants that associated with salt sensitivity, two in SLC4A5 (rs7571842, rs10177833; P<0.001), and one in GRK4 (rs1801058; P=0.020). Paradoxical changes in blood pressure in response to changes in salt intake were also found associated with a SNP for DRD2 (rs6276). In conclusion, SLC4A5 variants are strongly associated with salt sensitivity of BP in Caucasian and a DRD2 SNP is a marker for paradoxical response to salt intake.

Abstract: A document processing system comprises an input receptacle for receiving documents. A transport mechanism receives the documents from the input receptacle and transports the documents past an image scanner and a discrimination unit. An output receptacle receives the documents from the transport mechanism after being transported past the image scanner and the discrimination unit. The image scanner obtains an image of the documents, obtains an image of a selected area of the documents, and obtains information contained in the selected area of the document. The discrimination unit determines the authenticity of the document. A system controller directs the flows of documents over the transport mechanism.

Abstract: A batch of bills is received, transported, and imaged to produce image data. The image data is reproducible as a visually readable image of at least a portion of each of the plurality of currency bills. Each currency bill includes a respective serial number. The serial numbers are extracted from the image data for each of the currency bills. Each extracted serial number is compared with a plurality of serial numbers in a currency bill database to determine if a currency bill associated with an extracted serial number is a suspect currency bill. One of the plurality of currency bills is determined to be a suspect currency bill based on the comparing. In response to determining the suspect currency bill, at least a portion of the produced image data is displayed as a visually readable image of the suspect currency bill on a display unit of the document processing system.

Abstract: It was determined whether SNPs in SLC4A5 are associated with salt sensitivity of blood pressure (BP). Subjects consumed an isocaloric constant diet with a randomized order of 7 days low Na+ (10 mmol/d) and 7 days high Na+ (300 mmol/d) intake. Salt sensitivity was defined as a ?7 mm Hg increase in mean arterial pressure (MAP). 35 polymorphisms in 17 candidate genes were assayed. Association analyses with salt sensitivity revealed three variants that associated with salt sensitivity, two in SLC4A5 (rs7571842, rs10177833; P<0.001), and one in GRK4 (rs1801058; P=0.020). Paradoxical changes in blood pressure in response to changes in salt intake were also found associated with a SNP for DRD2 (rs6276). In conclusion, SLC4A5 variants are strongly associated with salt sensitivity of BP in Caucasian and a DRD2 SNP is a marker for paradoxical response to salt intake.

Abstract: The present disclosure includes a method for quantifying contribution to overall variability of moisture content in wood products and associated computer software. The method comprises the steps of obtaining moisture content data for the wood products and identifying one or more sources of variability in the moisture content data. A contribution to overall variability from each of the one or more sources of variability is then quantified. One or more opportunities to impact the overall variability are then quantified, each of the one or more opportunities being associated with one or more executable steps.

Abstract: A batch of bills is received, transported, and imaged to produce image data. The image data is reproducible as a visually readable image of at least a portion of each of the plurality of currency bills. Each currency bill includes a respective serial number. The serial numbers are extracted from the image data for each of the currency bills. Each extracted serial number is compared with a plurality of serial numbers in a currency bill database to determine if a currency bill associated with an extracted serial number is a suspect currency bill. One of the plurality of currency bills is determined to be a suspect currency bill based on the comparing. In response to determining the suspect currency bill, at least a portion of the produced image data is displayed as a visually readable image of the suspect currency bill on a display unit of the document processing system.

Abstract: A system for tracking currency bills comprises a currency scanning device. The scanning device includes a sensor that retrieves currency identification characteristic information of each bill processed. The currency identification characteristic information permits the unique identification of each bill processed. The system further comprises a customer identification means and means for associating each processed bill with the customer depositing the bill. Means for identifying the customer (or customer account) associated with a particular processed bill after the deposit transaction has been completed is also included in the system.

Abstract: A method of processing a deposit transaction involving a plurality of physical documents includes receiving a data file associated with the deposit transaction. The data file includes a plurality of customer records. Each customer record includes image data. The method further includes transmitting a credit instruction to credit a customer financial account for an amount in response to the receiving the data file. The method further includes receiving physical documents associated with the deposit transaction. The method further includes generating a financial institution record for each one of the received physical documents and comparing the plurality of customer records with the generated financial institution records to determine if all physical documents associated with the deposit transaction were received during the act of receiving physical documents.

Abstract: The present disclosure includes a truss and a method for selecting components to construct a truss. The truss includes three or more chord elements (two or more upper chord elements and one or more lower chord elements) and one or more web elements. Embodiments of methods according to the disclosure include estimating a first change in length for each of the two or more upper chord elements and estimating a second change in length of each of the one or more lower chord elements, the first change in length and the second change in conditions to which the truss is exposed. The method may also include selecting the one or more web elements from the plurality of wood members such that it compensates for deformation caused by the first change in length and the second change in length.

Abstract: A document processing system includes an input receptacle for receiving documents. A transport mechanism receives the documents from the input receptacle and transports the documents past an image scanner and a discrimination unit. An output receptacle receives the documents from the transport mechanism after being transported past the full image scanner and the discrimination unit. The image scanner operates to obtain images of the documents and further operates to obtain images of selected portions of the documents, and further can obtain information contained in the selected portions. The discrimination unit operates to determine document authenticity. A system controller directs the flow of documents over the transport mechanism.

Abstract: Methods are provided for predicting warp of a lumber product at a given condition, such as relative humidity, temperature, moisture content, or the like. Note that this methodology may apply to any of crook, bow, twist, cup, or combinations of these quantities. The method involves measuring an original warp of a first wood product at a known condition; changing the condition of the first wood product to a new condition; measuring a second warp of the first wood product at the new condition; developing a prediction model based on data from the original warp and condition and the second warp; measuring an original warp and condition of the given wood product; and inputting data from the original warp and condition of the given wood product to the prediction model to determine warp at a given condition.

Abstract: The present disclosure generally relates to methods for predicting whether a wood product originated from a butt log. In some embodiments, such methods include dividing the wood product into at least two sections and obtaining, for each of the at least two sections, one or more optical measurements. One or more slope values may then be calculate, each representing an estimated rate at which the one or more optical measurements vary across the wood product. The slope values may then be used in a prediction model to determine a predictive output, the predictive output indicating whether the wood product originated from a butt log. Further aspects of the disclosure are directed towards a computer-readable storage medium for executing methods according to embodiments of the disclosure.

Abstract: A check and U.S. bank note processing device configured to process both checks and U.S. bank notes and a method of using the same. The device comprises an input receptacle configured to receive checks and U.S. bank notes and an output receptacle. The device further comprises a transport mechanism configured to transport the checks and U.S. bank notes from the input receptacle past an image scanner. The image scanner is configured to obtain an image of each check and U.S. bank note transported past the image scanner. The device is configured to determine the denominations of U.S. bank notes transported by the transport mechanism. The device further comprises a memory configured to store the images of checks transported past the image scanner.

Abstract: A check and U.S. bank note processing device configured to process both checks and U.S. bank notes. According to one embodiment, the device comprises an input receptacle configured to receive checks and U.S. bank notes and an output receptacle. The device further comprises a transport mechanism configured to transport the checks and U.S. bank notes from the input receptacle past an image scanner. The image scanner is configured to obtain an image of each check and U.S. bank note transported past the image scanner. The device is configured to determine the denominations of transported U.S. bank notes. The device is configured to capture information from checks transported past the image scanner. The device further comprises a memory configured to store the information captured from checks transported past the image scanner.

Abstract: A method for constructing a truss includes selecting three or more chord elements (two or more upper chord elements and one or more lower chord elements) and one or more web elements. The selecting of the components includes estimating a first change in length for each of the two or more upper chord elements and estimating a second change in length of each of the one or more lower chord elements, the first change in length and the second change in length in response to changes in conditions to which the truss is exposed. The one or more web elements are selected from the plurality of wood members to compensate for the deformation caused by the first change in length and the second change in length.

Abstract: A check and U.S. bank note processing device configured to process both checks and U.S. bank notes. The device comprises an input receptacle configured to receive checks and U.S. bank notes and an output receptacle. The device further comprises a transport mechanism configured to transport the checks and U.S. bank notes from the input receptacle past an image scanner. The image scanner is configured to obtain an image of each check and U.S. bank note transported past the image scanner. The device is configured to determine the serial numbers of U.S. bank notes transported past the image scanner. The device further comprises a memory configured to store the determined serial numbers of U.S. bank notes.

Abstract: A document processing system includes a communications port and a controller. The communications port is configured to communicatively couple the document processing system to a network and to receive a data file associated with a deposit amount. The data file includes customer deposit information associated with documents. The controller is configured to determine if any of the first plurality of documents are suspect documents based on a comparison of the customer deposit information with suspect information. The controller is configured to generate a credit instruction for an amount equal to a percentage of the deposit amount minus an amount associated with ones of the documents determined to be suspect documents. In response to the controller determining that one of the first plurality of documents is a suspect document, the controller is configured to transmit a notice over the network. The notice includes image data associated with the determined suspect document.

Abstract: A batch of bills is received, transported, and imaged to produce image data. The image data is reproducible as a visually readable image of at least a portion of each of the plurality of currency bills. Each currency bill includes a respective serial number. The serial numbers are extracted from the image data for each of the currency bills. Each extracted serial number is compared with a plurality of serial numbers in a currency bill database to determine if a currency bill associated with an extracted serial number is a suspect currency bill. One of the plurality of currency bills is determined to be a suspect currency bill based on the comparing. In response to determining the suspect currency bill, at least a portion of the produced image data is displayed as a visually readable image of the suspect currency bill on a display unit of the document processing system.

Abstract: A vertically arranged combination desktop currency denominating machine and currency dispenser comprising a currency denominating module adapted to receive a stack of currency bills to be denominated and to denominate the received currency bills, wherein a transport mechanism transports bills individually from an input receptacle adapted to receive the stack of currency bills to one or more output receptacles. The combination further comprising a dispenser retaining section adapted to store currency bills to be dispensed to the one or more output receptacles during a dispensing operation, the retaining section comprising one or more dispensing receptacles, each dispensing receptacle adapted to hold bills having a common denomination, wherein the dispenser retainer section is positioned above the currency denominating module.